Summary | |
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Symbol | CD34 |
Name | CD34 molecule |
Aliases | CD34 antigen; CD antigen CD34; Hematopoietic progenitor cell antigen CD34 |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF06365 CD34/Podocalyxin family |
Function |
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. |
Biological Process |
GO:0001525 angiogenesis GO:0001570 vasculogenesis GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001666 response to hypoxia GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0001822 kidney development GO:0001894 tissue homeostasis GO:0001935 endothelial cell proliferation GO:0003013 circulatory system process GO:0003014 renal system process GO:0003094 glomerular filtration GO:0003158 endothelium development GO:0006809 nitric oxide biosynthetic process GO:0007160 cell-matrix adhesion GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008015 blood circulation GO:0008217 regulation of blood pressure GO:0009266 response to temperature stimulus GO:0009306 protein secretion GO:0009408 response to heat GO:0016050 vesicle organization GO:0030193 regulation of blood coagulation GO:0030195 negative regulation of blood coagulation GO:0031589 cell-substrate adhesion GO:0032102 negative regulation of response to external stimulus GO:0032613 interleukin-10 production GO:0032623 interleukin-2 production GO:0032640 tumor necrosis factor production GO:0032653 regulation of interleukin-10 production GO:0032663 regulation of interleukin-2 production GO:0032680 regulation of tumor necrosis factor production GO:0032703 negative regulation of interleukin-2 production GO:0032720 negative regulation of tumor necrosis factor production GO:0032733 positive regulation of interleukin-10 production GO:0032835 glomerulus development GO:0034605 cellular response to heat GO:0035759 mesangial cell-matrix adhesion GO:0035850 epithelial cell differentiation involved in kidney development GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0036301 macrophage colony-stimulating factor production GO:0038001 paracrine signaling GO:0042476 odontogenesis GO:0042481 regulation of odontogenesis GO:0042482 positive regulation of odontogenesis GO:0044467 glial cell-derived neurotrophic factor secretion GO:0045019 negative regulation of nitric oxide biosynthetic process GO:0045428 regulation of nitric oxide biosynthetic process GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0046209 nitric oxide metabolic process GO:0048514 blood vessel morphogenesis GO:0048871 multicellular organismal homeostasis GO:0050663 cytokine secretion GO:0050673 epithelial cell proliferation GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050709 negative regulation of protein secretion GO:0050710 negative regulation of cytokine secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050817 coagulation GO:0050818 regulation of coagulation GO:0050819 negative regulation of coagulation GO:0050878 regulation of body fluid levels GO:0050900 leukocyte migration GO:0051047 positive regulation of secretion GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051222 positive regulation of protein transport GO:0051224 negative regulation of protein transport GO:0060055 angiogenesis involved in wound healing GO:0060249 anatomical structure homeostasis GO:0060290 transdifferentiation GO:0061005 cell differentiation involved in kidney development GO:0061041 regulation of wound healing GO:0061042 vascular wound healing GO:0061045 negative regulation of wound healing GO:0061437 renal system vasculature development GO:0061440 kidney vasculature development GO:0061448 connective tissue development GO:0070482 response to oxygen levels GO:0070970 interleukin-2 secretion GO:0070997 neuron death GO:0071425 hematopoietic stem cell proliferation GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071604 transforming growth factor beta production GO:0071611 granulocyte colony-stimulating factor production GO:0071634 regulation of transforming growth factor beta production GO:0071636 positive regulation of transforming growth factor beta production GO:0071655 regulation of granulocyte colony-stimulating factor production GO:0071657 positive regulation of granulocyte colony-stimulating factor production GO:0071706 tumor necrosis factor superfamily cytokine production GO:0071971 extracellular exosome assembly GO:0072001 renal system development GO:0072006 nephron development GO:0072007 mesangial cell differentiation GO:0072008 glomerular mesangial cell differentiation GO:0072009 nephron epithelium development GO:0072010 glomerular epithelium development GO:0072011 glomerular endothelium development GO:0072012 glomerulus vasculature development GO:0072073 kidney epithelium development GO:0072089 stem cell proliferation GO:0072109 glomerular mesangium development GO:0072202 cell differentiation involved in metanephros development GO:0072209 metanephric mesangial cell differentiation GO:0072210 metanephric nephron development GO:0072223 metanephric glomerular mesangium development GO:0072224 metanephric glomerulus development GO:0072239 metanephric glomerulus vasculature development GO:0072254 metanephric glomerular mesangial cell differentiation GO:0072593 reactive oxygen species metabolic process GO:0097205 renal filtration GO:1900034 regulation of cellular response to heat GO:1900035 negative regulation of cellular response to heat GO:1900037 regulation of cellular response to hypoxia GO:1900038 negative regulation of cellular response to hypoxia GO:1900040 regulation of interleukin-2 secretion GO:1900041 negative regulation of interleukin-2 secretion GO:1900046 regulation of hemostasis GO:1900047 negative regulation of hemostasis GO:1900166 regulation of glial cell-derived neurotrophic factor secretion GO:1900168 positive regulation of glial cell-derived neurotrophic factor secretion GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901256 regulation of macrophage colony-stimulating factor production GO:1901258 positive regulation of macrophage colony-stimulating factor production GO:1901342 regulation of vasculature development GO:1903034 regulation of response to wounding GO:1903035 negative regulation of response to wounding GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903427 negative regulation of reactive oxygen species biosynthetic process GO:1903531 negative regulation of secretion by cell GO:1903532 positive regulation of secretion by cell GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production GO:1904018 positive regulation of vasculature development GO:1904238 pericyte cell differentiation GO:1904406 negative regulation of nitric oxide metabolic process GO:1904950 negative regulation of establishment of protein localization GO:1904951 positive regulation of establishment of protein localization GO:2000027 regulation of organ morphogenesis GO:2000377 regulation of reactive oxygen species metabolic process GO:2000378 negative regulation of reactive oxygen species metabolic process GO:2001057 reactive nitrogen species metabolic process GO:2001212 regulation of vasculogenesis GO:2001214 positive regulation of vasculogenesis |
Molecular Function |
GO:0008134 transcription factor binding GO:0030246 carbohydrate binding GO:0043168 anion binding GO:0043199 sulfate binding GO:1901681 sulfur compound binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0009925 basal plasma membrane GO:0016323 basolateral plasma membrane GO:0016324 apical plasma membrane GO:0036053 glomerular endothelium fenestra GO:0045171 intercellular bridge GO:0045177 apical part of cell GO:0045178 basal part of cell GO:0046930 pore complex GO:0098552 side of membrane |
KEGG |
hsa04514 Cell adhesion molecules (CAMs) hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Summary | |
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Symbol | CD34 |
Name | CD34 molecule |
Aliases | CD34 antigen; CD antigen CD34; Hematopoietic progenitor cell antigen CD34 |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD34 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CD34 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CD34 |
Name | CD34 molecule |
Aliases | CD34 antigen; CD antigen CD34; Hematopoietic progenitor cell antigen CD34 |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD34 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CD34 |
Name | CD34 molecule |
Aliases | CD34 antigen; CD antigen CD34; Hematopoietic progenitor cell antigen CD34 |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD34 in various data sets.
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Points in the above scatter plot represent the mutation difference of CD34 in various data sets.
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Summary | |
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Symbol | CD34 |
Name | CD34 molecule |
Aliases | CD34 antigen; CD antigen CD34; Hematopoietic progenitor cell antigen CD34 |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD34. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CD34 |
Name | CD34 molecule |
Aliases | CD34 antigen; CD antigen CD34; Hematopoietic progenitor cell antigen CD34 |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD34. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD34. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CD34 |
Name | CD34 molecule |
Aliases | CD34 antigen; CD antigen CD34; Hematopoietic progenitor cell antigen CD34 |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD34. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CD34 |
Name | CD34 molecule |
Aliases | CD34 antigen; CD antigen CD34; Hematopoietic progenitor cell antigen CD34 |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD34 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CD34 |
Name | CD34 molecule |
Aliases | CD34 antigen; CD antigen CD34; Hematopoietic progenitor cell antigen CD34 |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD34 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |