Browse CD36

Summary
SymbolCD36
NameCD36 molecule (thrombospondin receptor)
Aliases SCARB3; GP4; GP3B; CD36 antigen (collagen type I receptor, thrombospondin receptor); BDPLT10; CHDS7; PASIV; ......
Chromosomal Location7q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein Membrane raft Golgi apparatus Apical cell membrane Note=Upon ligand-binding, internalized through dynamin-dependent endocytosis.
Domain PF01130 CD36 family
Function

Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211). ; FUNCTION: (Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.

> Gene Ontology
 
Biological Process GO:0000302 response to reactive oxygen species
GO:0000303 response to superoxide
GO:0000305 response to oxygen radical
GO:0001101 response to acid chemical
GO:0001819 positive regulation of cytokine production
GO:0001952 regulation of cell-matrix adhesion
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002218 activation of innate immune response
GO:0002221 pattern recognition receptor signaling pathway
GO:0002224 toll-like receptor signaling pathway
GO:0002237 response to molecule of bacterial origin
GO:0002367 cytokine production involved in immune response
GO:0002440 production of molecular mediator of immune response
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002478 antigen processing and presentation of exogenous peptide antigen
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002576 platelet degranulation
GO:0002697 regulation of immune effector process
GO:0002699 positive regulation of immune effector process
GO:0002700 regulation of production of molecular mediator of immune response
GO:0002702 positive regulation of production of molecular mediator of immune response
GO:0002718 regulation of cytokine production involved in immune response
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002757 immune response-activating signal transduction
GO:0002758 innate immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0006606 protein import into nucleus
GO:0006801 superoxide metabolic process
GO:0006869 lipid transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006887 exocytosis
GO:0006898 receptor-mediated endocytosis
GO:0006909 phagocytosis
GO:0006910 phagocytosis, recognition
GO:0006911 phagocytosis, engulfment
GO:0006913 nucleocytoplasmic transport
GO:0006979 response to oxidative stress
GO:0007160 cell-matrix adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007263 nitric oxide mediated signal transduction
GO:0007586 digestion
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008037 cell recognition
GO:0009306 protein secretion
GO:0009636 response to toxic substance
GO:0010035 response to inorganic substance
GO:0010324 membrane invagination
GO:0010742 macrophage derived foam cell differentiation
GO:0010743 regulation of macrophage derived foam cell differentiation
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010810 regulation of cell-substrate adhesion
GO:0010811 positive regulation of cell-substrate adhesion
GO:0010876 lipid localization
GO:0010878 cholesterol storage
GO:0010883 regulation of lipid storage
GO:0010884 positive regulation of lipid storage
GO:0010885 regulation of cholesterol storage
GO:0010886 positive regulation of cholesterol storage
GO:0010934 macrophage cytokine production
GO:0010935 regulation of macrophage cytokine production
GO:0015849 organic acid transport
GO:0015850 organic hydroxy compound transport
GO:0015918 sterol transport
GO:0017038 protein import
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0019430 removal of superoxide radicals
GO:0019882 antigen processing and presentation
GO:0019884 antigen processing and presentation of exogenous antigen
GO:0019915 lipid storage
GO:0019932 second-messenger-mediated signaling
GO:0019934 cGMP-mediated signaling
GO:0019935 cyclic-nucleotide-mediated signaling
GO:0022600 digestive system process
GO:0030100 regulation of endocytosis
GO:0030193 regulation of blood coagulation
GO:0030194 positive regulation of blood coagulation
GO:0030198 extracellular matrix organization
GO:0030299 intestinal cholesterol absorption
GO:0030301 cholesterol transport
GO:0031334 positive regulation of protein complex assembly
GO:0031349 positive regulation of defense response
GO:0031589 cell-substrate adhesion
GO:0031623 receptor internalization
GO:0032386 regulation of intracellular transport
GO:0032387 negative regulation of intracellular transport
GO:0032493 response to bacterial lipoprotein
GO:0032496 response to lipopolysaccharide
GO:0032611 interleukin-1 beta production
GO:0032612 interleukin-1 production
GO:0032615 interleukin-12 production
GO:0032635 interleukin-6 production
GO:0032640 tumor necrosis factor production
GO:0032655 regulation of interleukin-12 production
GO:0032675 regulation of interleukin-6 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032844 regulation of homeostatic process
GO:0033157 regulation of intracellular protein transport
GO:0033194 response to hydroperoxide
GO:0034196 acylglycerol transport
GO:0034197 triglyceride transport
GO:0034381 plasma lipoprotein particle clearance
GO:0034383 low-density lipoprotein particle clearance
GO:0034504 protein localization to nucleus
GO:0034599 cellular response to oxidative stress
GO:0034614 cellular response to reactive oxygen species
GO:0035376 sterol import
GO:0035634 response to stilbenoid
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042306 regulation of protein import into nucleus
GO:0042308 negative regulation of protein import into nucleus
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042742 defense response to bacterium
GO:0042953 lipoprotein transport
GO:0042990 regulation of transcription factor import into nucleus
GO:0042991 transcription factor import into nucleus
GO:0042992 negative regulation of transcription factor import into nucleus
GO:0043062 extracellular structure organization
GO:0043112 receptor metabolic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254 regulation of protein complex assembly
GO:0043277 apoptotic cell clearance
GO:0043410 positive regulation of MAPK cascade
GO:0043900 regulation of multi-organism process
GO:0043901 negative regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0044089 positive regulation of cellular component biogenesis
GO:0044110 growth involved in symbiotic interaction
GO:0044116 growth of symbiont involved in interaction with host
GO:0044117 growth of symbiont in host
GO:0044126 regulation of growth of symbiont in host
GO:0044130 negative regulation of growth of symbiont in host
GO:0044144 modulation of growth of symbiont involved in interaction with host
GO:0044146 negative regulation of growth of symbiont involved in interaction with host
GO:0044241 lipid digestion
GO:0044539 long-chain fatty acid import
GO:0044546 NLRP3 inflammasome complex assembly
GO:0044744 protein targeting to nucleus
GO:0044872 lipoprotein localization
GO:0045055 regulated exocytosis
GO:0045088 regulation of innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045785 positive regulation of cell adhesion
GO:0045807 positive regulation of endocytosis
GO:0045926 negative regulation of growth
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046823 negative regulation of nucleocytoplasmic transport
GO:0048002 antigen processing and presentation of peptide antigen
GO:0048871 multicellular organismal homeostasis
GO:0050663 cytokine secretion
GO:0050701 interleukin-1 secretion
GO:0050702 interleukin-1 beta secretion
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050764 regulation of phagocytosis
GO:0050766 positive regulation of phagocytosis
GO:0050817 coagulation
GO:0050818 regulation of coagulation
GO:0050820 positive regulation of coagulation
GO:0050830 defense response to Gram-positive bacterium
GO:0050878 regulation of body fluid levels
GO:0050892 intestinal absorption
GO:0050909 sensory perception of taste
GO:0051051 negative regulation of transport
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051224 negative regulation of protein transport
GO:0051235 maintenance of location
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0055074 calcium ion homeostasis
GO:0055094 response to lipoprotein particle
GO:0055095 lipoprotein particle mediated signaling
GO:0055096 low-density lipoprotein particle mediated signaling
GO:0055098 response to low-density lipoprotein particle
GO:0060099 regulation of phagocytosis, engulfment
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0060627 regulation of vesicle-mediated transport
GO:0060907 positive regulation of macrophage cytokine production
GO:0061041 regulation of wound healing
GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response
GO:0061082 myeloid leukocyte cytokine production
GO:0070339 response to bacterial lipopeptide
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070391 response to lipoteichoic acid
GO:0070508 cholesterol import
GO:0070542 response to fatty acid
GO:0070543 response to linoleic acid
GO:0071216 cellular response to biotic stimulus
GO:0071219 cellular response to molecule of bacterial origin
GO:0071220 cellular response to bacterial lipoprotein
GO:0071221 cellular response to bacterial lipopeptide
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
GO:0071396 cellular response to lipid
GO:0071402 cellular response to lipoprotein particle stimulus
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0071447 cellular response to hydroperoxide
GO:0071450 cellular response to oxygen radical
GO:0071451 cellular response to superoxide
GO:0071706 tumor necrosis factor superfamily cytokine production
GO:0071724 response to diacyl bacterial lipopeptide
GO:0071726 cellular response to diacyl bacterial lipopeptide
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072564 blood microparticle formation
GO:0072593 reactive oxygen species metabolic process
GO:0090077 foam cell differentiation
GO:0090303 positive regulation of wound healing
GO:0090317 negative regulation of intracellular protein transport
GO:0090322 regulation of superoxide metabolic process
GO:0097006 regulation of plasma lipoprotein particle levels
GO:0097009 energy homeostasis
GO:0097435 fibril organization
GO:0098542 defense response to other organism
GO:0098754 detoxification
GO:0098856 intestinal lipid absorption
GO:0098869 cellular oxidant detoxification
GO:0099024 plasma membrane invagination
GO:1900046 regulation of hemostasis
GO:1900048 positive regulation of hemostasis
GO:1900180 regulation of protein localization to nucleus
GO:1900181 negative regulation of protein localization to nucleus
GO:1900225 regulation of NLRP3 inflammasome complex assembly
GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
GO:1900407 regulation of cellular response to oxidative stress
GO:1901031 regulation of response to reactive oxygen species
GO:1902593 single-organism nuclear import
GO:1902882 regulation of response to oxidative stress
GO:1903034 regulation of response to wounding
GO:1903036 positive regulation of response to wounding
GO:1903533 regulation of protein targeting
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production
GO:1903828 negative regulation of cellular protein localization
GO:1904589 regulation of protein import
GO:1904590 negative regulation of protein import
GO:1904950 negative regulation of establishment of protein localization
GO:1905153 regulation of membrane invagination
GO:1905155 positive regulation of membrane invagination
GO:1990000 amyloid fibril formation
GO:1990748 cellular detoxification
GO:2000121 regulation of removal of superoxide radicals
GO:2000332 regulation of blood microparticle formation
GO:2000334 positive regulation of blood microparticle formation
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000505 regulation of energy homeostasis
Molecular Function GO:0005041 low-density lipoprotein receptor activity
GO:0008035 high-density lipoprotein particle binding
GO:0008329 signaling pattern recognition receptor activity
GO:0019838 growth factor binding
GO:0019955 cytokine binding
GO:0030169 low-density lipoprotein particle binding
GO:0030228 lipoprotein particle receptor activity
GO:0038024 cargo receptor activity
GO:0038187 pattern recognition receptor activity
GO:0050431 transforming growth factor beta binding
GO:0070053 thrombospondin receptor activity
GO:0070892 lipoteichoic acid receptor activity
GO:0071813 lipoprotein particle binding
GO:0071814 protein-lipid complex binding
Cellular Component GO:0005903 brush border
GO:0009897 external side of plasma membrane
GO:0016324 apical plasma membrane
GO:0030139 endocytic vesicle
GO:0030141 secretory granule
GO:0030659 cytoplasmic vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030667 secretory granule membrane
GO:0031091 platelet alpha granule
GO:0031092 platelet alpha granule membrane
GO:0031253 cell projection membrane
GO:0031526 brush border membrane
GO:0045121 membrane raft
GO:0045177 apical part of cell
GO:0045335 phagocytic vesicle
GO:0098552 side of membrane
GO:0098589 membrane region
GO:0098857 membrane microdomain
GO:0098862 cluster of actin-based cell projections
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa03320 PPAR signaling pathway
hsa04145 Phagosome
hsa04152 AMPK signaling pathway
hsa04512 ECM-receptor interaction
hsa04640 Hematopoietic cell lineage
hsa04920 Adipocytokine signaling pathway
hsa04975 Fat digestion and absorption
Reactome R-HSA-166054: Activated TLR4 signalling
R-HSA-1280218: Adaptive Immune System
R-HSA-1236975: Antigen processing-Cross presentation
R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-983169: Class I MHC mediated antigen processing & presentation
R-HSA-1236973: Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5602358: Diseases associated with the TLR signaling cascade
R-HSA-5260271: Diseases of Immune System
R-HSA-1236974: ER-Phagosome pathway
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-109582: Hemostasis
R-HSA-5603041: IRAK4 deficiency (TLR2/4)
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-6785807: Interleukin-4 and 13 signaling
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-5602498: MyD88 deficiency (TLR2/4)
R-HSA-166058: MyD88
R-HSA-6798695: Neutrophil degranulation
R-HSA-1989781: PPARA activates gene expression
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-114608: Platelet degranulation
R-HSA-5686938: Regulation of TLR by endogenous ligand
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-76005: Response to elevated platelet cytosolic Ca2+
R-HSA-3000471: Scavenging by Class B Receptors
R-HSA-449147: Signaling by Interleukins
R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade
R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179: Toll Like Receptor TLR1
R-HSA-168188: Toll Like Receptor TLR6
R-HSA-168898: Toll-Like Receptors Cascades
R-HSA-381340: Transcriptional regulation of white adipocyte differentiation
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolCD36
NameCD36 molecule (thrombospondin receptor)
Aliases SCARB3; GP4; GP3B; CD36 antigen (collagen type I receptor, thrombospondin receptor); BDPLT10; CHDS7; PASIV; ......
Chromosomal Location7q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CD36 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCD36
NameCD36 molecule (thrombospondin receptor)
Aliases SCARB3; GP4; GP3B; CD36 antigen (collagen type I receptor, thrombospondin receptor); BDPLT10; CHDS7; PASIV; ......
Chromosomal Location7q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CD36 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.18; FDR: 0.04630 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCD36
NameCD36 molecule (thrombospondin receptor)
Aliases SCARB3; GP4; GP3B; CD36 antigen (collagen type I receptor, thrombospondin receptor); BDPLT10; CHDS7; PASIV; ......
Chromosomal Location7q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CD36 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6740.256
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.6650.373
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0610.962
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.510.00741
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-2.2240.155
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.6050.763
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0050.993
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.070.97
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0040.998
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.9180.628
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.3290.397
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1060.666
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CD36 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.311.82.51
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.516.7-4.21
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCD36
NameCD36 molecule (thrombospondin receptor)
Aliases SCARB3; GP4; GP3B; CD36 antigen (collagen type I receptor, thrombospondin receptor); BDPLT10; CHDS7; PASIV; ......
Chromosomal Location7q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD36. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCD36
NameCD36 molecule (thrombospondin receptor)
Aliases SCARB3; GP4; GP3B; CD36 antigen (collagen type I receptor, thrombospondin receptor); BDPLT10; CHDS7; PASIV; ......
Chromosomal Location7q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD36. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD36.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCD36
NameCD36 molecule (thrombospondin receptor)
Aliases SCARB3; GP4; GP3B; CD36 antigen (collagen type I receptor, thrombospondin receptor); BDPLT10; CHDS7; PASIV; ......
Chromosomal Location7q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD36. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCD36
NameCD36 molecule (thrombospondin receptor)
Aliases SCARB3; GP4; GP3B; CD36 antigen (collagen type I receptor, thrombospondin receptor); BDPLT10; CHDS7; PASIV; ......
Chromosomal Location7q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CD36 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCD36
NameCD36 molecule (thrombospondin receptor)
Aliases SCARB3; GP4; GP3B; CD36 antigen (collagen type I receptor, thrombospondin receptor); BDPLT10; CHDS7; PASIV; ......
Chromosomal Location7q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CD36 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCD36
NameCD36 molecule (thrombospondin receptor)
Aliases SCARB3; GP4; GP3B; CD36 antigen (collagen type I receptor, thrombospondin receptor); BDPLT10; CHDS7; PASIV; ......
Chromosomal Location7q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CD36 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.