Summary | |
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Symbol | CD38 |
Name | CD38 molecule |
Aliases | ADP-ribosyl cyclase 1; CD38 antigen (p45); ADPRC 1; ADPRC1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cycli ...... |
Chromosomal Location | 4p15.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type II membrane protein. |
Domain |
PF02267 ADP-ribosyl cyclase |
Function |
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. |
Biological Process |
GO:0001101 response to acid chemical GO:0001558 regulation of cell growth GO:0001666 response to hypoxia GO:0001894 tissue homeostasis GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002793 positive regulation of peptide secretion GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006979 response to oxidative stress GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007565 female pregnancy GO:0008015 blood circulation GO:0009306 protein secretion GO:0009914 hormone transport GO:0010817 regulation of hormone levels GO:0015833 peptide transport GO:0016049 cell growth GO:0019229 regulation of vasoconstriction GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030307 positive regulation of cell growth GO:0030888 regulation of B cell proliferation GO:0030890 positive regulation of B cell proliferation GO:0032024 positive regulation of insulin secretion GO:0032355 response to estradiol GO:0032526 response to retinoic acid GO:0032570 response to progesterone GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033194 response to hydroperoxide GO:0034103 regulation of tissue remodeling GO:0034104 negative regulation of tissue remodeling GO:0035150 regulation of tube size GO:0036293 response to decreased oxygen levels GO:0042100 B cell proliferation GO:0042113 B cell activation GO:0042310 vasoconstriction GO:0042493 response to drug GO:0042886 amide transport GO:0044057 regulation of system process GO:0044706 multi-multicellular organism process GO:0045124 regulation of bone resorption GO:0045453 bone resorption GO:0045779 negative regulation of bone resorption GO:0045907 positive regulation of vasoconstriction GO:0045927 positive regulation of growth GO:0046651 lymphocyte proliferation GO:0046849 bone remodeling GO:0046850 regulation of bone remodeling GO:0046851 negative regulation of bone remodeling GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046887 positive regulation of hormone secretion GO:0048167 regulation of synaptic plasticity GO:0048545 response to steroid hormone GO:0048771 tissue remodeling GO:0048871 multicellular organismal homeostasis GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050796 regulation of insulin secretion GO:0050804 modulation of synaptic transmission GO:0050805 negative regulation of synaptic transmission GO:0050851 antigen receptor-mediated signaling pathway GO:0050853 B cell receptor signaling pathway GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050871 positive regulation of B cell activation GO:0050880 regulation of blood vessel size GO:0051047 positive regulation of secretion GO:0051222 positive regulation of protein transport GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051480 regulation of cytosolic calcium ion concentration GO:0055074 calcium ion homeostasis GO:0060249 anatomical structure homeostasis GO:0060292 long term synaptic depression GO:0070482 response to oxygen levels GO:0070555 response to interleukin-1 GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0090066 regulation of anatomical structure size GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0090277 positive regulation of peptide hormone secretion GO:1901654 response to ketone GO:1903522 regulation of blood circulation GO:1903524 positive regulation of blood circulation GO:1903532 positive regulation of secretion by cell GO:1904951 positive regulation of establishment of protein localization |
Molecular Function |
GO:0003953 NAD+ nucleosidase activity GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GO:0016829 lyase activity GO:0016849 phosphorus-oxygen lyase activity GO:0050135 NAD(P)+ nucleosidase activity |
Cellular Component | - |
KEGG |
hsa04020 Calcium signaling pathway hsa04640 Hematopoietic cell lineage hsa04921 Oxytocin signaling pathway hsa04970 Salivary secretion hsa04972 Pancreatic secretion hsa00760 Nicotinate and nicotinamide metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-1430728: Metabolism R-HSA-196854: Metabolism of vitamins and cofactors R-HSA-196849: Metabolism of water-soluble vitamins and cofactors R-HSA-196807: Nicotinate metabolism |
Summary | |
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Symbol | CD38 |
Name | CD38 molecule |
Aliases | ADP-ribosyl cyclase 1; CD38 antigen (p45); ADPRC 1; ADPRC1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cycli ...... |
Chromosomal Location | 4p15.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD38 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CD38 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CD38 |
Name | CD38 molecule |
Aliases | ADP-ribosyl cyclase 1; CD38 antigen (p45); ADPRC 1; ADPRC1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cycli ...... |
Chromosomal Location | 4p15.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD38 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CD38 |
Name | CD38 molecule |
Aliases | ADP-ribosyl cyclase 1; CD38 antigen (p45); ADPRC 1; ADPRC1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cycli ...... |
Chromosomal Location | 4p15.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD38 in various data sets.
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Points in the above scatter plot represent the mutation difference of CD38 in various data sets.
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Summary | |
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Symbol | CD38 |
Name | CD38 molecule |
Aliases | ADP-ribosyl cyclase 1; CD38 antigen (p45); ADPRC 1; ADPRC1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cycli ...... |
Chromosomal Location | 4p15.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD38. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CD38 |
Name | CD38 molecule |
Aliases | ADP-ribosyl cyclase 1; CD38 antigen (p45); ADPRC 1; ADPRC1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cycli ...... |
Chromosomal Location | 4p15.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD38. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD38. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CD38 |
Name | CD38 molecule |
Aliases | ADP-ribosyl cyclase 1; CD38 antigen (p45); ADPRC 1; ADPRC1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cycli ...... |
Chromosomal Location | 4p15.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD38. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CD38 |
Name | CD38 molecule |
Aliases | ADP-ribosyl cyclase 1; CD38 antigen (p45); ADPRC 1; ADPRC1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cycli ...... |
Chromosomal Location | 4p15.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD38 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CD38 |
Name | CD38 molecule |
Aliases | ADP-ribosyl cyclase 1; CD38 antigen (p45); ADPRC 1; ADPRC1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cycli ...... |
Chromosomal Location | 4p15.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD38 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CD38 |
Name | CD38 molecule |
Aliases | ADP-ribosyl cyclase 1; CD38 antigen (p45); ADPRC 1; ADPRC1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cycli ...... |
Chromosomal Location | 4p15.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD38 collected from DrugBank database. |
Details on drugs targeting CD38.
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