Summary | |
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Symbol | CD40 |
Name | CD40 molecule, TNF receptor superfamily member 5 |
Aliases | Bp50; TNFRSF5; tumor necrosis factor receptor superfamily, member 5; CDW40; B cell surface antigen CD40; B c ...... |
Chromosomal Location | 20q12-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform I: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform II: Secreted. |
Domain |
PF00020 TNFR/NGFR cysteine-rich region |
Function |
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. |
Biological Process |
GO:0000018 regulation of DNA recombination GO:0001562 response to protozoan GO:0001819 positive regulation of cytokine production GO:0002200 somatic diversification of immune receptors GO:0002204 somatic recombination of immunoglobulin genes involved in immune response GO:0002208 somatic diversification of immunoglobulins involved in immune response GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002312 B cell activation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002377 immunoglobulin production GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus GO:0002637 regulation of immunoglobulin production GO:0002639 positive regulation of immunoglobulin production GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002712 regulation of B cell mediated immunity GO:0002714 positive regulation of B cell mediated immunity GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002889 regulation of immunoglobulin mediated immune response GO:0002891 positive regulation of immunoglobulin mediated immune response GO:0006310 DNA recombination GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0007596 blood coagulation GO:0007599 hemostasis GO:0009306 protein secretion GO:0009612 response to mechanical stimulus GO:0009615 response to virus GO:0016064 immunoglobulin mediated immune response GO:0016444 somatic cell DNA recombination GO:0016445 somatic diversification of immunoglobulins GO:0016447 somatic recombination of immunoglobulin gene segments GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019724 B cell mediated immunity GO:0030168 platelet activation GO:0030888 regulation of B cell proliferation GO:0030890 positive regulation of B cell proliferation GO:0032496 response to lipopolysaccharide GO:0032615 interleukin-12 production GO:0032655 regulation of interleukin-12 production GO:0032735 positive regulation of interleukin-12 production GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0033674 positive regulation of kinase activity GO:0034612 response to tumor necrosis factor GO:0042100 B cell proliferation GO:0042113 B cell activation GO:0042508 tyrosine phosphorylation of Stat1 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042510 regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042832 defense response to protozoan GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043491 protein kinase B signaling GO:0045190 isotype switching GO:0045191 regulation of isotype switching GO:0045830 positive regulation of isotype switching GO:0045860 positive regulation of protein kinase activity GO:0045911 positive regulation of DNA recombination GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046651 lymphocyte proliferation GO:0048291 isotype switching to IgG isotypes GO:0048302 regulation of isotype switching to IgG isotypes GO:0048304 positive regulation of isotype switching to IgG isotypes GO:0048305 immunoglobulin secretion GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050708 regulation of protein secretion GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050817 coagulation GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050871 positive regulation of B cell activation GO:0050878 regulation of body fluid levels GO:0051023 regulation of immunoglobulin secretion GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051607 defense response to virus GO:0055074 calcium ion homeostasis GO:0070528 protein kinase C signaling GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071214 cellular response to abiotic stimulus GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071260 cellular response to mechanical stimulus GO:0071356 cellular response to tumor necrosis factor GO:0071396 cellular response to lipid GO:0071496 cellular response to external stimulus GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072577 endothelial cell apoptotic process GO:0090036 regulation of protein kinase C signaling GO:0090037 positive regulation of protein kinase C signaling GO:0097696 STAT cascade GO:0098542 defense response to other organism GO:1904019 epithelial cell apoptotic process GO:1904035 regulation of epithelial cell apoptotic process GO:1904037 positive regulation of epithelial cell apoptotic process GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:2000351 regulation of endothelial cell apoptotic process GO:2000353 positive regulation of endothelial cell apoptotic process |
Molecular Function |
GO:0003823 antigen binding GO:0005031 tumor necrosis factor-activated receptor activity GO:0005035 death receptor activity GO:0031625 ubiquitin protein ligase binding GO:0044389 ubiquitin-like protein ligase binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0035631 CD40 receptor complex GO:0043235 receptor complex GO:0098552 side of membrane GO:0098802 plasma membrane receptor complex |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04064 NF-kappa B signaling pathway hsa04514 Cell adhesion molecules (CAMs) hsa04620 Toll-like receptor signaling pathway hsa04672 Intestinal immune network for IgA production |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-5676594: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5668541: TNFR2 non-canonical NF-kB pathway |
Summary | |
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Symbol | CD40 |
Name | CD40 molecule, TNF receptor superfamily member 5 |
Aliases | Bp50; TNFRSF5; tumor necrosis factor receptor superfamily, member 5; CDW40; B cell surface antigen CD40; B c ...... |
Chromosomal Location | 20q12-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD40 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CD40 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CD40 |
Name | CD40 molecule, TNF receptor superfamily member 5 |
Aliases | Bp50; TNFRSF5; tumor necrosis factor receptor superfamily, member 5; CDW40; B cell surface antigen CD40; B c ...... |
Chromosomal Location | 20q12-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD40 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CD40 |
Name | CD40 molecule, TNF receptor superfamily member 5 |
Aliases | Bp50; TNFRSF5; tumor necrosis factor receptor superfamily, member 5; CDW40; B cell surface antigen CD40; B c ...... |
Chromosomal Location | 20q12-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD40 in various data sets.
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Points in the above scatter plot represent the mutation difference of CD40 in various data sets.
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Summary | |
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Symbol | CD40 |
Name | CD40 molecule, TNF receptor superfamily member 5 |
Aliases | Bp50; TNFRSF5; tumor necrosis factor receptor superfamily, member 5; CDW40; B cell surface antigen CD40; B c ...... |
Chromosomal Location | 20q12-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD40. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CD40 |
Name | CD40 molecule, TNF receptor superfamily member 5 |
Aliases | Bp50; TNFRSF5; tumor necrosis factor receptor superfamily, member 5; CDW40; B cell surface antigen CD40; B c ...... |
Chromosomal Location | 20q12-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD40. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD40. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CD40 |
Name | CD40 molecule, TNF receptor superfamily member 5 |
Aliases | Bp50; TNFRSF5; tumor necrosis factor receptor superfamily, member 5; CDW40; B cell surface antigen CD40; B c ...... |
Chromosomal Location | 20q12-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD40. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CD40 |
Name | CD40 molecule, TNF receptor superfamily member 5 |
Aliases | Bp50; TNFRSF5; tumor necrosis factor receptor superfamily, member 5; CDW40; B cell surface antigen CD40; B c ...... |
Chromosomal Location | 20q12-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD40 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CD40 |
Name | CD40 molecule, TNF receptor superfamily member 5 |
Aliases | Bp50; TNFRSF5; tumor necrosis factor receptor superfamily, member 5; CDW40; B cell surface antigen CD40; B c ...... |
Chromosomal Location | 20q12-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD40 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CD40 |
Name | CD40 molecule, TNF receptor superfamily member 5 |
Aliases | Bp50; TNFRSF5; tumor necrosis factor receptor superfamily, member 5; CDW40; B cell surface antigen CD40; B c ...... |
Chromosomal Location | 20q12-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD40 collected from DrugBank database. |
Details on drugs targeting CD40.
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