Summary | |
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Symbol | CD44 |
Name | CD44 molecule (Indian blood group) |
Aliases | IN; MC56; Pgp1; CD44R; HCELL; CSPG8; hematopoietic cell E- and L-selectin ligand; chondroitin sulfate proteo ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Cell projection, microvillus Note=Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli. |
Domain |
PF00193 Extracellular link domain |
Function |
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). |
Biological Process |
GO:0001501 skeletal system development GO:0006022 aminoglycan metabolic process GO:0006026 aminoglycan catabolic process GO:0006027 glycosaminoglycan catabolic process GO:0007159 leukocyte cell-cell adhesion GO:0007160 cell-matrix adhesion GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0018105 peptidyl-serine phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018209 peptidyl-serine modification GO:0018212 peptidyl-tyrosine modification GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0022617 extracellular matrix disassembly GO:0030198 extracellular matrix organization GO:0030203 glycosaminoglycan metabolic process GO:0030212 hyaluronan metabolic process GO:0030214 hyaluronan catabolic process GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0031589 cell-substrate adhesion GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0034113 heterotypic cell-cell adhesion GO:0034114 regulation of heterotypic cell-cell adhesion GO:0034116 positive regulation of heterotypic cell-cell adhesion GO:0034341 response to interferon-gamma GO:0042770 signal transduction in response to DNA damage GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0043062 extracellular structure organization GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043410 positive regulation of MAPK cascade GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0044344 cellular response to fibroblast growth factor stimulus GO:0045785 positive regulation of cell adhesion GO:0045861 negative regulation of proteolysis GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050900 leukocyte migration GO:0051216 cartilage development GO:0051346 negative regulation of hydrolase activity GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060333 interferon-gamma-mediated signaling pathway GO:0061448 connective tissue development GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070486 leukocyte aggregation GO:0070487 monocyte aggregation GO:0071346 cellular response to interferon-gamma GO:0071774 response to fibroblast growth factor GO:0072331 signal transduction by p53 class mediator GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator GO:0097193 intrinsic apoptotic signaling pathway GO:1900623 regulation of monocyte aggregation GO:1900625 positive regulation of monocyte aggregation GO:1901136 carbohydrate derivative catabolic process GO:1901565 organonitrogen compound catabolic process GO:1901796 regulation of signal transduction by p53 class mediator GO:1901797 negative regulation of signal transduction by p53 class mediator GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902532 negative regulation of intracellular signal transduction GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903510 mucopolysaccharide metabolic process GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0004896 cytokine receptor activity GO:0005518 collagen binding GO:0005539 glycosaminoglycan binding GO:0005540 hyaluronic acid binding |
Cellular Component |
GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction GO:0035692 macrophage migration inhibitory factor receptor complex GO:0043235 receptor complex |
KEGG |
hsa04512 ECM-receptor interaction hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1474228: Degradation of the extracellular matrix R-HSA-1474244: Extracellular matrix organization R-HSA-74160: Gene Expression R-HSA-1630316: Glycosaminoglycan metabolism R-HSA-109582: Hemostasis R-HSA-2142845: Hyaluronan metabolism R-HSA-2160916: Hyaluronan uptake and degradation R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-428359: Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-216083: Integrin cell surface interactions R-HSA-913531: Interferon Signaling R-HSA-877300: Interferon gamma signaling R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates R-HSA-6798695: Neutrophil degranulation |
Summary | |
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Symbol | CD44 |
Name | CD44 molecule (Indian blood group) |
Aliases | IN; MC56; Pgp1; CD44R; HCELL; CSPG8; hematopoietic cell E- and L-selectin ligand; chondroitin sulfate proteo ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD44 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CD44 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CD44 |
Name | CD44 molecule (Indian blood group) |
Aliases | IN; MC56; Pgp1; CD44R; HCELL; CSPG8; hematopoietic cell E- and L-selectin ligand; chondroitin sulfate proteo ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD44 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CD44 |
Name | CD44 molecule (Indian blood group) |
Aliases | IN; MC56; Pgp1; CD44R; HCELL; CSPG8; hematopoietic cell E- and L-selectin ligand; chondroitin sulfate proteo ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD44 in various data sets.
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Points in the above scatter plot represent the mutation difference of CD44 in various data sets.
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Summary | |
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Symbol | CD44 |
Name | CD44 molecule (Indian blood group) |
Aliases | IN; MC56; Pgp1; CD44R; HCELL; CSPG8; hematopoietic cell E- and L-selectin ligand; chondroitin sulfate proteo ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD44. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CD44 |
Name | CD44 molecule (Indian blood group) |
Aliases | IN; MC56; Pgp1; CD44R; HCELL; CSPG8; hematopoietic cell E- and L-selectin ligand; chondroitin sulfate proteo ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD44. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD44. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CD44 |
Name | CD44 molecule (Indian blood group) |
Aliases | IN; MC56; Pgp1; CD44R; HCELL; CSPG8; hematopoietic cell E- and L-selectin ligand; chondroitin sulfate proteo ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD44. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CD44 |
Name | CD44 molecule (Indian blood group) |
Aliases | IN; MC56; Pgp1; CD44R; HCELL; CSPG8; hematopoietic cell E- and L-selectin ligand; chondroitin sulfate proteo ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD44 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CD44 |
Name | CD44 molecule (Indian blood group) |
Aliases | IN; MC56; Pgp1; CD44R; HCELL; CSPG8; hematopoietic cell E- and L-selectin ligand; chondroitin sulfate proteo ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD44 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CD44 |
Name | CD44 molecule (Indian blood group) |
Aliases | IN; MC56; Pgp1; CD44R; HCELL; CSPG8; hematopoietic cell E- and L-selectin ligand; chondroitin sulfate proteo ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD44 collected from DrugBank database. |
Details on drugs targeting CD44.
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