Summary | |
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Symbol | CD47 |
Name | CD47 molecule |
Aliases | antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; integrin associate ...... |
Chromosomal Location | 3q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein |
Domain |
PF04549 CD47 transmembrane region PF08204 CD47 immunoglobulin-like domain |
Function |
Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. |
Biological Process |
GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0006909 phagocytosis GO:0007159 leukocyte cell-cell adhesion GO:0007229 integrin-mediated signaling pathway GO:0008228 opsonization GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030100 regulation of endocytosis GO:0030198 extracellular matrix organization GO:0031349 positive regulation of defense response GO:0032103 positive regulation of response to external stimulus GO:0042110 T cell activation GO:0043062 extracellular structure organization GO:0045785 positive regulation of cell adhesion GO:0045807 positive regulation of endocytosis GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050764 regulation of phagocytosis GO:0050766 positive regulation of phagocytosis GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050900 leukocyte migration GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0060627 regulation of vesicle-mediated transport GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071593 lymphocyte aggregation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion |
Molecular Function |
GO:0070053 thrombospondin receptor activity |
Cellular Component | - |
KEGG |
hsa04512 ECM-receptor interaction |
Reactome |
R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-1500931: Cell-Cell communication R-HSA-1474244: Extracellular matrix organization R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-216083: Integrin cell surface interactions R-HSA-6798695: Neutrophil degranulation R-HSA-391160: Signal regulatory protein (SIRP) family interactions |
Summary | |
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Symbol | CD47 |
Name | CD47 molecule |
Aliases | antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; integrin associate ...... |
Chromosomal Location | 3q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD47 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CD47 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CD47 |
Name | CD47 molecule |
Aliases | antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; integrin associate ...... |
Chromosomal Location | 3q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD47 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CD47 |
Name | CD47 molecule |
Aliases | antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; integrin associate ...... |
Chromosomal Location | 3q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD47 in various data sets.
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Points in the above scatter plot represent the mutation difference of CD47 in various data sets.
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Summary | |
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Symbol | CD47 |
Name | CD47 molecule |
Aliases | antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; integrin associate ...... |
Chromosomal Location | 3q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD47. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CD47 |
Name | CD47 molecule |
Aliases | antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; integrin associate ...... |
Chromosomal Location | 3q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD47. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD47. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CD47 |
Name | CD47 molecule |
Aliases | antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; integrin associate ...... |
Chromosomal Location | 3q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD47. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CD47 |
Name | CD47 molecule |
Aliases | antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; integrin associate ...... |
Chromosomal Location | 3q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD47 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CD47 |
Name | CD47 molecule |
Aliases | antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; integrin associate ...... |
Chromosomal Location | 3q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD47 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CD47 |
Name | CD47 molecule |
Aliases | antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; integrin associate ...... |
Chromosomal Location | 3q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD47 collected from DrugBank database. |
There is no record. |