Summary | |
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Symbol | CD59 |
Name | CD59 molecule, complement regulatory protein |
Aliases | 16.3A5; EJ16; EJ30; EL32; G344; p18-20; MIC11; MIN1; MSK21; MIN2; MIN3; CD59 antigen p18-20 (antigen identif ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Soluble form found in a number of tissues. |
Domain |
PF00021 u-PAR/Ly-6 domain |
Function |
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.; FUNCTION: The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. |
Biological Process |
GO:0001905 activation of membrane attack complex GO:0001969 regulation of activation of membrane attack complex GO:0001971 negative regulation of activation of membrane attack complex GO:0002526 acute inflammatory response GO:0002673 regulation of acute inflammatory response GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002920 regulation of humoral immune response GO:0002921 negative regulation of humoral immune response GO:0006888 ER to Golgi vesicle-mediated transport GO:0006900 membrane budding GO:0006901 vesicle coating GO:0006903 vesicle targeting GO:0006956 complement activation GO:0006959 humoral immune response GO:0007159 leukocyte cell-cell adhesion GO:0007596 blood coagulation GO:0007599 hemostasis GO:0010955 negative regulation of protein processing GO:0016050 vesicle organization GO:0016485 protein processing GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030449 regulation of complement activation GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0042098 T cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0045785 positive regulation of cell adhesion GO:0045861 negative regulation of proteolysis GO:0045916 negative regulation of complement activation GO:0046651 lymphocyte proliferation GO:0048193 Golgi vesicle transport GO:0048199 vesicle targeting, to, from or within Golgi GO:0048207 vesicle targeting, rough ER to cis-Golgi GO:0048208 COPII vesicle coating GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050727 regulation of inflammatory response GO:0050777 negative regulation of immune response GO:0050817 coagulation GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050878 regulation of body fluid levels GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051604 protein maturation GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070613 regulation of protein processing GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071593 lymphocyte aggregation GO:0072376 protein activation cascade GO:0090114 COPII-coated vesicle budding GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903317 regulation of protein maturation GO:1903318 negative regulation of protein maturation GO:2000257 regulation of protein activation cascade GO:2000258 negative regulation of protein activation cascade |
Molecular Function |
GO:0001848 complement binding |
Cellular Component |
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0009897 external side of plasma membrane GO:0012507 ER to Golgi transport vesicle membrane GO:0030055 cell-substrate junction GO:0030133 transport vesicle GO:0030134 ER to Golgi transport vesicle GO:0030135 coated vesicle GO:0030658 transport vesicle membrane GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0031225 anchored component of membrane GO:0031233 intrinsic component of external side of plasma membrane GO:0031362 anchored component of external side of plasma membrane GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0042383 sarcolemma GO:0043209 myelin sheath GO:0043218 compact myelin GO:0046658 anchored component of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04610 Complement and coagulation cascades hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-6807878: COPI-mediated anterograde transport R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport R-HSA-5694530: Cargo concentration in the ER R-HSA-166658: Complement cascade R-HSA-199977: ER to Golgi Anterograde Transport R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-6798695: Neutrophil degranulation R-HSA-597592: Post-translational protein modification R-HSA-977606: Regulation of Complement cascade R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | CD59 |
Name | CD59 molecule, complement regulatory protein |
Aliases | 16.3A5; EJ16; EJ30; EL32; G344; p18-20; MIC11; MIN1; MSK21; MIN2; MIN3; CD59 antigen p18-20 (antigen identif ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD59 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CD59 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CD59 |
Name | CD59 molecule, complement regulatory protein |
Aliases | 16.3A5; EJ16; EJ30; EL32; G344; p18-20; MIC11; MIN1; MSK21; MIN2; MIN3; CD59 antigen p18-20 (antigen identif ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD59 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CD59 |
Name | CD59 molecule, complement regulatory protein |
Aliases | 16.3A5; EJ16; EJ30; EL32; G344; p18-20; MIC11; MIN1; MSK21; MIN2; MIN3; CD59 antigen p18-20 (antigen identif ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD59 in various data sets.
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Points in the above scatter plot represent the mutation difference of CD59 in various data sets.
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Summary | |
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Symbol | CD59 |
Name | CD59 molecule, complement regulatory protein |
Aliases | 16.3A5; EJ16; EJ30; EL32; G344; p18-20; MIC11; MIN1; MSK21; MIN2; MIN3; CD59 antigen p18-20 (antigen identif ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD59. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CD59 |
Name | CD59 molecule, complement regulatory protein |
Aliases | 16.3A5; EJ16; EJ30; EL32; G344; p18-20; MIC11; MIN1; MSK21; MIN2; MIN3; CD59 antigen p18-20 (antigen identif ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD59. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD59. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CD59 |
Name | CD59 molecule, complement regulatory protein |
Aliases | 16.3A5; EJ16; EJ30; EL32; G344; p18-20; MIC11; MIN1; MSK21; MIN2; MIN3; CD59 antigen p18-20 (antigen identif ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD59. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CD59 |
Name | CD59 molecule, complement regulatory protein |
Aliases | 16.3A5; EJ16; EJ30; EL32; G344; p18-20; MIC11; MIN1; MSK21; MIN2; MIN3; CD59 antigen p18-20 (antigen identif ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD59 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CD59 |
Name | CD59 molecule, complement regulatory protein |
Aliases | 16.3A5; EJ16; EJ30; EL32; G344; p18-20; MIC11; MIN1; MSK21; MIN2; MIN3; CD59 antigen p18-20 (antigen identif ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD59 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CD59 |
Name | CD59 molecule, complement regulatory protein |
Aliases | 16.3A5; EJ16; EJ30; EL32; G344; p18-20; MIC11; MIN1; MSK21; MIN2; MIN3; CD59 antigen p18-20 (antigen identif ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD59 collected from DrugBank database. |
There is no record. |