Summary | |
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Symbol | CD83 |
Name | CD83 molecule |
Aliases | HB15; BL11; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily); B-cell activation protein; c ...... |
Chromosomal Location | 6p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF07686 Immunoglobulin V-set domain |
Function |
May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation. |
Biological Process |
GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0002521 leukocyte differentiation GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0006959 humoral immune response GO:0007159 leukocyte cell-cell adhesion GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0032613 interleukin-10 production GO:0032623 interleukin-2 production GO:0032633 interleukin-4 production GO:0032653 regulation of interleukin-10 production GO:0032663 regulation of interleukin-2 production GO:0032673 regulation of interleukin-4 production GO:0032713 negative regulation of interleukin-4 production GO:0032733 positive regulation of interleukin-10 production GO:0032743 positive regulation of interleukin-2 production GO:0035710 CD4-positive, alpha-beta T cell activation GO:0042110 T cell activation GO:0043367 CD4-positive, alpha-beta T cell differentiation GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation GO:0045580 regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045785 positive regulation of cell adhesion GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0046634 regulation of alpha-beta T cell activation GO:0046635 positive regulation of alpha-beta T cell activation GO:0046637 regulation of alpha-beta T cell differentiation GO:0046638 positive regulation of alpha-beta T cell differentiation GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071593 lymphocyte aggregation GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:2000514 regulation of CD4-positive, alpha-beta T cell activation GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation |
Molecular Function | - |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | CD83 |
Name | CD83 molecule |
Aliases | HB15; BL11; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily); B-cell activation protein; c ...... |
Chromosomal Location | 6p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD83 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CD83 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CD83 |
Name | CD83 molecule |
Aliases | HB15; BL11; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily); B-cell activation protein; c ...... |
Chromosomal Location | 6p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD83 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CD83 |
Name | CD83 molecule |
Aliases | HB15; BL11; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily); B-cell activation protein; c ...... |
Chromosomal Location | 6p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD83 in various data sets.
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Points in the above scatter plot represent the mutation difference of CD83 in various data sets.
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Summary | |
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Symbol | CD83 |
Name | CD83 molecule |
Aliases | HB15; BL11; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily); B-cell activation protein; c ...... |
Chromosomal Location | 6p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD83. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CD83 |
Name | CD83 molecule |
Aliases | HB15; BL11; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily); B-cell activation protein; c ...... |
Chromosomal Location | 6p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD83. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD83. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CD83 |
Name | CD83 molecule |
Aliases | HB15; BL11; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily); B-cell activation protein; c ...... |
Chromosomal Location | 6p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD83. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CD83 |
Name | CD83 molecule |
Aliases | HB15; BL11; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily); B-cell activation protein; c ...... |
Chromosomal Location | 6p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD83 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CD83 |
Name | CD83 molecule |
Aliases | HB15; BL11; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily); B-cell activation protein; c ...... |
Chromosomal Location | 6p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD83 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CD83 |
Name | CD83 molecule |
Aliases | HB15; BL11; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily); B-cell activation protein; c ...... |
Chromosomal Location | 6p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD83 collected from DrugBank database. |
There is no record. |