Summary | |
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Symbol | CD8A |
Name | CD8a molecule |
Aliases | CD8; CD8 antigen, alpha polypeptide (p32); T-cell surface glycoprotein CD8 alpha chain; Leu2 T-lymphocyte an ...... |
Chromosomal Location | 2p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cell membrane Single-pass type I membrane protein. Note=CD8A localizes to lipid rafts only when associated with its partner CD8B. ; SUBCELLULAR LOCATION: Isoform 2: Secreted |
Domain |
PF07686 Immunoglobulin V-set domain |
Function |
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. |
Biological Process |
GO:0002250 adaptive immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0007159 leukocyte cell-cell adhesion GO:0009615 response to virus GO:0019722 calcium-mediated signaling GO:0019882 antigen processing and presentation GO:0019932 second-messenger-mediated signaling GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0042110 T cell activation GO:0045065 cytotoxic T cell differentiation GO:0050848 regulation of calcium-mediated signaling GO:0050850 positive regulation of calcium-mediated signaling GO:0051607 defense response to virus GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071593 lymphocyte aggregation GO:0098542 defense response to other organism |
Molecular Function |
GO:0015026 coreceptor activity GO:0042287 MHC protein binding GO:0042288 MHC class I protein binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0042101 T cell receptor complex GO:0043235 receptor complex GO:0098552 side of membrane GO:0098802 plasma membrane receptor complex |
KEGG |
hsa04514 Cell adhesion molecules (CAMs) hsa04612 Antigen processing and presentation hsa04640 Hematopoietic cell lineage hsa04660 T cell receptor signaling pathway |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Summary | |
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Symbol | CD8A |
Name | CD8a molecule |
Aliases | CD8; CD8 antigen, alpha polypeptide (p32); T-cell surface glycoprotein CD8 alpha chain; Leu2 T-lymphocyte an ...... |
Chromosomal Location | 2p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD8A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CD8A and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CD8A |
Name | CD8a molecule |
Aliases | CD8; CD8 antigen, alpha polypeptide (p32); T-cell surface glycoprotein CD8 alpha chain; Leu2 T-lymphocyte an ...... |
Chromosomal Location | 2p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD8A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CD8A |
Name | CD8a molecule |
Aliases | CD8; CD8 antigen, alpha polypeptide (p32); T-cell surface glycoprotein CD8 alpha chain; Leu2 T-lymphocyte an ...... |
Chromosomal Location | 2p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD8A in various data sets.
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Points in the above scatter plot represent the mutation difference of CD8A in various data sets.
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Summary | |
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Symbol | CD8A |
Name | CD8a molecule |
Aliases | CD8; CD8 antigen, alpha polypeptide (p32); T-cell surface glycoprotein CD8 alpha chain; Leu2 T-lymphocyte an ...... |
Chromosomal Location | 2p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD8A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CD8A |
Name | CD8a molecule |
Aliases | CD8; CD8 antigen, alpha polypeptide (p32); T-cell surface glycoprotein CD8 alpha chain; Leu2 T-lymphocyte an ...... |
Chromosomal Location | 2p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD8A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD8A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CD8A |
Name | CD8a molecule |
Aliases | CD8; CD8 antigen, alpha polypeptide (p32); T-cell surface glycoprotein CD8 alpha chain; Leu2 T-lymphocyte an ...... |
Chromosomal Location | 2p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD8A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CD8A |
Name | CD8a molecule |
Aliases | CD8; CD8 antigen, alpha polypeptide (p32); T-cell surface glycoprotein CD8 alpha chain; Leu2 T-lymphocyte an ...... |
Chromosomal Location | 2p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD8A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CD8A |
Name | CD8a molecule |
Aliases | CD8; CD8 antigen, alpha polypeptide (p32); T-cell surface glycoprotein CD8 alpha chain; Leu2 T-lymphocyte an ...... |
Chromosomal Location | 2p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD8A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CD8A |
Name | CD8a molecule |
Aliases | CD8; CD8 antigen, alpha polypeptide (p32); T-cell surface glycoprotein CD8 alpha chain; Leu2 T-lymphocyte an ...... |
Chromosomal Location | 2p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD8A collected from DrugBank database. |
There is no record. |