Browse CD99

Summary
SymbolCD99
NameCD99 molecule
Aliases MIC2; antigen identified by monoclonal antibodies 12E7, F21 and O13; CD99 antigen; HBA71; MIC2X; MIC2Y; MSK5 ......
Chromosomal LocationXp22.32 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Single-pass type I membrane protein
Domain PF12301 CD99 antigen like protein 2
Function

Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).

> Gene Ontology
 
Biological Process -
Molecular Function -
Cellular Component GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0030055 cell-substrate junction
> KEGG and Reactome Pathway
 
KEGG hsa04514 Cell adhesion molecules (CAMs)
hsa04670 Leukocyte transendothelial migration
Reactome R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-109582: Hemostasis
Summary
SymbolCD99
NameCD99 molecule
Aliases MIC2; antigen identified by monoclonal antibodies 12E7, F21 and O13; CD99 antigen; HBA71; MIC2X; MIC2Y; MSK5 ......
Chromosomal LocationXp22.32 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CD99 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CD99 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29637789Acute myeloid leukemiaInhibit immunityExpert opinion/commentary: Cytotoxic CD99 monoclonal antibodies represent promising stem cell-directed therapies that have the potential to markedly improve clinical outcomes for these difficult-to-treat hematologic malignancies.
Summary
SymbolCD99
NameCD99 molecule
Aliases MIC2; antigen identified by monoclonal antibodies 12E7, F21 and O13; CD99 antigen; HBA71; MIC2X; MIC2Y; MSK5 ......
Chromosomal LocationXp22.32 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CD99 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCD99
NameCD99 molecule
Aliases MIC2; antigen identified by monoclonal antibodies 12E7, F21 and O13; CD99 antigen; HBA71; MIC2X; MIC2Y; MSK5 ......
Chromosomal LocationXp22.32 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CD99 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0040.992
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1380.948
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1860.947
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3370.574
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3220.892
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4260.876
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4670.837
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2350.72
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0220.853
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CD99 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCD99
NameCD99 molecule
Aliases MIC2; antigen identified by monoclonal antibodies 12E7, F21 and O13; CD99 antigen; HBA71; MIC2X; MIC2Y; MSK5 ......
Chromosomal LocationXp22.32 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD99. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCD99
NameCD99 molecule
Aliases MIC2; antigen identified by monoclonal antibodies 12E7, F21 and O13; CD99 antigen; HBA71; MIC2X; MIC2Y; MSK5 ......
Chromosomal LocationXp22.32 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD99. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD99.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCD99
NameCD99 molecule
Aliases MIC2; antigen identified by monoclonal antibodies 12E7, F21 and O13; CD99 antigen; HBA71; MIC2X; MIC2Y; MSK5 ......
Chromosomal LocationXp22.32 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD99. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCD99
NameCD99 molecule
Aliases MIC2; antigen identified by monoclonal antibodies 12E7, F21 and O13; CD99 antigen; HBA71; MIC2X; MIC2Y; MSK5 ......
Chromosomal LocationXp22.32 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CD99 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCD99
NameCD99 molecule
Aliases MIC2; antigen identified by monoclonal antibodies 12E7, F21 and O13; CD99 antigen; HBA71; MIC2X; MIC2Y; MSK5 ......
Chromosomal LocationXp22.32 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CD99 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCD99
NameCD99 molecule
Aliases MIC2; antigen identified by monoclonal antibodies 12E7, F21 and O13; CD99 antigen; HBA71; MIC2X; MIC2Y; MSK5 ......
Chromosomal LocationXp22.32 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CD99 collected from DrugBank database.
> Drugs from DrugBank database
 

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