Browse CDC42

Summary
SymbolCDC42
Namecell division cycle 42
Aliases G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ......
Chromosomal Location1p36.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Lipid-anchor Cytoplasmic side Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Midbody Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase (PubMed:15642749). Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells (PubMed:15642749). Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1 (PubMed:15642749). Colocalizes with NEK6 in the centrosome (PubMed:20873783). In its active GTP-bound form localizes to the leading edge membrane of migrating dendritic cells (By similarity).
Domain PF00071 Ras family
Function

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.

> Gene Ontology
 
Biological Process GO:0000910 cytokinesis
GO:0001525 angiogenesis
GO:0001558 regulation of cell growth
GO:0001709 cell fate determination
GO:0001736 establishment of planar polarity
GO:0001738 morphogenesis of a polarized epithelium
GO:0001942 hair follicle development
GO:0002040 sprouting angiogenesis
GO:0002064 epithelial cell development
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0002431 Fc receptor mediated stimulatory signaling pathway
GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
GO:0002521 leukocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002757 immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0003161 cardiac conduction system development
GO:0003334 keratinocyte development
GO:0006260 DNA replication
GO:0006275 regulation of DNA replication
GO:0006644 phospholipid metabolic process
GO:0006909 phagocytosis
GO:0007015 actin filament organization
GO:0007018 microtubule-based movement
GO:0007030 Golgi organization
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007088 regulation of mitotic nuclear division
GO:0007097 nuclear migration
GO:0007159 leukocyte cell-cell adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0007164 establishment of tissue polarity
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007254 JNK cascade
GO:0007346 regulation of mitotic cell cycle
GO:0007431 salivary gland development
GO:0007435 salivary gland morphogenesis
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008015 blood circulation
GO:0008544 epidermis development
GO:0008608 attachment of spindle microtubules to kinetochore
GO:0009894 regulation of catabolic process
GO:0009913 epidermal cell differentiation
GO:0010720 positive regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010770 positive regulation of cell morphogenesis involved in differentiation
GO:0010810 regulation of cell-substrate adhesion
GO:0010811 positive regulation of cell-substrate adhesion
GO:0010970 transport along microtubule
GO:0014706 striated muscle tissue development
GO:0016049 cell growth
GO:0016055 Wnt signaling pathway
GO:0018105 peptidyl-serine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0019058 viral life cycle
GO:0019079 viral genome replication
GO:0019216 regulation of lipid metabolic process
GO:0021762 substantia nigra development
GO:0022404 molting cycle process
GO:0022405 hair cycle process
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0022604 regulation of cell morphogenesis
GO:0022612 gland morphogenesis
GO:0030031 cell projection assembly
GO:0030099 myeloid cell differentiation
GO:0030216 keratinocyte differentiation
GO:0030225 macrophage differentiation
GO:0030307 positive regulation of cell growth
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030705 cytoskeleton-dependent intracellular transport
GO:0030901 midbrain development
GO:0031069 hair follicle morphogenesis
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031268 pseudopodium organization
GO:0031269 pseudopodium assembly
GO:0031272 regulation of pseudopodium assembly
GO:0031274 positive regulation of pseudopodium assembly
GO:0031294 lymphocyte costimulation
GO:0031295 T cell costimulation
GO:0031333 negative regulation of protein complex assembly
GO:0031346 positive regulation of cell projection organization
GO:0031424 keratinization
GO:0031589 cell-substrate adhesion
GO:0031647 regulation of protein stability
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032465 regulation of cytokinesis
GO:0032467 positive regulation of cytokinesis
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033157 regulation of intracellular protein transport
GO:0033674 positive regulation of kinase activity
GO:0034330 cell junction organization
GO:0034332 adherens junction organization
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035088 establishment or maintenance of apical/basal cell polarity
GO:0035264 multicellular organism growth
GO:0035272 exocrine system development
GO:0035567 non-canonical Wnt signaling pathway
GO:0036336 dendritic cell migration
GO:0038093 Fc receptor signaling pathway
GO:0038094 Fc-gamma receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038127 ERBB signaling pathway
GO:0039694 viral RNA genome replication
GO:0039703 RNA replication
GO:0040023 establishment of nucleus localization
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042110 T cell activation
GO:0042176 regulation of protein catabolic process
GO:0042303 molting cycle
GO:0042633 hair cycle
GO:0042692 muscle cell differentiation
GO:0043254 regulation of protein complex assembly
GO:0043393 regulation of protein binding
GO:0043410 positive regulation of MAPK cascade
GO:0043497 regulation of protein heterodimerization activity
GO:0043523 regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043550 regulation of lipid kinase activity
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043588 skin development
GO:0044033 multi-organism metabolic process
GO:0044089 positive regulation of cellular component biogenesis
GO:0045165 cell fate commitment
GO:0045216 cell-cell junction organization
GO:0045740 positive regulation of DNA replication
GO:0045785 positive regulation of cell adhesion
GO:0045787 positive regulation of cell cycle
GO:0045834 positive regulation of lipid metabolic process
GO:0045927 positive regulation of growth
GO:0046328 regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0046847 filopodium assembly
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0048663 neuron fate commitment
GO:0048664 neuron fate determination
GO:0048730 epidermis morphogenesis
GO:0048732 gland development
GO:0048738 cardiac muscle tissue development
GO:0048857 neural nucleus development
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050803 regulation of synapse structure or activity
GO:0050807 regulation of synapse organization
GO:0050808 synapse organization
GO:0050817 coagulation
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050870 positive regulation of T cell activation
GO:0050878 regulation of body fluid levels
GO:0050900 leukocyte migration
GO:0051017 actin filament bundle assembly
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051098 regulation of binding
GO:0051147 regulation of muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051222 positive regulation of protein transport
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051302 regulation of cell division
GO:0051402 neuron apoptotic process
GO:0051403 stress-activated MAPK cascade
GO:0051489 regulation of filopodium assembly
GO:0051640 organelle localization
GO:0051645 Golgi localization
GO:0051647 nucleus localization
GO:0051656 establishment of organelle localization
GO:0051683 establishment of Golgi localization
GO:0051781 positive regulation of cell division
GO:0051783 regulation of nuclear division
GO:0051823 regulation of synapse structural plasticity
GO:0051835 positive regulation of synapse structural plasticity
GO:0051983 regulation of chromosome segregation
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
GO:0060047 heart contraction
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060425 lung morphogenesis
GO:0060428 lung epithelium development
GO:0060491 regulation of cell projection assembly
GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060537 muscle tissue development
GO:0060541 respiratory system development
GO:0060661 submandibular salivary gland formation
GO:0060684 epithelial-mesenchymal cell signaling
GO:0060788 ectodermal placode formation
GO:0060789 hair follicle placode formation
GO:0061245 establishment or maintenance of bipolar cell polarity
GO:0061572 actin filament bundle organization
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070997 neuron death
GO:0071335 hair follicle cell proliferation
GO:0071336 regulation of hair follicle cell proliferation
GO:0071338 positive regulation of hair follicle cell proliferation
GO:0071593 lymphocyte aggregation
GO:0071696 ectodermal placode development
GO:0071697 ectodermal placode morphogenesis
GO:0072384 organelle transport along microtubule
GO:0090068 positive regulation of cell cycle process
GO:0090135 actin filament branching
GO:0090136 epithelial cell-cell adhesion
GO:0090175 regulation of establishment of planar polarity
GO:0090218 positive regulation of lipid kinase activity
GO:0090316 positive regulation of intracellular protein transport
GO:0098773 skin epidermis development
GO:0098813 nuclear chromosome segregation
GO:0198738 cell-cell signaling by wnt
GO:1900024 regulation of substrate adhesion-dependent cell spreading
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1901184 regulation of ERBB signaling pathway
GO:1901185 negative regulation of ERBB signaling pathway
GO:1901214 regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903725 regulation of phospholipid metabolic process
GO:1903727 positive regulation of phospholipid metabolic process
GO:1903829 positive regulation of cellular protein localization
GO:1904951 positive regulation of establishment of protein localization
GO:1905330 regulation of morphogenesis of an epithelium
GO:2000027 regulation of organ morphogenesis
GO:2000794 regulation of epithelial cell proliferation involved in lung morphogenesis
Molecular Function GO:0003924 GTPase activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0019787 ubiquitin-like protein transferase activity
GO:0030742 GTP-dependent protein binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0031996 thioesterase binding
GO:0032561 guanyl ribonucleotide binding
GO:0034190 apolipoprotein receptor binding
GO:0034191 apolipoprotein A-I receptor binding
GO:0051021 GDP-dissociation inhibitor binding
GO:0051022 Rho GDP-dissociation inhibitor binding
GO:0061630 ubiquitin protein ligase activity
GO:0061659 ubiquitin-like protein ligase activity
Cellular Component GO:0000322 storage vacuole
GO:0005819 spindle
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0030055 cell-substrate junction
GO:0030141 secretory granule
GO:0030175 filopodium
GO:0030496 midbody
GO:0031252 cell leading edge
GO:0031256 leading edge membrane
GO:0035770 ribonucleoprotein granule
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043025 neuronal cell body
GO:0043209 myelin sheath
GO:0044297 cell body
GO:0045177 apical part of cell
GO:0051233 spindle midzone
GO:0072686 mitotic spindle
GO:0098858 actin-based cell projection
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04062 Chemokine signaling pathway
hsa04144 Endocytosis
hsa04360 Axon guidance
hsa04370 VEGF signaling pathway
hsa04510 Focal adhesion
hsa04520 Adherens junction
hsa04530 Tight junction
hsa04660 T cell receptor signaling pathway
hsa04666 Fc gamma R-mediated phagocytosis
hsa04670 Leukocyte transendothelial migration
hsa04722 Neurotrophin signaling pathway
hsa04810 Regulation of actin cytoskeleton
hsa04912 GnRH signaling pathway
Reactome R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-389356: CD28 co-stimulation
R-HSA-389359: CD28 dependent Vav1 pathway
R-HSA-375170: CDO in myogenesis
R-HSA-388841: Costimulation by the CD28 family
R-HSA-418885: DCC mediated attractive signaling
R-HSA-1266738: Developmental Biology
R-HSA-182971: EGFR downregulation
R-HSA-2682334: EPH-Ephrin signaling
R-HSA-3928662: EPHB-mediated forward signaling
R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-416482: G alpha (12/13) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-114604: GPVI-mediated activation cascade
R-HSA-109582: Hemostasis
R-HSA-168256: Immune System
R-HSA-428543: Inactivation of Cdc42 and Rac
R-HSA-168249: Innate Immune System
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5687128: MAPK6/MAPK4 signaling
R-HSA-525793: Myogenesis
R-HSA-373752: Netrin-1 signaling
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-195258: RHO GTPase Effectors
R-HSA-5663220: RHO GTPases Activate Formins
R-HSA-5663213: RHO GTPases Activate WASPs and WAVEs
R-HSA-5626467: RHO GTPases activate IQGAPs
R-HSA-5625970: RHO GTPases activate KTN1
R-HSA-5627123: RHO GTPases activate PAKs
R-HSA-2029482: Regulation of actin dynamics for phagocytic cup formation
R-HSA-194840: Rho GTPase cycle
R-HSA-400685: Sema4D in semaphorin signaling
R-HSA-416572: Sema4D induced cell migration and growth-cone collapse
R-HSA-373755: Semaphorin interactions
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-372790: Signaling by GPCR
R-HSA-194315: Signaling by Rho GTPases
R-HSA-376176: Signaling by Robo receptor
R-HSA-194138: Signaling by VEGF
R-HSA-4420097: VEGFA-VEGFR2 Pathway
Summary
SymbolCDC42
Namecell division cycle 42
Aliases G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ......
Chromosomal Location1p36.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CDC42 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CDC42 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
17971488Colorectal CarcinomaInhibit immunity (T cell function)We have identified Cdc42, a GTPase regulating actin dynamics and growth factor signaling that is highly expressed in invasive cancers, as determinator of cancer cell susceptibility to antigen-specific CTLs in vitro and adoptively transferred immune effectors in vivo. Cdc42 prevents CTL-induced apoptosis via mitogen-activated protein kinase (MAPK) signaling and posttranscriptional stabilization of Bcl-2. Pharmacologic inhibition of MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) overcomes Cdc42-mediated immunoresistance and activation of Bcl-2 in vivo.
Summary
SymbolCDC42
Namecell division cycle 42
Aliases G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ......
Chromosomal Location1p36.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CDC42 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCDC42
Namecell division cycle 42
Aliases G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ......
Chromosomal Location1p36.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CDC42 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1020.595
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1380.968
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2730.91
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1730.559
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.040.986
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4420.874
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.010.985
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0720.975
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.070.978
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2610.906
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5260.88
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0890.12
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CDC42 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCDC42
Namecell division cycle 42
Aliases G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ......
Chromosomal Location1p36.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDC42. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCDC42
Namecell division cycle 42
Aliases G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ......
Chromosomal Location1p36.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDC42. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDC42.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCDC42
Namecell division cycle 42
Aliases G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ......
Chromosomal Location1p36.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDC42. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCDC42
Namecell division cycle 42
Aliases G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ......
Chromosomal Location1p36.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CDC42 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCDC42
Namecell division cycle 42
Aliases G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ......
Chromosomal Location1p36.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CDC42 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCDC42
Namecell division cycle 42
Aliases G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ......
Chromosomal Location1p36.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CDC42 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CDC42.
ID Name Drug Type Targets #Targets
DB02623Aminophosphonic Acid-Guanylate EsterSmall MoleculeCDC421
DB04315Guanosine-5'-DiphosphateSmall MoleculeADSSL1, ARF1, ARF4, ARF6, ARL1, ARL3, ARL5A, ARL5B, CDC42, EEF1A1, ......36