Summary | |
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Symbol | CDC42 |
Name | cell division cycle 42 |
Aliases | G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ...... |
Chromosomal Location | 1p36.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor Cytoplasmic side Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Midbody Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase (PubMed:15642749). Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells (PubMed:15642749). Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1 (PubMed:15642749). Colocalizes with NEK6 in the centrosome (PubMed:20873783). In its active GTP-bound form localizes to the leading edge membrane of migrating dendritic cells (By similarity). |
Domain |
PF00071 Ras family |
Function |
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups. |
Biological Process |
GO:0000910 cytokinesis GO:0001525 angiogenesis GO:0001558 regulation of cell growth GO:0001709 cell fate determination GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0001942 hair follicle development GO:0002040 sprouting angiogenesis GO:0002064 epithelial cell development GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002431 Fc receptor mediated stimulatory signaling pathway GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0003013 circulatory system process GO:0003015 heart process GO:0003161 cardiac conduction system development GO:0003334 keratinocyte development GO:0006260 DNA replication GO:0006275 regulation of DNA replication GO:0006644 phospholipid metabolic process GO:0006909 phagocytosis GO:0007015 actin filament organization GO:0007018 microtubule-based movement GO:0007030 Golgi organization GO:0007059 chromosome segregation GO:0007067 mitotic nuclear division GO:0007088 regulation of mitotic nuclear division GO:0007097 nuclear migration GO:0007159 leukocyte cell-cell adhesion GO:0007163 establishment or maintenance of cell polarity GO:0007164 establishment of tissue polarity GO:0007173 epidermal growth factor receptor signaling pathway GO:0007254 JNK cascade GO:0007346 regulation of mitotic cell cycle GO:0007431 salivary gland development GO:0007435 salivary gland morphogenesis GO:0007507 heart development GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008015 blood circulation GO:0008544 epidermis development GO:0008608 attachment of spindle microtubules to kinetochore GO:0009894 regulation of catabolic process GO:0009913 epidermal cell differentiation GO:0010720 positive regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010770 positive regulation of cell morphogenesis involved in differentiation GO:0010810 regulation of cell-substrate adhesion GO:0010811 positive regulation of cell-substrate adhesion GO:0010970 transport along microtubule GO:0014706 striated muscle tissue development GO:0016049 cell growth GO:0016055 Wnt signaling pathway GO:0018105 peptidyl-serine phosphorylation GO:0018209 peptidyl-serine modification GO:0019058 viral life cycle GO:0019079 viral genome replication GO:0019216 regulation of lipid metabolic process GO:0021762 substantia nigra development GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0022604 regulation of cell morphogenesis GO:0022612 gland morphogenesis GO:0030031 cell projection assembly GO:0030099 myeloid cell differentiation GO:0030216 keratinocyte differentiation GO:0030225 macrophage differentiation GO:0030307 positive regulation of cell growth GO:0030323 respiratory tube development GO:0030324 lung development GO:0030705 cytoskeleton-dependent intracellular transport GO:0030901 midbrain development GO:0031069 hair follicle morphogenesis GO:0031098 stress-activated protein kinase signaling cascade GO:0031268 pseudopodium organization GO:0031269 pseudopodium assembly GO:0031272 regulation of pseudopodium assembly GO:0031274 positive regulation of pseudopodium assembly GO:0031294 lymphocyte costimulation GO:0031295 T cell costimulation GO:0031333 negative regulation of protein complex assembly GO:0031346 positive regulation of cell projection organization GO:0031424 keratinization GO:0031589 cell-substrate adhesion GO:0031647 regulation of protein stability GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032465 regulation of cytokinesis GO:0032467 positive regulation of cytokinesis GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033157 regulation of intracellular protein transport GO:0033674 positive regulation of kinase activity GO:0034330 cell junction organization GO:0034332 adherens junction organization GO:0034446 substrate adhesion-dependent cell spreading GO:0035088 establishment or maintenance of apical/basal cell polarity GO:0035264 multicellular organism growth GO:0035272 exocrine system development GO:0035567 non-canonical Wnt signaling pathway GO:0036336 dendritic cell migration GO:0038093 Fc receptor signaling pathway GO:0038094 Fc-gamma receptor signaling pathway GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038127 ERBB signaling pathway GO:0039694 viral RNA genome replication GO:0039703 RNA replication GO:0040023 establishment of nucleus localization GO:0042058 regulation of epidermal growth factor receptor signaling pathway GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway GO:0042110 T cell activation GO:0042176 regulation of protein catabolic process GO:0042303 molting cycle GO:0042633 hair cycle GO:0042692 muscle cell differentiation GO:0043254 regulation of protein complex assembly GO:0043393 regulation of protein binding GO:0043410 positive regulation of MAPK cascade GO:0043497 regulation of protein heterodimerization activity GO:0043523 regulation of neuron apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0043550 regulation of lipid kinase activity GO:0043551 regulation of phosphatidylinositol 3-kinase activity GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity GO:0043588 skin development GO:0044033 multi-organism metabolic process GO:0044089 positive regulation of cellular component biogenesis GO:0045165 cell fate commitment GO:0045216 cell-cell junction organization GO:0045740 positive regulation of DNA replication GO:0045785 positive regulation of cell adhesion GO:0045787 positive regulation of cell cycle GO:0045834 positive regulation of lipid metabolic process GO:0045927 positive regulation of growth GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0046847 filopodium assembly GO:0048010 vascular endothelial growth factor receptor signaling pathway GO:0048013 ephrin receptor signaling pathway GO:0048514 blood vessel morphogenesis GO:0048663 neuron fate commitment GO:0048664 neuron fate determination GO:0048730 epidermis morphogenesis GO:0048732 gland development GO:0048738 cardiac muscle tissue development GO:0048857 neural nucleus development GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050803 regulation of synapse structure or activity GO:0050807 regulation of synapse organization GO:0050808 synapse organization GO:0050817 coagulation GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050878 regulation of body fluid levels GO:0050900 leukocyte migration GO:0051017 actin filament bundle assembly GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051056 regulation of small GTPase mediated signal transduction GO:0051098 regulation of binding GO:0051147 regulation of muscle cell differentiation GO:0051149 positive regulation of muscle cell differentiation GO:0051222 positive regulation of protein transport GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051302 regulation of cell division GO:0051402 neuron apoptotic process GO:0051403 stress-activated MAPK cascade GO:0051489 regulation of filopodium assembly GO:0051640 organelle localization GO:0051645 Golgi localization GO:0051647 nucleus localization GO:0051656 establishment of organelle localization GO:0051683 establishment of Golgi localization GO:0051781 positive regulation of cell division GO:0051783 regulation of nuclear division GO:0051823 regulation of synapse structural plasticity GO:0051835 positive regulation of synapse structural plasticity GO:0051983 regulation of chromosome segregation GO:0051988 regulation of attachment of spindle microtubules to kinetochore GO:0060047 heart contraction GO:0060070 canonical Wnt signaling pathway GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0060425 lung morphogenesis GO:0060428 lung epithelium development GO:0060491 regulation of cell projection assembly GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060502 epithelial cell proliferation involved in lung morphogenesis GO:0060537 muscle tissue development GO:0060541 respiratory system development GO:0060661 submandibular salivary gland formation GO:0060684 epithelial-mesenchymal cell signaling GO:0060788 ectodermal placode formation GO:0060789 hair follicle placode formation GO:0061245 establishment or maintenance of bipolar cell polarity GO:0061572 actin filament bundle organization GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070997 neuron death GO:0071335 hair follicle cell proliferation GO:0071336 regulation of hair follicle cell proliferation GO:0071338 positive regulation of hair follicle cell proliferation GO:0071593 lymphocyte aggregation GO:0071696 ectodermal placode development GO:0071697 ectodermal placode morphogenesis GO:0072384 organelle transport along microtubule GO:0090068 positive regulation of cell cycle process GO:0090135 actin filament branching GO:0090136 epithelial cell-cell adhesion GO:0090175 regulation of establishment of planar polarity GO:0090218 positive regulation of lipid kinase activity GO:0090316 positive regulation of intracellular protein transport GO:0098773 skin epidermis development GO:0098813 nuclear chromosome segregation GO:0198738 cell-cell signaling by wnt GO:1900024 regulation of substrate adhesion-dependent cell spreading GO:1900026 positive regulation of substrate adhesion-dependent cell spreading GO:1901184 regulation of ERBB signaling pathway GO:1901185 negative regulation of ERBB signaling pathway GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903725 regulation of phospholipid metabolic process GO:1903727 positive regulation of phospholipid metabolic process GO:1903829 positive regulation of cellular protein localization GO:1904951 positive regulation of establishment of protein localization GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis GO:2000794 regulation of epithelial cell proliferation involved in lung morphogenesis |
Molecular Function |
GO:0003924 GTPase activity GO:0004842 ubiquitin-protein transferase activity GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0019787 ubiquitin-like protein transferase activity GO:0030742 GTP-dependent protein binding GO:0031435 mitogen-activated protein kinase kinase kinase binding GO:0031996 thioesterase binding GO:0032561 guanyl ribonucleotide binding GO:0034190 apolipoprotein receptor binding GO:0034191 apolipoprotein A-I receptor binding GO:0051021 GDP-dissociation inhibitor binding GO:0051022 Rho GDP-dissociation inhibitor binding GO:0061630 ubiquitin protein ligase activity GO:0061659 ubiquitin-like protein ligase activity |
Cellular Component |
GO:0000322 storage vacuole GO:0005819 spindle GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction GO:0030141 secretory granule GO:0030175 filopodium GO:0030496 midbody GO:0031252 cell leading edge GO:0031256 leading edge membrane GO:0035770 ribonucleoprotein granule GO:0036464 cytoplasmic ribonucleoprotein granule GO:0043025 neuronal cell body GO:0043209 myelin sheath GO:0044297 cell body GO:0045177 apical part of cell GO:0051233 spindle midzone GO:0072686 mitotic spindle GO:0098858 actin-based cell projection GO:0099503 secretory vesicle |
KEGG |
hsa04010 MAPK signaling pathway hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04062 Chemokine signaling pathway hsa04144 Endocytosis hsa04360 Axon guidance hsa04370 VEGF signaling pathway hsa04510 Focal adhesion hsa04520 Adherens junction hsa04530 Tight junction hsa04660 T cell receptor signaling pathway hsa04666 Fc gamma R-mediated phagocytosis hsa04670 Leukocyte transendothelial migration hsa04722 Neurotrophin signaling pathway hsa04810 Regulation of actin cytoskeleton hsa04912 GnRH signaling pathway |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-389356: CD28 co-stimulation R-HSA-389359: CD28 dependent Vav1 pathway R-HSA-375170: CDO in myogenesis R-HSA-388841: Costimulation by the CD28 family R-HSA-418885: DCC mediated attractive signaling R-HSA-1266738: Developmental Biology R-HSA-182971: EGFR downregulation R-HSA-2682334: EPH-Ephrin signaling R-HSA-3928662: EPHB-mediated forward signaling R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-416482: G alpha (12/13) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-114604: GPVI-mediated activation cascade R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-428543: Inactivation of Cdc42 and Rac R-HSA-168249: Innate Immune System R-HSA-5683057: MAPK family signaling cascades R-HSA-5687128: MAPK6/MAPK4 signaling R-HSA-525793: Myogenesis R-HSA-373752: Netrin-1 signaling R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-195258: RHO GTPase Effectors R-HSA-5663220: RHO GTPases Activate Formins R-HSA-5663213: RHO GTPases Activate WASPs and WAVEs R-HSA-5626467: RHO GTPases activate IQGAPs R-HSA-5625970: RHO GTPases activate KTN1 R-HSA-5627123: RHO GTPases activate PAKs R-HSA-2029482: Regulation of actin dynamics for phagocytic cup formation R-HSA-194840: Rho GTPase cycle R-HSA-400685: Sema4D in semaphorin signaling R-HSA-416572: Sema4D induced cell migration and growth-cone collapse R-HSA-373755: Semaphorin interactions R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-194315: Signaling by Rho GTPases R-HSA-376176: Signaling by Robo receptor R-HSA-194138: Signaling by VEGF R-HSA-4420097: VEGFA-VEGFR2 Pathway |
Summary | |
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Symbol | CDC42 |
Name | cell division cycle 42 |
Aliases | G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ...... |
Chromosomal Location | 1p36.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CDC42 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CDC42 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CDC42 |
Name | cell division cycle 42 |
Aliases | G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ...... |
Chromosomal Location | 1p36.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CDC42 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CDC42 |
Name | cell division cycle 42 |
Aliases | G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ...... |
Chromosomal Location | 1p36.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CDC42 in various data sets.
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Points in the above scatter plot represent the mutation difference of CDC42 in various data sets.
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Summary | |
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Symbol | CDC42 |
Name | cell division cycle 42 |
Aliases | G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ...... |
Chromosomal Location | 1p36.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDC42. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CDC42 |
Name | cell division cycle 42 |
Aliases | G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ...... |
Chromosomal Location | 1p36.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDC42. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDC42. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CDC42 |
Name | cell division cycle 42 |
Aliases | G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ...... |
Chromosomal Location | 1p36.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDC42. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CDC42 |
Name | cell division cycle 42 |
Aliases | G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ...... |
Chromosomal Location | 1p36.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CDC42 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CDC42 |
Name | cell division cycle 42 |
Aliases | G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ...... |
Chromosomal Location | 1p36.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CDC42 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CDC42 |
Name | cell division cycle 42 |
Aliases | G25K; CDC42Hs; GTP binding protein, 25kDa; cell division cycle 42 (GTP-binding protein, 25kD); cell division ...... |
Chromosomal Location | 1p36.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CDC42 collected from DrugBank database. |
Details on drugs targeting CDC42.
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