Summary | |
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Symbol | CDH1 |
Name | cadherin 1, type 1 |
Aliases | uvomorulin; CD324; E-Cadherin; UVO; cadherin 1, type 1, E-cadherin (epithelial); Arc-1; CDHE; ECAD; LCAM; CA ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell junction Cell membrane Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane. |
Domain |
PF00028 Cadherin domain PF01049 Cadherin cytoplasmic region PF08758 Cadherin prodomain like |
Function |
Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. ; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. |
Biological Process |
GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0007009 plasma membrane organization GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007162 negative regulation of cell adhesion GO:0007416 synapse assembly GO:0009636 response to toxic substance GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010226 response to lithium ion GO:0017038 protein import GO:0021536 diencephalon development GO:0021983 pituitary gland development GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0022617 extracellular matrix disassembly GO:0030198 extracellular matrix organization GO:0030900 forebrain development GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0033157 regulation of intracellular protein transport GO:0034330 cell junction organization GO:0034332 adherens junction organization GO:0034504 protein localization to nucleus GO:0035270 endocrine system development GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042493 response to drug GO:0042990 regulation of transcription factor import into nucleus GO:0042991 transcription factor import into nucleus GO:0042993 positive regulation of transcription factor import into nucleus GO:0043062 extracellular structure organization GO:0044744 protein targeting to nucleus GO:0045216 cell-cell junction organization GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0048732 gland development GO:0050808 synapse organization GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051222 positive regulation of protein transport GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071285 cellular response to lithium ion GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071680 response to indole-3-methanol GO:0071681 cellular response to indole-3-methanol GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090150 establishment of protein localization to membrane GO:0090316 positive regulation of intracellular protein transport GO:0097305 response to alcohol GO:0097306 cellular response to alcohol GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1902593 single-organism nuclear import GO:1903533 regulation of protein targeting GO:1903829 positive regulation of cellular protein localization GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904951 positive regulation of establishment of protein localization GO:1990778 protein localization to cell periphery |
Molecular Function |
GO:0001948 glycoprotein binding GO:0008013 beta-catenin binding GO:0030506 ankyrin binding GO:0032794 GTPase activating protein binding GO:0045295 gamma-catenin binding GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005802 trans-Golgi network GO:0005901 caveola GO:0005913 cell-cell adherens junction GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0005938 cell cortex GO:0009898 cytoplasmic side of plasma membrane GO:0015629 actin cytoskeleton GO:0016234 inclusion body GO:0016235 aggresome GO:0016328 lateral plasma membrane GO:0016342 catenin complex GO:0016600 flotillin complex GO:0019897 extrinsic component of plasma membrane GO:0019898 extrinsic component of membrane GO:0030027 lamellipodium GO:0030055 cell-substrate junction GO:0030863 cortical cytoskeleton GO:0030864 cortical actin cytoskeleton GO:0031252 cell leading edge GO:0031984 organelle subcompartment GO:0043296 apical junction complex GO:0044448 cell cortex part GO:0044853 plasma membrane raft GO:0045121 membrane raft GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane GO:0098589 membrane region GO:0098791 Golgi subcompartment GO:0098857 membrane microdomain GO:0099568 cytoplasmic region |
KEGG |
hsa04015 Rap1 signaling pathway hsa04390 Hippo signaling pathway hsa04514 Cell adhesion molecules (CAMs) hsa04520 Adherens junction |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-418990: Adherens junctions interactions R-HSA-109581: Apoptosis R-HSA-351906: Apoptotic cleavage of cell adhesion proteins R-HSA-111465: Apoptotic cleavage of cellular proteins R-HSA-75153: Apoptotic execution phase R-HSA-446728: Cell junction organization R-HSA-1500931: Cell-Cell communication R-HSA-421270: Cell-cell junction organization R-HSA-1474228: Degradation of the extracellular matrix R-HSA-1643685: Disease R-HSA-1474244: Extracellular matrix organization R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-5663205: Infectious disease R-HSA-8876493: InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-216083: Integrin cell surface interactions R-HSA-8876384: Listeria monocytogenes entry into host cells R-HSA-5357801: Programmed Cell Death R-HSA-195258: RHO GTPase Effectors R-HSA-5626467: RHO GTPases activate IQGAPs R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases |
Summary | |
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Symbol | CDH1 |
Name | cadherin 1, type 1 |
Aliases | uvomorulin; CD324; E-Cadherin; UVO; cadherin 1, type 1, E-cadherin (epithelial); Arc-1; CDHE; ECAD; LCAM; CA ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CDH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CDH1 |
Name | cadherin 1, type 1 |
Aliases | uvomorulin; CD324; E-Cadherin; UVO; cadherin 1, type 1, E-cadherin (epithelial); Arc-1; CDHE; ECAD; LCAM; CA ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CDH1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CDH1 |
Name | cadherin 1, type 1 |
Aliases | uvomorulin; CD324; E-Cadherin; UVO; cadherin 1, type 1, E-cadherin (epithelial); Arc-1; CDHE; ECAD; LCAM; CA ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CDH1 in various data sets.
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Points in the above scatter plot represent the mutation difference of CDH1 in various data sets.
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Summary | |
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Symbol | CDH1 |
Name | cadherin 1, type 1 |
Aliases | uvomorulin; CD324; E-Cadherin; UVO; cadherin 1, type 1, E-cadherin (epithelial); Arc-1; CDHE; ECAD; LCAM; CA ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CDH1 |
Name | cadherin 1, type 1 |
Aliases | uvomorulin; CD324; E-Cadherin; UVO; cadherin 1, type 1, E-cadherin (epithelial); Arc-1; CDHE; ECAD; LCAM; CA ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDH1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CDH1 |
Name | cadherin 1, type 1 |
Aliases | uvomorulin; CD324; E-Cadherin; UVO; cadherin 1, type 1, E-cadherin (epithelial); Arc-1; CDHE; ECAD; LCAM; CA ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CDH1 |
Name | cadherin 1, type 1 |
Aliases | uvomorulin; CD324; E-Cadherin; UVO; cadherin 1, type 1, E-cadherin (epithelial); Arc-1; CDHE; ECAD; LCAM; CA ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CDH1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CDH1 |
Name | cadherin 1, type 1 |
Aliases | uvomorulin; CD324; E-Cadherin; UVO; cadherin 1, type 1, E-cadherin (epithelial); Arc-1; CDHE; ECAD; LCAM; CA ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CDH1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CDH1 |
Name | cadherin 1, type 1 |
Aliases | uvomorulin; CD324; E-Cadherin; UVO; cadherin 1, type 1, E-cadherin (epithelial); Arc-1; CDHE; ECAD; LCAM; CA ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CDH1 collected from DrugBank database. |
There is no record. |