Summary | |
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Symbol | CDH17 |
Name | cadherin 17, LI cadherin (liver-intestine) |
Aliases | HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein |
Domain |
PF00028 Cadherin domain |
Function |
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. |
Biological Process |
GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002312 B cell activation involved in immune response GO:0002313 mature B cell differentiation involved in immune response GO:0002314 germinal center B cell differentiation GO:0002315 marginal zone B cell differentiation GO:0002335 mature B cell differentiation GO:0002366 leukocyte activation involved in immune response GO:0002521 leukocyte differentiation GO:0006857 oligopeptide transport GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007229 integrin-mediated signaling pathway GO:0015833 peptide transport GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0031334 positive regulation of protein complex assembly GO:0033622 integrin activation GO:0033623 regulation of integrin activation GO:0033625 positive regulation of integrin activation GO:0033626 positive regulation of integrin activation by cell surface receptor linked signal transduction GO:0034330 cell junction organization GO:0034332 adherens junction organization GO:0035672 oligopeptide transmembrane transport GO:0042113 B cell activation GO:0042886 amide transport GO:0043254 regulation of protein complex assembly GO:0044089 positive regulation of cellular component biogenesis GO:0045216 cell-cell junction organization GO:0048536 spleen development GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules |
Molecular Function |
GO:0005178 integrin binding GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity GO:0015197 peptide transporter activity GO:0015198 oligopeptide transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015322 secondary active oligopeptide transmembrane transporter activity GO:0022804 active transmembrane transporter activity GO:0035673 oligopeptide transmembrane transporter activity GO:0042887 amide transmembrane transporter activity GO:0050839 cell adhesion molecule binding GO:1904680 peptide transmembrane transporter activity |
Cellular Component |
GO:0016323 basolateral plasma membrane |
KEGG | - |
Reactome |
R-HSA-418990: Adherens junctions interactions R-HSA-446728: Cell junction organization R-HSA-1500931: Cell-Cell communication R-HSA-421270: Cell-cell junction organization |
Summary | |
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Symbol | CDH17 |
Name | cadherin 17, LI cadherin (liver-intestine) |
Aliases | HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CDH17 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CDH17 |
Name | cadherin 17, LI cadherin (liver-intestine) |
Aliases | HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CDH17 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CDH17 |
Name | cadherin 17, LI cadherin (liver-intestine) |
Aliases | HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CDH17 in various data sets.
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Points in the above scatter plot represent the mutation difference of CDH17 in various data sets.
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Summary | |
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Symbol | CDH17 |
Name | cadherin 17, LI cadherin (liver-intestine) |
Aliases | HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDH17. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CDH17 |
Name | cadherin 17, LI cadherin (liver-intestine) |
Aliases | HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDH17. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDH17. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CDH17 |
Name | cadherin 17, LI cadherin (liver-intestine) |
Aliases | HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDH17. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CDH17 |
Name | cadherin 17, LI cadherin (liver-intestine) |
Aliases | HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CDH17 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CDH17 |
Name | cadherin 17, LI cadherin (liver-intestine) |
Aliases | HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CDH17 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CDH17 |
Name | cadherin 17, LI cadherin (liver-intestine) |
Aliases | HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CDH17 collected from DrugBank database. |
There is no record. |