Browse CDH17

Summary
SymbolCDH17
Namecadherin 17, LI cadherin (liver-intestine)
Aliases HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location8q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass type I membrane protein
Domain PF00028 Cadherin domain
Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.

> Gene Ontology
 
Biological Process GO:0002263 cell activation involved in immune response
GO:0002285 lymphocyte activation involved in immune response
GO:0002312 B cell activation involved in immune response
GO:0002313 mature B cell differentiation involved in immune response
GO:0002314 germinal center B cell differentiation
GO:0002315 marginal zone B cell differentiation
GO:0002335 mature B cell differentiation
GO:0002366 leukocyte activation involved in immune response
GO:0002521 leukocyte differentiation
GO:0006857 oligopeptide transport
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007229 integrin-mediated signaling pathway
GO:0015833 peptide transport
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0030098 lymphocyte differentiation
GO:0030183 B cell differentiation
GO:0031334 positive regulation of protein complex assembly
GO:0033622 integrin activation
GO:0033623 regulation of integrin activation
GO:0033625 positive regulation of integrin activation
GO:0033626 positive regulation of integrin activation by cell surface receptor linked signal transduction
GO:0034330 cell junction organization
GO:0034332 adherens junction organization
GO:0035672 oligopeptide transmembrane transport
GO:0042113 B cell activation
GO:0042886 amide transport
GO:0043254 regulation of protein complex assembly
GO:0044089 positive regulation of cellular component biogenesis
GO:0045216 cell-cell junction organization
GO:0048536 spleen development
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
Molecular Function GO:0005178 integrin binding
GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity
GO:0015197 peptide transporter activity
GO:0015198 oligopeptide transporter activity
GO:0015291 secondary active transmembrane transporter activity
GO:0015322 secondary active oligopeptide transmembrane transporter activity
GO:0022804 active transmembrane transporter activity
GO:0035673 oligopeptide transmembrane transporter activity
GO:0042887 amide transmembrane transporter activity
GO:0050839 cell adhesion molecule binding
GO:1904680 peptide transmembrane transporter activity
Cellular Component GO:0016323 basolateral plasma membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-418990: Adherens junctions interactions
R-HSA-446728: Cell junction organization
R-HSA-1500931: Cell-Cell communication
R-HSA-421270: Cell-cell junction organization
Summary
SymbolCDH17
Namecadherin 17, LI cadherin (liver-intestine)
Aliases HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location8q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CDH17 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCDH17
Namecadherin 17, LI cadherin (liver-intestine)
Aliases HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location8q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CDH17 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCDH17
Namecadherin 17, LI cadherin (liver-intestine)
Aliases HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location8q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CDH17 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.940.0625
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.720.539
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.2160.397
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.110.872
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3790.744
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4390.761
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3130.585
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.270.708
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.8250.0109
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CDH17 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.12.78.40.12
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.13.47.70.176
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.817.6-12.80.307
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.516.7-4.21
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)1311018.2-18.20.199
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCDH17
Namecadherin 17, LI cadherin (liver-intestine)
Aliases HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location8q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDH17. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCDH17
Namecadherin 17, LI cadherin (liver-intestine)
Aliases HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location8q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDH17. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDH17.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCDH17
Namecadherin 17, LI cadherin (liver-intestine)
Aliases HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location8q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDH17. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCDH17
Namecadherin 17, LI cadherin (liver-intestine)
Aliases HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location8q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CDH17 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCDH17
Namecadherin 17, LI cadherin (liver-intestine)
Aliases HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location8q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CDH17 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCDH17
Namecadherin 17, LI cadherin (liver-intestine)
Aliases HPT-1; cadherin; HPT1; HPT-1 cadherin; LI cadherin; LI-cadherin; human intestinal peptide-associated transpo ......
Chromosomal Location8q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CDH17 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.