Summary | |
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Symbol | CDH2 |
Name | cadherin 2, type 1, N-cadherin (neuronal) |
Aliases | CDHN; CD325; N-cadherin; NCAD; CDw325; N-cadherin 1; calcium-dependent adhesion protein, neuronal; neural ca ...... |
Chromosomal Location | 18q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Cell membrane, sarcolemma Cell junction Cell surface Note=Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes. |
Domain |
PF00028 Cadherin domain PF01049 Cadherin cytoplasmic region PF08758 Cadherin prodomain like |
Function |
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity). |
Biological Process |
GO:0001941 postsynaptic membrane organization GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0007009 plasma membrane organization GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007416 synapse assembly GO:0010001 glial cell differentiation GO:0014013 regulation of gliogenesis GO:0016055 Wnt signaling pathway GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0019827 stem cell population maintenance GO:0021537 telencephalon development GO:0021543 pallium development GO:0021987 cerebral cortex development GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030900 forebrain development GO:0034330 cell junction organization GO:0034332 adherens junction organization GO:0042063 gliogenesis GO:0042692 muscle cell differentiation GO:0043113 receptor clustering GO:0043410 positive regulation of MAPK cascade GO:0044091 membrane biogenesis GO:0044331 cell-cell adhesion mediated by cadherin GO:0045216 cell-cell junction organization GO:0048514 blood vessel morphogenesis GO:0048854 brain morphogenesis GO:0048872 homeostasis of number of cells GO:0050803 regulation of synapse structure or activity GO:0050807 regulation of synapse organization GO:0050808 synapse organization GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051149 positive regulation of muscle cell differentiation GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051668 localization within membrane GO:0060019 radial glial cell differentiation GO:0060070 canonical Wnt signaling pathway GO:0060563 neuroepithelial cell differentiation GO:0060828 regulation of canonical Wnt signaling pathway GO:0061351 neural precursor cell proliferation GO:0070444 oligodendrocyte progenitor proliferation GO:0070445 regulation of oligodendrocyte progenitor proliferation GO:0071709 membrane assembly GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090150 establishment of protein localization to membrane GO:0097091 synaptic vesicle clustering GO:0097104 postsynaptic membrane assembly GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly GO:0097119 postsynaptic density protein 95 clustering GO:0097150 neuronal stem cell population maintenance GO:0097479 synaptic vesicle localization GO:0098727 maintenance of cell number GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:0099068 postsynapse assembly GO:0099504 synaptic vesicle cycle GO:0198738 cell-cell signaling by wnt GO:1901626 regulation of postsynaptic membrane organization GO:1902897 regulation of postsynaptic density protein 95 clustering GO:1990778 protein localization to cell periphery GO:2000177 regulation of neural precursor cell proliferation GO:2000807 regulation of synaptic vesicle clustering GO:2000809 positive regulation of synaptic vesicle clustering |
Molecular Function |
GO:0008013 beta-catenin binding GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0045294 alpha-catenin binding GO:0045295 gamma-catenin binding |
Cellular Component |
GO:0005913 cell-cell adherens junction GO:0005916 fascia adherens GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0005938 cell cortex GO:0014704 intercalated disc GO:0015629 actin cytoskeleton GO:0016323 basolateral plasma membrane GO:0016324 apical plasma membrane GO:0016342 catenin complex GO:0019897 extrinsic component of plasma membrane GO:0019898 extrinsic component of membrane GO:0030027 lamellipodium GO:0030055 cell-substrate junction GO:0030863 cortical cytoskeleton GO:0030864 cortical actin cytoskeleton GO:0031252 cell leading edge GO:0044291 cell-cell contact zone GO:0044448 cell cortex part GO:0044853 plasma membrane raft GO:0045121 membrane raft GO:0045177 apical part of cell GO:0098589 membrane region GO:0098857 membrane microdomain GO:0099568 cytoplasmic region |
KEGG |
hsa04514 Cell adhesion molecules (CAMs) |
Reactome |
R-HSA-418990: Adherens junctions interactions R-HSA-375170: CDO in myogenesis R-HSA-446728: Cell junction organization R-HSA-1500931: Cell-Cell communication R-HSA-421270: Cell-cell junction organization R-HSA-1266738: Developmental Biology R-HSA-525793: Myogenesis |
Summary | |
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Symbol | CDH2 |
Name | cadherin 2, type 1, N-cadherin (neuronal) |
Aliases | CDHN; CD325; N-cadherin; NCAD; CDw325; N-cadherin 1; calcium-dependent adhesion protein, neuronal; neural ca ...... |
Chromosomal Location | 18q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CDH2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CDH2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CDH2 |
Name | cadherin 2, type 1, N-cadherin (neuronal) |
Aliases | CDHN; CD325; N-cadherin; NCAD; CDw325; N-cadherin 1; calcium-dependent adhesion protein, neuronal; neural ca ...... |
Chromosomal Location | 18q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CDH2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CDH2 |
Name | cadherin 2, type 1, N-cadherin (neuronal) |
Aliases | CDHN; CD325; N-cadherin; NCAD; CDw325; N-cadherin 1; calcium-dependent adhesion protein, neuronal; neural ca ...... |
Chromosomal Location | 18q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CDH2 in various data sets.
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Points in the above scatter plot represent the mutation difference of CDH2 in various data sets.
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Summary | |
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Symbol | CDH2 |
Name | cadherin 2, type 1, N-cadherin (neuronal) |
Aliases | CDHN; CD325; N-cadherin; NCAD; CDw325; N-cadherin 1; calcium-dependent adhesion protein, neuronal; neural ca ...... |
Chromosomal Location | 18q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDH2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CDH2 |
Name | cadherin 2, type 1, N-cadherin (neuronal) |
Aliases | CDHN; CD325; N-cadherin; NCAD; CDw325; N-cadherin 1; calcium-dependent adhesion protein, neuronal; neural ca ...... |
Chromosomal Location | 18q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDH2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDH2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CDH2 |
Name | cadherin 2, type 1, N-cadherin (neuronal) |
Aliases | CDHN; CD325; N-cadherin; NCAD; CDw325; N-cadherin 1; calcium-dependent adhesion protein, neuronal; neural ca ...... |
Chromosomal Location | 18q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDH2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CDH2 |
Name | cadherin 2, type 1, N-cadherin (neuronal) |
Aliases | CDHN; CD325; N-cadherin; NCAD; CDw325; N-cadherin 1; calcium-dependent adhesion protein, neuronal; neural ca ...... |
Chromosomal Location | 18q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CDH2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CDH2 |
Name | cadherin 2, type 1, N-cadherin (neuronal) |
Aliases | CDHN; CD325; N-cadherin; NCAD; CDw325; N-cadherin 1; calcium-dependent adhesion protein, neuronal; neural ca ...... |
Chromosomal Location | 18q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CDH2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CDH2 |
Name | cadherin 2, type 1, N-cadherin (neuronal) |
Aliases | CDHN; CD325; N-cadherin; NCAD; CDw325; N-cadherin 1; calcium-dependent adhesion protein, neuronal; neural ca ...... |
Chromosomal Location | 18q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CDH2 collected from DrugBank database. |
There is no record. |