Browse CDK1

Summary
SymbolCDK1
Namecyclin-dependent kinase 1
Aliases CDC28A; cell division cycle 2, G1 to S and G2 to M; P34CDC2; cell cycle controller CDC2; cell division contr ......
Chromosomal Location10q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.
Domain PF00069 Protein kinase domain
Function

Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration. CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). ; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry.

> Gene Ontology
 
Biological Process GO:0000060 protein import into nucleus, translocation
GO:0000075 cell cycle checkpoint
GO:0000077 DNA damage checkpoint
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000187 activation of MAPK activity
GO:0000226 microtubule cytoskeleton organization
GO:0000302 response to reactive oxygen species
GO:0000741 karyogamy
GO:0006260 DNA replication
GO:0006275 regulation of DNA replication
GO:0006323 DNA packaging
GO:0006606 protein import into nucleus
GO:0006913 nucleocytoplasmic transport
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006979 response to oxidative stress
GO:0006997 nucleus organization
GO:0006998 nuclear envelope organization
GO:0007030 Golgi organization
GO:0007050 cell cycle arrest
GO:0007067 mitotic nuclear division
GO:0007077 mitotic nuclear envelope disassembly
GO:0007093 mitotic cell cycle checkpoint
GO:0007095 mitotic G2 DNA damage checkpoint
GO:0007098 centrosome cycle
GO:0007338 single fertilization
GO:0007344 pronuclear fusion
GO:0007346 regulation of mitotic cell cycle
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007568 aging
GO:0007569 cell aging
GO:0009566 fertilization
GO:0009636 response to toxic substance
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0010001 glial cell differentiation
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010498 proteasomal protein catabolic process
GO:0010948 negative regulation of cell cycle process
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0014013 regulation of gliogenesis
GO:0014037 Schwann cell differentiation
GO:0014038 regulation of Schwann cell differentiation
GO:0014075 response to amine
GO:0014706 striated muscle tissue development
GO:0014823 response to activity
GO:0014855 striated muscle cell proliferation
GO:0016202 regulation of striated muscle tissue development
GO:0016570 histone modification
GO:0016572 histone phosphorylation
GO:0017038 protein import
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018210 peptidyl-threonine modification
GO:0030261 chromosome condensation
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0030397 membrane disassembly
GO:0031023 microtubule organizing center organization
GO:0031099 regeneration
GO:0031100 animal organ regeneration
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031396 regulation of protein ubiquitination
GO:0031397 negative regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0031570 DNA integrity checkpoint
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0031572 G2 DNA damage checkpoint
GO:0032147 activation of protein kinase activity
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0033002 muscle cell proliferation
GO:0033157 regulation of intracellular protein transport
GO:0033158 regulation of protein import into nucleus, translocation
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0033674 positive regulation of kinase activity
GO:0034501 protein localization to kinetochore
GO:0034502 protein localization to chromosome
GO:0034504 protein localization to nucleus
GO:0034599 cellular response to oxidative stress
GO:0034614 cellular response to reactive oxygen species
GO:0035051 cardiocyte differentiation
GO:0035265 organ growth
GO:0042063 gliogenesis
GO:0042176 regulation of protein catabolic process
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042692 muscle cell differentiation
GO:0042770 signal transduction in response to DNA damage
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0044744 protein targeting to nucleus
GO:0044770 cell cycle phase transition
GO:0044772 mitotic cell cycle phase transition
GO:0044773 mitotic DNA damage checkpoint
GO:0044774 mitotic DNA integrity checkpoint
GO:0044783 G1 DNA damage checkpoint
GO:0044818 mitotic G2/M transition checkpoint
GO:0044819 mitotic G1/S transition checkpoint
GO:0044839 cell cycle G2/M phase transition
GO:0044843 cell cycle G1/S phase transition
GO:0045471 response to ethanol
GO:0045685 regulation of glial cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045740 positive regulation of DNA replication
GO:0045786 negative regulation of cell cycle
GO:0045787 positive regulation of cell cycle
GO:0045844 positive regulation of striated muscle tissue development
GO:0045860 positive regulation of protein kinase activity
GO:0045862 positive regulation of proteolysis
GO:0045927 positive regulation of growth
GO:0045930 negative regulation of mitotic cell cycle
GO:0045931 positive regulation of mitotic cell cycle
GO:0045995 regulation of embryonic development
GO:0046620 regulation of organ growth
GO:0046622 positive regulation of organ growth
GO:0046686 response to cadmium ion
GO:0046688 response to copper ion
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0048284 organelle fusion
GO:0048308 organelle inheritance
GO:0048313 Golgi inheritance
GO:0048634 regulation of muscle organ development
GO:0048636 positive regulation of muscle organ development
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048678 response to axon injury
GO:0048738 cardiac muscle tissue development
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0051081 nuclear envelope disassembly
GO:0051146 striated muscle cell differentiation
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051222 positive regulation of protein transport
GO:0051297 centrosome organization
GO:0051348 negative regulation of transferase activity
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0051438 regulation of ubiquitin-protein transferase activity
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0055001 muscle cell development
GO:0055002 striated muscle cell development
GO:0055006 cardiac cell development
GO:0055007 cardiac muscle cell differentiation
GO:0055012 ventricular cardiac muscle cell differentiation
GO:0055013 cardiac muscle cell development
GO:0055015 ventricular cardiac muscle cell development
GO:0055017 cardiac muscle tissue growth
GO:0055021 regulation of cardiac muscle tissue growth
GO:0055023 positive regulation of cardiac muscle tissue growth
GO:0055024 regulation of cardiac muscle tissue development
GO:0055025 positive regulation of cardiac muscle tissue development
GO:0060038 cardiac muscle cell proliferation
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060419 heart growth
GO:0060420 regulation of heart growth
GO:0060421 positive regulation of heart growth
GO:0060537 muscle tissue development
GO:0070301 cellular response to hydrogen peroxide
GO:0071103 DNA conformation change
GO:0071156 regulation of cell cycle arrest
GO:0071158 positive regulation of cell cycle arrest
GO:0071459 protein localization to chromosome, centromeric region
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072331 signal transduction by p53 class mediator
GO:0072395 signal transduction involved in cell cycle checkpoint
GO:0072401 signal transduction involved in DNA integrity checkpoint
GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
GO:0072422 signal transduction involved in DNA damage checkpoint
GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint
GO:0090068 positive regulation of cell cycle process
GO:0090166 Golgi disassembly
GO:0090316 positive regulation of intracellular protein transport
GO:0097305 response to alcohol
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1901861 regulation of muscle tissue development
GO:1901863 positive regulation of muscle tissue development
GO:1901987 regulation of cell cycle phase transition
GO:1901988 negative regulation of cell cycle phase transition
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1901991 negative regulation of mitotic cell cycle phase transition
GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint
GO:1902402 signal transduction involved in mitotic DNA damage checkpoint
GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint
GO:1902593 single-organism nuclear import
GO:1902749 regulation of cell cycle G2/M phase transition
GO:1902750 negative regulation of cell cycle G2/M phase transition
GO:1902806 regulation of cell cycle G1/S phase transition
GO:1902807 negative regulation of cell cycle G1/S phase transition
GO:1903008 organelle disassembly
GO:1903050 regulation of proteolysis involved in cellular protein catabolic process
GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process
GO:1903320 regulation of protein modification by small protein conjugation or removal
GO:1903321 negative regulation of protein modification by small protein conjugation or removal
GO:1903322 positive regulation of protein modification by small protein conjugation or removal
GO:1903362 regulation of cellular protein catabolic process
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903533 regulation of protein targeting
GO:1903829 positive regulation of cellular protein localization
GO:1904589 regulation of protein import
GO:1904591 positive regulation of protein import
GO:1904666 regulation of ubiquitin protein ligase activity
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:1904668 positive regulation of ubiquitin protein ligase activity
GO:1904951 positive regulation of establishment of protein localization
GO:1990267 response to transition metal nanoparticle
GO:2000045 regulation of G1/S transition of mitotic cell cycle
GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Molecular Function GO:0003682 chromatin binding
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0030332 cyclin binding
GO:0030544 Hsp70 protein binding
GO:0031072 heat shock protein binding
GO:0035173 histone kinase activity
GO:0097472 cyclin-dependent protein kinase activity
Cellular Component GO:0000781 chromosome, telomeric region
GO:0000784 nuclear chromosome, telomeric region
GO:0005813 centrosome
GO:0005819 spindle
GO:0005874 microtubule
GO:0005876 spindle microtubule
GO:0030496 midbody
GO:0044454 nuclear chromosome part
GO:0072686 mitotic spindle
GO:0098687 chromosomal region
> KEGG and Reactome Pathway
 
KEGG hsa04110 Cell cycle
hsa04114 Oocyte meiosis
hsa04115 p53 signaling pathway
hsa04540 Gap junction
hsa04914 Progesterone-mediated oocyte maturation
Reactome R-HSA-174143: APC/C-mediated degradation of cell cycle proteins
R-HSA-174048: APC/C
R-HSA-176409: APC/C
R-HSA-179419: APC
R-HSA-8854518: AURKA Activation by TPX2
R-HSA-176814: Activation of APC/C and APC/C
R-HSA-2980767: Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-5620912: Anchoring of the basal body to the plasma membrane
R-HSA-174184: Cdc20
R-HSA-1640170: Cell Cycle
R-HSA-69620: Cell Cycle Checkpoints
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-380287: Centrosome maturation
R-HSA-75035: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B
R-HSA-5617833: Cilium Assembly
R-HSA-2514853: Condensation of Prometaphase Chromosomes
R-HSA-2299718: Condensation of Prophase Chromosomes
R-HSA-69273: Cyclin A/B1 associated events during G2/M transition
R-HSA-157881: Cyclin B2 mediated events
R-HSA-4419969: Depolymerisation of the Nuclear Lamina
R-HSA-113510: E2F mediated regulation of DNA replication
R-HSA-113507: E2F-enabled inhibition of pre-replication complex formation
R-HSA-1538133: G0 and Early G1
R-HSA-69206: G1/S Transition
R-HSA-69205: G1/S-Specific Transcription
R-HSA-69481: G2/M Checkpoints
R-HSA-69473: G2/M DNA damage checkpoint
R-HSA-69478: G2/M DNA replication checkpoint
R-HSA-69275: G2/M Transition
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-162658: Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-380259: Loss of Nlp from mitotic centrosomes
R-HSA-380284: Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-68886: M Phase
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-110056: MAPK3 (ERK1) activation
R-HSA-5687128: MAPK6/MAPK4 signaling
R-HSA-2465910: MASTL Facilitates Mitotic Progression
R-HSA-453279: Mitotic G1-G1/S phases
R-HSA-453274: Mitotic G2-G2/M phases
R-HSA-68877: Mitotic Prometaphase
R-HSA-68875: Mitotic Prophase
R-HSA-2980766: Nuclear Envelope Breakdown
R-HSA-3301854: Nuclear Pore Complex (NPC) Disassembly
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-176417: Phosphorylation of Emi1
R-HSA-170145: Phosphorylation of proteins involved in the G2/M transition by Cyclin A
R-HSA-176412: Phosphorylation of the APC/C
R-HSA-112409: RAF-independent MAPK1/3 activation
R-HSA-380320: Recruitment of NuMA to mitotic centrosomes
R-HSA-380270: Recruitment of mitotic centrosome proteins and complexes
R-HSA-176408: Regulation of APC/C activators between G1/S and early anaphase
R-HSA-2565942: Regulation of PLK1 Activity at G2/M Transition
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804757: Regulation of TP53 Degradation
R-HSA-6806003: Regulation of TP53 Expression and Degradation
R-HSA-453276: Regulation of mitotic cell cycle
R-HSA-2500257: Resolution of Sister Chromatid Cohesion
R-HSA-162582: Signal Transduction
R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes
R-HSA-6804114: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-8852276: The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-3700989: Transcriptional Regulation by TP53
Summary
SymbolCDK1
Namecyclin-dependent kinase 1
Aliases CDC28A; cell division cycle 2, G1 to S and G2 to M; P34CDC2; cell cycle controller CDC2; cell division contr ......
Chromosomal Location10q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CDK1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CDK1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
25016158Breast carcinomaInhibit immunityMoreover, systemic delivery of NPsiCDK1 is able to suppress tumor growth in mice bearing SUM149 and BT549 xenograft and cause no systemic toxicity or activate the innate immune response, suggesting the therapeutic promise with such nanoparticles carrying siCDK1 for c-Myc overexpressed triple negative breast cancer.
Summary
SymbolCDK1
Namecyclin-dependent kinase 1
Aliases CDC28A; cell division cycle 2, G1 to S and G2 to M; P34CDC2; cell cycle controller CDC2; cell division contr ......
Chromosomal Location10q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CDK1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCDK1
Namecyclin-dependent kinase 1
Aliases CDC28A; cell division cycle 2, G1 to S and G2 to M; P34CDC2; cell cycle controller CDC2; cell division contr ......
Chromosomal Location10q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CDK1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1870.563
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1810.93
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1960.902
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2930.535
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.170.883
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.4440.763
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.320.456
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.6230.701
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1480.928
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.5970.632
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.4670.803
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.470.000578
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CDK1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCDK1
Namecyclin-dependent kinase 1
Aliases CDC28A; cell division cycle 2, G1 to S and G2 to M; P34CDC2; cell cycle controller CDC2; cell division contr ......
Chromosomal Location10q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDK1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCDK1
Namecyclin-dependent kinase 1
Aliases CDC28A; cell division cycle 2, G1 to S and G2 to M; P34CDC2; cell cycle controller CDC2; cell division contr ......
Chromosomal Location10q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDK1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDK1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCDK1
Namecyclin-dependent kinase 1
Aliases CDC28A; cell division cycle 2, G1 to S and G2 to M; P34CDC2; cell cycle controller CDC2; cell division contr ......
Chromosomal Location10q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDK1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCDK1
Namecyclin-dependent kinase 1
Aliases CDC28A; cell division cycle 2, G1 to S and G2 to M; P34CDC2; cell cycle controller CDC2; cell division contr ......
Chromosomal Location10q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CDK1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCDK1
Namecyclin-dependent kinase 1
Aliases CDC28A; cell division cycle 2, G1 to S and G2 to M; P34CDC2; cell cycle controller CDC2; cell division contr ......
Chromosomal Location10q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CDK1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCDK1
Namecyclin-dependent kinase 1
Aliases CDC28A; cell division cycle 2, G1 to S and G2 to M; P34CDC2; cell cycle controller CDC2; cell division contr ......
Chromosomal Location10q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CDK1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CDK1.
ID Name Drug Type Targets #Targets
DB02052Indirubin-3'-MonoximeSmall MoleculeAHR, CDK1, CDK2, CDK5, CDK5R1, GSK3B6
DB02116OlomoucineSmall MoleculeCDK1, CDK2, CDK5, MAPK14
DB02950HymenialdisineSmall MoleculeCDK1, CDK2, CDK53
DB03428SU9516Small MoleculeCDK1, CDK2, CDK53
DB03496AlvocidibSmall MoleculeCDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, EGFR, PYGB, PYGL, ......12
DB04014AlsterpaulloneSmall MoleculeCDK1, CDK5, GSK3B3
DB05037AT7519Small MoleculeCDK1, CDK22
DB06195SeliciclibSmall MoleculeCDK1, CDK2, CDK7, CDK9, CSNK1E, MAPK1, MAPK37