Summary | |
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Symbol | CDK2 |
Name | cyclin-dependent kinase 2 |
Aliases | p33(CDK2); cell division protein kinase 2; p33 protein kinase |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Note=Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3). |
Domain |
PF00069 Protein kinase domain |
Function |
Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 (PubMed:12944431). |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000082 G1/S transition of mitotic cell cycle GO:0000086 G2/M transition of mitotic cell cycle GO:0000226 microtubule cytoskeleton organization GO:0000302 response to reactive oxygen species GO:0006260 DNA replication GO:0006261 DNA-dependent DNA replication GO:0006270 DNA replication initiation GO:0006275 regulation of DNA replication GO:0006813 potassium ion transport GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006979 response to oxidative stress GO:0007050 cell cycle arrest GO:0007067 mitotic nuclear division GO:0007093 mitotic cell cycle checkpoint GO:0007098 centrosome cycle GO:0007099 centriole replication GO:0007126 meiotic nuclear division GO:0007265 Ras protein signal transduction GO:0007346 regulation of mitotic cell cycle GO:0010035 response to inorganic substance GO:0010948 negative regulation of cell cycle process GO:0015672 monovalent inorganic cation transport GO:0016458 gene silencing GO:0016570 histone modification GO:0016572 histone phosphorylation GO:0018105 peptidyl-serine phosphorylation GO:0018209 peptidyl-serine modification GO:0030174 regulation of DNA-dependent DNA replication initiation GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0031023 microtubule organizing center organization GO:0031396 regulation of protein ubiquitination GO:0031397 negative regulation of protein ubiquitination GO:0031570 DNA integrity checkpoint GO:0031571 mitotic G1 DNA damage checkpoint GO:0032298 positive regulation of DNA-dependent DNA replication initiation GO:0034599 cellular response to oxidative stress GO:0034614 cellular response to reactive oxygen species GO:0042770 signal transduction in response to DNA damage GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044783 G1 DNA damage checkpoint GO:0044819 mitotic G1/S transition checkpoint GO:0044839 cell cycle G2/M phase transition GO:0044843 cell cycle G1/S phase transition GO:0045740 positive regulation of DNA replication GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045930 negative regulation of mitotic cell cycle GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051297 centrosome organization GO:0051298 centrosome duplication GO:0051321 meiotic cell cycle GO:0051348 negative regulation of transferase activity GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051438 regulation of ubiquitin-protein transferase activity GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051444 negative regulation of ubiquitin-protein transferase activity GO:0060968 regulation of gene silencing GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0071241 cellular response to inorganic substance GO:0071731 response to nitric oxide GO:0071732 cellular response to nitric oxide GO:0072331 signal transduction by p53 class mediator GO:0072395 signal transduction involved in cell cycle checkpoint GO:0072401 signal transduction involved in DNA integrity checkpoint GO:0072413 signal transduction involved in mitotic cell cycle checkpoint GO:0072422 signal transduction involved in DNA damage checkpoint GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint GO:0090068 positive regulation of cell cycle process GO:0090329 regulation of DNA-dependent DNA replication GO:0098534 centriole assembly GO:1901796 regulation of signal transduction by p53 class mediator GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902170 cellular response to reactive nitrogen species GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint GO:1902402 signal transduction involved in mitotic DNA damage checkpoint GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:1903046 meiotic cell cycle process GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903321 negative regulation of protein modification by small protein conjugation or removal GO:1904666 regulation of ubiquitin protein ligase activity GO:1904667 negative regulation of ubiquitin protein ligase activity GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000105 positive regulation of DNA-dependent DNA replication GO:2000134 negative regulation of G1/S transition of mitotic cell cycle |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0030332 cyclin binding GO:0035173 histone kinase activity GO:0097472 cyclin-dependent protein kinase activity |
Cellular Component |
GO:0000307 cyclin-dependent protein kinase holoenzyme complex GO:0000781 chromosome, telomeric region GO:0000793 condensed chromosome GO:0000803 sex chromosome GO:0000805 X chromosome GO:0000806 Y chromosome GO:0005667 transcription factor complex GO:0005813 centrosome GO:0015030 Cajal body GO:0016604 nuclear body GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0098687 chromosomal region GO:1902554 serine/threonine protein kinase complex GO:1902911 protein kinase complex |
KEGG |
hsa04068 FoxO signaling pathway hsa04110 Cell cycle hsa04114 Oocyte meiosis hsa04115 p53 signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04914 Progesterone-mediated oocyte maturation |
Reactome |
R-HSA-174143: APC/C-mediated degradation of cell cycle proteins R-HSA-176187: Activation of ATR in response to replication stress R-HSA-68962: Activation of the pre-replicative complex R-HSA-69017: CDK-mediated phosphorylation and removal of Cdc6 R-HSA-1640170: Cell Cycle R-HSA-69620: Cell Cycle Checkpoints R-HSA-69278: Cell Cycle, Mitotic R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-69273: Cyclin A/B1 associated events during G2/M transition R-HSA-69656: Cyclin A R-HSA-69202: Cyclin E associated events during G1/S transition R-HSA-2559586: DNA Damage/Telomere Stress Induced Senescence R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-69306: DNA Replication R-HSA-69002: DNA Replication Pre-Initiation R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-1538133: G0 and Early G1 R-HSA-69615: G1/S DNA Damage Checkpoints R-HSA-69206: G1/S Transition R-HSA-68911: G2 Phase R-HSA-69481: G2/M Checkpoints R-HSA-69275: G2/M Transition R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-5693567: HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) R-HSA-109582: Hemostasis R-HSA-5693538: Homology Directed Repair R-HSA-68874: M/G1 Transition R-HSA-1500620: Meiosis R-HSA-912446: Meiotic recombination R-HSA-453279: Mitotic G1-G1/S phases R-HSA-453274: Mitotic G2-G2/M phases R-HSA-68949: Orc1 removal from chromatin R-HSA-8849470: PTK6 Regulates Cell Cycle R-HSA-69200: Phosphorylation of proteins involved in G1/S transition by active Cyclin E R-HSA-5693607: Processing of DNA double-strand break ends R-HSA-176408: Regulation of APC/C activators between G1/S and early anaphase R-HSA-69304: Regulation of DNA replication R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation R-HSA-6804757: Regulation of TP53 Degradation R-HSA-6806003: Regulation of TP53 Expression and Degradation R-HSA-453276: Regulation of mitotic cell cycle R-HSA-69300: Removal of licensing factors from origins R-HSA-69242: S Phase R-HSA-187577: SCF(Skp2)-mediated degradation of p27/p21 R-HSA-2559582: Senescence-Associated Secretory Phenotype (SASP) R-HSA-162582: Signal Transduction R-HSA-8848021: Signaling by PTK6 R-HSA-69052: Switching of origins to a post-replicative state R-HSA-69239: Synthesis of DNA R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6804116: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-69563: p53-Dependent G1 DNA Damage Response R-HSA-69580: p53-Dependent G1/S DNA damage checkpoint |
Summary | |
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Symbol | CDK2 |
Name | cyclin-dependent kinase 2 |
Aliases | p33(CDK2); cell division protein kinase 2; p33 protein kinase |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CDK2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | CDK2 |
Name | cyclin-dependent kinase 2 |
Aliases | p33(CDK2); cell division protein kinase 2; p33 protein kinase |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CDK2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CDK2 |
Name | cyclin-dependent kinase 2 |
Aliases | p33(CDK2); cell division protein kinase 2; p33 protein kinase |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CDK2 in various data sets.
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Points in the above scatter plot represent the mutation difference of CDK2 in various data sets.
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Summary | |
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Symbol | CDK2 |
Name | cyclin-dependent kinase 2 |
Aliases | p33(CDK2); cell division protein kinase 2; p33 protein kinase |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDK2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CDK2 |
Name | cyclin-dependent kinase 2 |
Aliases | p33(CDK2); cell division protein kinase 2; p33 protein kinase |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDK2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDK2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CDK2 |
Name | cyclin-dependent kinase 2 |
Aliases | p33(CDK2); cell division protein kinase 2; p33 protein kinase |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDK2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CDK2 |
Name | cyclin-dependent kinase 2 |
Aliases | p33(CDK2); cell division protein kinase 2; p33 protein kinase |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CDK2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CDK2 |
Name | cyclin-dependent kinase 2 |
Aliases | p33(CDK2); cell division protein kinase 2; p33 protein kinase |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CDK2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CDK2 |
Name | cyclin-dependent kinase 2 |
Aliases | p33(CDK2); cell division protein kinase 2; p33 protein kinase |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CDK2 collected from DrugBank database. |
Details on drugs targeting CDK2.
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