Summary | |
---|---|
Symbol | CDK5R1 |
Name | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
Aliases | p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cyclin-dependent kinase 5 activator 1, p35: Cell membrane Lipid-anchor Cytoplasmic side Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.; SUBCELLULAR LOCATION: Cyclin-dependent kinase 5 activator 1, p25: Nucleus. Cytoplasm, perinuclear region. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites. |
Domain |
PF03261 Cyclin-dependent kinase 5 activator protein |
Function |
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. |
Biological Process |
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000226 microtubule cytoskeleton organization GO:0001558 regulation of cell growth GO:0001764 neuron migration GO:0006612 protein targeting to membrane GO:0006914 autophagy GO:0007050 cell cycle arrest GO:0007158 neuron cell-cell adhesion GO:0007213 G-protein coupled acetylcholine receptor signaling pathway GO:0007215 glutamate receptor signaling pathway GO:0007409 axonogenesis GO:0007411 axon guidance GO:0007413 axonal fasciculation GO:0008037 cell recognition GO:0008038 neuron recognition GO:0008347 glial cell migration GO:0008361 regulation of cell size GO:0010506 regulation of autophagy GO:0010721 negative regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010771 negative regulation of cell morphogenesis involved in differentiation GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0016049 cell growth GO:0016236 macroautophagy GO:0016241 regulation of macroautophagy GO:0016358 dendrite development GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018209 peptidyl-serine modification GO:0018210 peptidyl-threonine modification GO:0021537 telencephalon development GO:0021543 pallium development GO:0021548 pons development GO:0021549 cerebellum development GO:0021578 hindbrain maturation GO:0021586 pons maturation GO:0021626 central nervous system maturation GO:0021700 developmental maturation GO:0021718 superior olivary nucleus development GO:0021722 superior olivary nucleus maturation GO:0021761 limbic system development GO:0021766 hippocampus development GO:0021795 cerebral cortex cell migration GO:0021799 cerebral cortex radially oriented cell migration GO:0021801 cerebral cortex radial glia guided migration GO:0021819 layer formation in cerebral cortex GO:0021885 forebrain cell migration GO:0021987 cerebral cortex development GO:0022029 telencephalon cell migration GO:0022030 telencephalon glial cell migration GO:0022037 metencephalon development GO:0022604 regulation of cell morphogenesis GO:0030308 negative regulation of cell growth GO:0030516 regulation of axon extension GO:0030517 negative regulation of axon extension GO:0030900 forebrain development GO:0030902 hindbrain development GO:0031345 negative regulation of cell projection organization GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032535 regulation of cellular component size GO:0032886 regulation of microtubule-based process GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0033136 serine phosphorylation of STAT3 protein GO:0033157 regulation of intracellular protein transport GO:0033674 positive regulation of kinase activity GO:0035235 ionotropic glutamate receptor signaling pathway GO:0042063 gliogenesis GO:0042501 serine phosphorylation of STAT protein GO:0043523 regulation of neuron apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0045665 negative regulation of neuron differentiation GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045860 positive regulation of protein kinase activity GO:0045926 negative regulation of growth GO:0046425 regulation of JAK-STAT cascade GO:0048013 ephrin receptor signaling pathway GO:0048511 rhythmic process GO:0048588 developmental cell growth GO:0048638 regulation of developmental growth GO:0048640 negative regulation of developmental growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0048813 dendrite morphogenesis GO:0048814 regulation of dendrite morphogenesis GO:0048857 neural nucleus development GO:0050768 negative regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050771 negative regulation of axonogenesis GO:0050773 regulation of dendrite development GO:0051222 positive regulation of protein transport GO:0051402 neuron apoptotic process GO:0051493 regulation of cytoskeleton organization GO:0051961 negative regulation of nervous system development GO:0060359 response to ammonium ion GO:0060560 developmental growth involved in morphogenesis GO:0060996 dendritic spine development GO:0060997 dendritic spine morphogenesis GO:0060998 regulation of dendritic spine development GO:0061001 regulation of dendritic spine morphogenesis GO:0061387 regulation of extent of cell growth GO:0061564 axon development GO:0070507 regulation of microtubule cytoskeleton organization GO:0070997 neuron death GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0071242 cellular response to ammonium ion GO:0071695 anatomical structure maturation GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072331 signal transduction by p53 class mediator GO:0072657 protein localization to membrane GO:0090066 regulation of anatomical structure size GO:0090068 positive regulation of cell cycle process GO:0090150 establishment of protein localization to membrane GO:0090313 regulation of protein targeting to membrane GO:0090314 positive regulation of protein targeting to membrane GO:0090316 positive regulation of intracellular protein transport GO:0095500 acetylcholine receptor signaling pathway GO:0097061 dendritic spine organization GO:0097485 neuron projection guidance GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1901796 regulation of signal transduction by p53 class mediator GO:1903533 regulation of protein targeting GO:1903829 positive regulation of cellular protein localization GO:1903831 signal transduction involved in cellular response to ammonium ion GO:1904029 regulation of cyclin-dependent protein kinase activity GO:1904892 regulation of STAT cascade GO:1904951 positive regulation of establishment of protein localization GO:1905144 response to acetylcholine GO:1905145 cellular response to acetylcholine GO:1990138 neuron projection extension |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0008047 enzyme activator activity GO:0016534 cyclin-dependent protein kinase 5 activator activity GO:0019207 kinase regulator activity GO:0019209 kinase activator activity GO:0019887 protein kinase regulator activity GO:0030295 protein kinase activator activity GO:0043539 protein serine/threonine kinase activator activity GO:0045296 cadherin binding GO:0046875 ephrin receptor binding GO:0050839 cell adhesion molecule binding GO:0097472 cyclin-dependent protein kinase activity |
Cellular Component |
GO:0014069 postsynaptic density GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex GO:0030424 axon GO:0030425 dendrite GO:0030426 growth cone GO:0030427 site of polarized growth GO:0031594 neuromuscular junction GO:0043025 neuronal cell body GO:0043197 dendritic spine GO:0043292 contractile fiber GO:0044297 cell body GO:0044309 neuron spine GO:0060076 excitatory synapse GO:0098794 postsynapse GO:0099572 postsynaptic specialization |
KEGG | - |
Reactome |
R-HSA-422475: Axon guidance R-HSA-399956: CRMPs in Sema3A signaling R-HSA-8862803: Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-8863678: Neurodegenerative Diseases R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation R-HSA-373755: Semaphorin interactions R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
---|---|
Symbol | CDK5R1 |
Name | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
Aliases | p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CDK5R1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CDK5R1 |
Name | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
Aliases | p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of CDK5R1 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | CDK5R1 |
Name | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
Aliases | p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CDK5R1 in various data sets.
|
Points in the above scatter plot represent the mutation difference of CDK5R1 in various data sets.
|
Summary | |
---|---|
Symbol | CDK5R1 |
Name | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
Aliases | p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDK5R1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CDK5R1 |
Name | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
Aliases | p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDK5R1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDK5R1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CDK5R1 |
Name | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
Aliases | p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDK5R1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CDK5R1 |
Name | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
Aliases | p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CDK5R1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CDK5R1 |
Name | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
Aliases | p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CDK5R1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CDK5R1 |
Name | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
Aliases | p35nck5a; Nck5a; CDK5P35; CDK5R; CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 regul ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CDK5R1 collected from DrugBank database. |
Details on drugs targeting CDK5R1.
|