Summary | |
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Symbol | CDK6 |
Name | cyclin-dependent kinase 6 |
Aliases | PLSTIRE; MCPH12; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (PubMed:23918663). |
Domain |
PF00069 Protein kinase domain |
Function |
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). |
Biological Process |
GO:0000082 G1/S transition of mitotic cell cycle GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001952 regulation of cell-matrix adhesion GO:0001954 positive regulation of cell-matrix adhesion GO:0002064 epithelial cell development GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0002066 columnar/cuboidal epithelial cell development GO:0002067 glandular epithelial cell differentiation GO:0002068 glandular epithelial cell development GO:0002244 hematopoietic progenitor cell differentiation GO:0002262 myeloid cell homeostasis GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002683 negative regulation of immune system process GO:0002761 regulation of myeloid leukocyte differentiation GO:0002762 negative regulation of myeloid leukocyte differentiation GO:0003309 type B pancreatic cell differentiation GO:0003323 type B pancreatic cell development GO:0007050 cell cycle arrest GO:0007159 leukocyte cell-cell adhesion GO:0007160 cell-matrix adhesion GO:0007219 Notch signaling pathway GO:0007568 aging GO:0007569 cell aging GO:0009615 response to virus GO:0010001 glial cell differentiation GO:0010810 regulation of cell-substrate adhesion GO:0010811 positive regulation of cell-substrate adhesion GO:0014002 astrocyte development GO:0021537 telencephalon development GO:0021542 dentate gyrus development GO:0021543 pallium development GO:0021591 ventricular system development GO:0021670 lateral ventricle development GO:0021761 limbic system development GO:0021766 hippocampus development GO:0021782 glial cell development GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030217 T cell differentiation GO:0030218 erythrocyte differentiation GO:0030224 monocyte differentiation GO:0030278 regulation of ossification GO:0030279 negative regulation of ossification GO:0030900 forebrain development GO:0031016 pancreas development GO:0031018 endocrine pancreas development GO:0031589 cell-substrate adhesion GO:0032844 regulation of homeostatic process GO:0033077 T cell differentiation in thymus GO:0034101 erythrocyte homeostasis GO:0035270 endocrine system development GO:0035883 enteroendocrine cell differentiation GO:0042063 gliogenesis GO:0042110 T cell activation GO:0043696 dedifferentiation GO:0043697 cell dedifferentiation GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044843 cell cycle G1/S phase transition GO:0045637 regulation of myeloid cell differentiation GO:0045638 negative regulation of myeloid cell differentiation GO:0045646 regulation of erythrocyte differentiation GO:0045655 regulation of monocyte differentiation GO:0045656 negative regulation of monocyte differentiation GO:0045667 regulation of osteoblast differentiation GO:0045668 negative regulation of osteoblast differentiation GO:0045785 positive regulation of cell adhesion GO:0045786 negative regulation of cell cycle GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048146 positive regulation of fibroblast proliferation GO:0048708 astrocyte differentiation GO:0048863 stem cell differentiation GO:0048872 homeostasis of number of cells GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050680 negative regulation of epithelial cell proliferation GO:0060218 hematopoietic stem cell differentiation GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071396 cellular response to lipid GO:0071593 lymphocyte aggregation GO:0071594 thymocyte aggregation GO:0090342 regulation of cell aging GO:0090344 negative regulation of cell aging GO:0090398 cellular senescence GO:1902105 regulation of leukocyte differentiation GO:1902106 negative regulation of leukocyte differentiation GO:1903131 mononuclear cell differentiation GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis GO:1904627 response to phorbol 13-acetate 12-myristate GO:1904628 cellular response to phorbol 13-acetate 12-myristate GO:2000772 regulation of cellular senescence GO:2000773 negative regulation of cellular senescence |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0030332 cyclin binding GO:0097472 cyclin-dependent protein kinase activity GO:0098770 FBXO family protein binding |
Cellular Component |
GO:0000307 cyclin-dependent protein kinase holoenzyme complex GO:0001726 ruffle GO:0005813 centrosome GO:0031252 cell leading edge GO:0061695 transferase complex, transferring phosphorus-containing groups GO:1902554 serine/threonine protein kinase complex GO:1902911 protein kinase complex |
KEGG |
hsa04110 Cell cycle hsa04115 p53 signaling pathway hsa04151 PI3K-Akt signaling pathway |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-69231: Cyclin D associated events in G1 R-HSA-69236: G1 Phase R-HSA-453279: Mitotic G1-G1/S phases R-HSA-2559585: Oncogene Induced Senescence R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-2559582: Senescence-Associated Secretory Phenotype (SASP) |
Summary | |
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Symbol | CDK6 |
Name | cyclin-dependent kinase 6 |
Aliases | PLSTIRE; MCPH12; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CDK6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CDK6 and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | CDK6 |
Name | cyclin-dependent kinase 6 |
Aliases | PLSTIRE; MCPH12; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CDK6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CDK6 |
Name | cyclin-dependent kinase 6 |
Aliases | PLSTIRE; MCPH12; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CDK6 in various data sets.
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Points in the above scatter plot represent the mutation difference of CDK6 in various data sets.
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Summary | |
---|---|
Symbol | CDK6 |
Name | cyclin-dependent kinase 6 |
Aliases | PLSTIRE; MCPH12; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDK6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CDK6 |
Name | cyclin-dependent kinase 6 |
Aliases | PLSTIRE; MCPH12; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDK6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDK6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CDK6 |
Name | cyclin-dependent kinase 6 |
Aliases | PLSTIRE; MCPH12; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDK6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CDK6 |
Name | cyclin-dependent kinase 6 |
Aliases | PLSTIRE; MCPH12; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CDK6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CDK6 |
Name | cyclin-dependent kinase 6 |
Aliases | PLSTIRE; MCPH12; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CDK6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CDK6 |
Name | cyclin-dependent kinase 6 |
Aliases | PLSTIRE; MCPH12; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CDK6 collected from DrugBank database. |
Details on drugs targeting CDK6.
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