Summary | |
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Symbol | CDON |
Name | cell adhesion associated, oncogene regulated |
Aliases | ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass membrane protein |
Domain |
PF00041 Fibronectin type III domain PF07679 Immunoglobulin I-set domain |
Function |
Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity). |
Biological Process |
GO:0000768 syncytium formation by plasma membrane fusion GO:0001654 eye development GO:0001708 cell fate specification GO:0002088 lens development in camera-type eye GO:0003002 regionalization GO:0006949 syncytium formation GO:0007224 smoothened signaling pathway GO:0007389 pattern specification process GO:0007423 sensory organ development GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0007520 myoblast fusion GO:0009952 anterior/posterior pattern specification GO:0010171 body morphogenesis GO:0010172 embryonic body morphogenesis GO:0010720 positive regulation of cell development GO:0014706 striated muscle tissue development GO:0014816 skeletal muscle satellite cell differentiation GO:0014902 myotube differentiation GO:0016202 regulation of striated muscle tissue development GO:0021537 telencephalon development GO:0021543 pallium development GO:0021987 cerebral cortex development GO:0030900 forebrain development GO:0035914 skeletal muscle cell differentiation GO:0042692 muscle cell differentiation GO:0043010 camera-type eye development GO:0043393 regulation of protein binding GO:0043410 positive regulation of MAPK cascade GO:0043497 regulation of protein heterodimerization activity GO:0045165 cell fate commitment GO:0045445 myoblast differentiation GO:0045661 regulation of myoblast differentiation GO:0045663 positive regulation of myoblast differentiation GO:0045666 positive regulation of neuron differentiation GO:0045844 positive regulation of striated muscle tissue development GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0048634 regulation of muscle organ development GO:0048636 positive regulation of muscle organ development GO:0048641 regulation of skeletal muscle tissue development GO:0048643 positive regulation of skeletal muscle tissue development GO:0050769 positive regulation of neurogenesis GO:0051056 regulation of small GTPase mediated signal transduction GO:0051057 positive regulation of small GTPase mediated signal transduction GO:0051098 regulation of binding GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051149 positive regulation of muscle cell differentiation GO:0051962 positive regulation of nervous system development GO:0060041 retina development in camera-type eye GO:0060042 retina morphogenesis in camera-type eye GO:0060059 embryonic retina morphogenesis in camera-type eye GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0061351 neural precursor cell proliferation GO:0090596 sensory organ morphogenesis GO:1901861 regulation of muscle tissue development GO:1901863 positive regulation of muscle tissue development GO:2000177 regulation of neural precursor cell proliferation GO:2000179 positive regulation of neural precursor cell proliferation |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04340 Hedgehog signaling pathway |
Reactome |
R-HSA-5635838: Activation of SMO R-HSA-375170: CDO in myogenesis R-HSA-1266738: Developmental Biology R-HSA-5632684: Hedgehog 'on' state R-HSA-5632681: Ligand-receptor interactions R-HSA-525793: Myogenesis R-HSA-162582: Signal Transduction R-HSA-5358351: Signaling by Hedgehog |
Summary | |
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Symbol | CDON |
Name | cell adhesion associated, oncogene regulated |
Aliases | ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CDON and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CDON |
Name | cell adhesion associated, oncogene regulated |
Aliases | ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CDON in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | CDON |
Name | cell adhesion associated, oncogene regulated |
Aliases | ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CDON in various data sets.
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Points in the above scatter plot represent the mutation difference of CDON in various data sets.
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Summary | |
---|---|
Symbol | CDON |
Name | cell adhesion associated, oncogene regulated |
Aliases | ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDON. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CDON |
Name | cell adhesion associated, oncogene regulated |
Aliases | ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDON. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDON. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CDON |
Name | cell adhesion associated, oncogene regulated |
Aliases | ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDON. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CDON |
Name | cell adhesion associated, oncogene regulated |
Aliases | ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CDON expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CDON |
Name | cell adhesion associated, oncogene regulated |
Aliases | ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CDON and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CDON |
Name | cell adhesion associated, oncogene regulated |
Aliases | ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CDON collected from DrugBank database. |
There is no record. |