Browse CDX2

Summary
SymbolCDX2
Namecaudal type homeobox 2
Aliases CDX3; caudal type homeo box transcription factor 2; CDX-3/AS; caudal type homeobox transcription factor 2; c ......
Chromosomal Location13q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF04731 Caudal like protein activation region
PF00046 Homeobox domain
Function

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536).

> Gene Ontology
 
Biological Process GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0001824 blastocyst development
GO:0001825 blastocyst formation
GO:0001829 trophectodermal cell differentiation
GO:0001890 placenta development
GO:0001892 embryonic placenta development
GO:0002065 columnar/cuboidal epithelial cell differentiation
GO:0003002 regionalization
GO:0007034 vacuolar transport
GO:0007041 lysosomal transport
GO:0007163 establishment or maintenance of cell polarity
GO:0007389 pattern specification process
GO:0008333 endosome to lysosome transport
GO:0009798 axis specification
GO:0009948 anterior/posterior axis specification
GO:0009952 anterior/posterior pattern specification
GO:0014807 regulation of somitogenesis
GO:0016197 endosomal transport
GO:0019827 stem cell population maintenance
GO:0035019 somatic stem cell population maintenance
GO:0035088 establishment or maintenance of apical/basal cell polarity
GO:0035282 segmentation
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045995 regulation of embryonic development
GO:0048565 digestive tract development
GO:0048568 embryonic organ development
GO:0048608 reproductive structure development
GO:0055123 digestive system development
GO:0060575 intestinal epithelial cell differentiation
GO:0060711 labyrinthine layer development
GO:0061053 somite development
GO:0061245 establishment or maintenance of bipolar cell polarity
GO:0061458 reproductive system development
GO:0098727 maintenance of cell number
Molecular Function GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001158 enhancer sequence-specific DNA binding
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003714 transcription corepressor activity
GO:0035326 enhancer binding
Cellular Component GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0017053 transcriptional repressor complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1266738: Developmental Biology
R-HSA-400508: Incretin synthesis, secretion, and inactivation
R-HSA-392499: Metabolism of proteins
R-HSA-2892245: POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
R-HSA-2980736: Peptide hormone metabolism
R-HSA-381771: Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-452723: Transcriptional regulation of pluripotent stem cells
Summary
SymbolCDX2
Namecaudal type homeobox 2
Aliases CDX3; caudal type homeo box transcription factor 2; CDX-3/AS; caudal type homeobox transcription factor 2; c ......
Chromosomal Location13q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CDX2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CDX2 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
27813511Colorectal CancinomaPromote immunityAberrantly expressed CD274 allows tumor cells to evade host immune system and is considered to be a mechanism of adaptive immune resistance. Moreover, colorectal carcinomas characterized by lack of CDX2 and prominent expression of ALCAM frequently (71%) showed CD274 positivity. This might suggest association of CD274 expression with 'stem-like' phenotype.
Summary
SymbolCDX2
Namecaudal type homeobox 2
Aliases CDX3; caudal type homeo box transcription factor 2; CDX-3/AS; caudal type homeobox transcription factor 2; c ......
Chromosomal Location13q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CDX2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCDX2
Namecaudal type homeobox 2
Aliases CDX3; caudal type homeo box transcription factor 2; CDX-3/AS; caudal type homeobox transcription factor 2; c ......
Chromosomal Location13q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CDX2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.6450.296
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.7030.481
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.5720.615
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.3350.316
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CDX2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCDX2
Namecaudal type homeobox 2
Aliases CDX3; caudal type homeo box transcription factor 2; CDX-3/AS; caudal type homeobox transcription factor 2; c ......
Chromosomal Location13q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDX2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCDX2
Namecaudal type homeobox 2
Aliases CDX3; caudal type homeo box transcription factor 2; CDX-3/AS; caudal type homeobox transcription factor 2; c ......
Chromosomal Location13q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDX2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDX2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCDX2
Namecaudal type homeobox 2
Aliases CDX3; caudal type homeo box transcription factor 2; CDX-3/AS; caudal type homeobox transcription factor 2; c ......
Chromosomal Location13q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDX2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCDX2
Namecaudal type homeobox 2
Aliases CDX3; caudal type homeo box transcription factor 2; CDX-3/AS; caudal type homeobox transcription factor 2; c ......
Chromosomal Location13q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CDX2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCDX2
Namecaudal type homeobox 2
Aliases CDX3; caudal type homeo box transcription factor 2; CDX-3/AS; caudal type homeobox transcription factor 2; c ......
Chromosomal Location13q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CDX2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCDX2
Namecaudal type homeobox 2
Aliases CDX3; caudal type homeo box transcription factor 2; CDX-3/AS; caudal type homeobox transcription factor 2; c ......
Chromosomal Location13q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CDX2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.