Summary | |
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Symbol | CEACAM5 |
Name | carcinoembryonic antigen-related cell adhesion molecule 5 |
Aliases | CD66e; meconium antigen 100; CD antigen CD66e; Carcinoembryonic antigen |
Chromosomal Location | 19q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor, GPI-anchor |
Domain |
PF13895 Immunoglobulin domain PF07686 Immunoglobulin V-set domain |
Function |
Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. |
Biological Process |
GO:0010830 regulation of myotube differentiation GO:0010832 negative regulation of myotube differentiation GO:0014902 myotube differentiation GO:0034109 homotypic cell-cell adhesion GO:0042692 muscle cell differentiation GO:0043276 anoikis GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051148 negative regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051154 negative regulation of striated muscle cell differentiation GO:2000209 regulation of anoikis GO:2000811 negative regulation of anoikis |
Molecular Function |
GO:0005543 phospholipid binding GO:0034235 GPI anchor binding GO:0035091 phosphatidylinositol binding GO:0051861 glycolipid binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0016323 basolateral plasma membrane GO:0031225 anchored component of membrane GO:0031233 intrinsic component of external side of plasma membrane GO:0071575 integral component of external side of plasma membrane GO:0098552 side of membrane |
KEGG | - |
Reactome |
R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-109582: Hemostasis R-HSA-392499: Metabolism of proteins R-HSA-163125: Post-translational modification R-HSA-597592: Post-translational protein modification |
Summary | |
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Symbol | CEACAM5 |
Name | carcinoembryonic antigen-related cell adhesion molecule 5 |
Aliases | CD66e; meconium antigen 100; CD antigen CD66e; Carcinoembryonic antigen |
Chromosomal Location | 19q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CEACAM5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CEACAM5 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CEACAM5 |
Name | carcinoembryonic antigen-related cell adhesion molecule 5 |
Aliases | CD66e; meconium antigen 100; CD antigen CD66e; Carcinoembryonic antigen |
Chromosomal Location | 19q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CEACAM5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CEACAM5 |
Name | carcinoembryonic antigen-related cell adhesion molecule 5 |
Aliases | CD66e; meconium antigen 100; CD antigen CD66e; Carcinoembryonic antigen |
Chromosomal Location | 19q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CEACAM5 in various data sets.
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Points in the above scatter plot represent the mutation difference of CEACAM5 in various data sets.
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Summary | |
---|---|
Symbol | CEACAM5 |
Name | carcinoembryonic antigen-related cell adhesion molecule 5 |
Aliases | CD66e; meconium antigen 100; CD antigen CD66e; Carcinoembryonic antigen |
Chromosomal Location | 19q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CEACAM5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CEACAM5 |
Name | carcinoembryonic antigen-related cell adhesion molecule 5 |
Aliases | CD66e; meconium antigen 100; CD antigen CD66e; Carcinoembryonic antigen |
Chromosomal Location | 19q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CEACAM5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CEACAM5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CEACAM5 |
Name | carcinoembryonic antigen-related cell adhesion molecule 5 |
Aliases | CD66e; meconium antigen 100; CD antigen CD66e; Carcinoembryonic antigen |
Chromosomal Location | 19q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CEACAM5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CEACAM5 |
Name | carcinoembryonic antigen-related cell adhesion molecule 5 |
Aliases | CD66e; meconium antigen 100; CD antigen CD66e; Carcinoembryonic antigen |
Chromosomal Location | 19q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CEACAM5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CEACAM5 |
Name | carcinoembryonic antigen-related cell adhesion molecule 5 |
Aliases | CD66e; meconium antigen 100; CD antigen CD66e; Carcinoembryonic antigen |
Chromosomal Location | 19q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CEACAM5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CEACAM5 |
Name | carcinoembryonic antigen-related cell adhesion molecule 5 |
Aliases | CD66e; meconium antigen 100; CD antigen CD66e; Carcinoembryonic antigen |
Chromosomal Location | 19q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CEACAM5 collected from DrugBank database. |
Details on drugs targeting CEACAM5.
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