Summary | |
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Symbol | CEBPB |
Name | CCAAT/enhancer binding protein (C/EBP), beta |
Aliases | NFIL6; IL6DBP; C/EBP-beta; liver-enriched transcriptional activator protein; nuclear factor of interleukin 6 ...... |
Chromosomal Location | 20q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm Note=Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity). |
Domain |
PF07716 Basic region leucine zipper |
Function |
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). ; FUNCTION: Isoform 2: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. ; FUNCTION: Isoform 3: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). |
Biological Process |
GO:0001101 response to acid chemical GO:0001503 ossification GO:0001541 ovarian follicle development GO:0001649 osteoblast differentiation GO:0001701 in utero embryonic development GO:0001819 positive regulation of cytokine production GO:0001889 liver development GO:0001890 placenta development GO:0001892 embryonic placenta development GO:0002237 response to molecule of bacterial origin GO:0002432 granuloma formation GO:0002521 leukocyte differentiation GO:0002526 acute inflammatory response GO:0002544 chronic inflammatory response GO:0002573 myeloid leukocyte differentiation GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002761 regulation of myeloid leukocyte differentiation GO:0006953 acute-phase response GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0007548 sex differentiation GO:0007611 learning or memory GO:0007613 memory GO:0008406 gonad development GO:0008585 female gonad development GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0022602 ovulation cycle process GO:0022612 gland morphogenesis GO:0030099 myeloid cell differentiation GO:0030278 regulation of ossification GO:0030316 osteoclast differentiation GO:0030879 mammary gland development GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0032496 response to lipopolysaccharide GO:0032633 interleukin-4 production GO:0032635 interleukin-6 production GO:0032673 regulation of interleukin-4 production GO:0032675 regulation of interleukin-6 production GO:0032753 positive regulation of interleukin-4 production GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032945 negative regulation of mononuclear cell proliferation GO:0033598 mammary gland epithelial cell proliferation GO:0034976 response to endoplasmic reticulum stress GO:0035710 CD4-positive, alpha-beta T cell activation GO:0035711 T-helper 1 cell activation GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0042035 regulation of cytokine biosynthetic process GO:0042089 cytokine biosynthetic process GO:0042098 T cell proliferation GO:0042107 cytokine metabolic process GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042130 negative regulation of T cell proliferation GO:0042226 interleukin-6 biosynthetic process GO:0042698 ovulation cycle GO:0042742 defense response to bacterium GO:0043200 response to amino acid GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043620 regulation of DNA-templated transcription in response to stress GO:0044708 single-organism behavior GO:0045137 development of primary sexual characteristics GO:0045165 cell fate commitment GO:0045408 regulation of interleukin-6 biosynthetic process GO:0045444 fat cell differentiation GO:0045598 regulation of fat cell differentiation GO:0045600 positive regulation of fat cell differentiation GO:0045637 regulation of myeloid cell differentiation GO:0045667 regulation of osteoblast differentiation GO:0045669 positive regulation of osteoblast differentiation GO:0045670 regulation of osteoclast differentiation GO:0045778 positive regulation of ossification GO:0046545 development of primary female sexual characteristics GO:0046631 alpha-beta T cell activation GO:0046651 lymphocyte proliferation GO:0046660 female sex differentiation GO:0048511 rhythmic process GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0048732 gland development GO:0050670 regulation of lymphocyte proliferation GO:0050672 negative regulation of lymphocyte proliferation GO:0050673 epithelial cell proliferation GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0050873 brown fat cell differentiation GO:0050890 cognition GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051402 neuron apoptotic process GO:0060644 mammary gland epithelial cell differentiation GO:0060850 regulation of transcription involved in cell fate commitment GO:0061008 hepaticobiliary system development GO:0061180 mammary gland epithelium development GO:0061458 reproductive system development GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070555 response to interleukin-1 GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070664 negative regulation of leukocyte proliferation GO:0070997 neuron death GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071229 cellular response to acid chemical GO:0071230 cellular response to amino acid stimulus GO:0071347 cellular response to interleukin-1 GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071593 lymphocyte aggregation GO:0072574 hepatocyte proliferation GO:0072575 epithelial cell proliferation involved in liver morphogenesis GO:0072576 liver morphogenesis GO:0097193 intrinsic apoptotic signaling pathway GO:0097421 liver regeneration GO:0098542 defense response to other organism GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1902105 regulation of leukocyte differentiation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion GO:1903706 regulation of hemopoiesis GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0008134 transcription factor binding GO:0035035 histone acetyltransferase binding GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0035259 glucocorticoid receptor binding GO:0042826 histone deacetylase binding GO:0044389 ubiquitin-like protein ligase binding GO:0046982 protein heterodimerization activity GO:0051427 hormone receptor binding |
Cellular Component |
GO:0000775 chromosome, centromeric region GO:0000779 condensed chromosome, centromeric region GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000793 condensed chromosome GO:0005667 transcription factor complex GO:0016363 nuclear matrix GO:0034399 nuclear periphery GO:0036488 CHOP-C/EBP complex GO:0044454 nuclear chromosome part GO:0044798 nuclear transcription factor complex GO:0090575 RNA polymerase II transcription factor complex GO:0098687 chromosomal region |
KEGG |
hsa04668 TNF signaling pathway |
Reactome |
R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-1266738: Developmental Biology R-HSA-2559582: Senescence-Associated Secretory Phenotype (SASP) R-HSA-381340: Transcriptional regulation of white adipocyte differentiation |
Summary | |
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Symbol | CEBPB |
Name | CCAAT/enhancer binding protein (C/EBP), beta |
Aliases | NFIL6; IL6DBP; C/EBP-beta; liver-enriched transcriptional activator protein; nuclear factor of interleukin 6 ...... |
Chromosomal Location | 20q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CEBPB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CEBPB and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CEBPB |
Name | CCAAT/enhancer binding protein (C/EBP), beta |
Aliases | NFIL6; IL6DBP; C/EBP-beta; liver-enriched transcriptional activator protein; nuclear factor of interleukin 6 ...... |
Chromosomal Location | 20q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CEBPB in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CEBPB |
Name | CCAAT/enhancer binding protein (C/EBP), beta |
Aliases | NFIL6; IL6DBP; C/EBP-beta; liver-enriched transcriptional activator protein; nuclear factor of interleukin 6 ...... |
Chromosomal Location | 20q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CEBPB in various data sets.
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Points in the above scatter plot represent the mutation difference of CEBPB in various data sets.
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Summary | |
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Symbol | CEBPB |
Name | CCAAT/enhancer binding protein (C/EBP), beta |
Aliases | NFIL6; IL6DBP; C/EBP-beta; liver-enriched transcriptional activator protein; nuclear factor of interleukin 6 ...... |
Chromosomal Location | 20q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CEBPB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CEBPB |
Name | CCAAT/enhancer binding protein (C/EBP), beta |
Aliases | NFIL6; IL6DBP; C/EBP-beta; liver-enriched transcriptional activator protein; nuclear factor of interleukin 6 ...... |
Chromosomal Location | 20q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CEBPB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CEBPB. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CEBPB |
Name | CCAAT/enhancer binding protein (C/EBP), beta |
Aliases | NFIL6; IL6DBP; C/EBP-beta; liver-enriched transcriptional activator protein; nuclear factor of interleukin 6 ...... |
Chromosomal Location | 20q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CEBPB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CEBPB |
Name | CCAAT/enhancer binding protein (C/EBP), beta |
Aliases | NFIL6; IL6DBP; C/EBP-beta; liver-enriched transcriptional activator protein; nuclear factor of interleukin 6 ...... |
Chromosomal Location | 20q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CEBPB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CEBPB |
Name | CCAAT/enhancer binding protein (C/EBP), beta |
Aliases | NFIL6; IL6DBP; C/EBP-beta; liver-enriched transcriptional activator protein; nuclear factor of interleukin 6 ...... |
Chromosomal Location | 20q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CEBPB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CEBPB |
Name | CCAAT/enhancer binding protein (C/EBP), beta |
Aliases | NFIL6; IL6DBP; C/EBP-beta; liver-enriched transcriptional activator protein; nuclear factor of interleukin 6 ...... |
Chromosomal Location | 20q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CEBPB collected from DrugBank database. |
Details on drugs targeting CEBPB.
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