Summary | |
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Symbol | CEBPD |
Name | CCAAT/enhancer binding protein (C/EBP), delta |
Aliases | CELF; C/EBP-delta; NF-IL6-beta; c/EBP delta; nuclear factor NF-IL6-beta; CCAAT/enhancer-binding protein delt ...... |
Chromosomal Location | 8p11.2-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF07716 Basic region leucine zipper |
Function |
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402). |
Biological Process |
GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0002244 hematopoietic progenitor cell differentiation GO:0007423 sensory organ development GO:0030278 regulation of ossification GO:0043583 ear development GO:0045444 fat cell differentiation GO:0045667 regulation of osteoblast differentiation GO:0045669 positive regulation of osteoblast differentiation GO:0045778 positive regulation of ossification GO:0048839 inner ear development |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0046982 protein heterodimerization activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1266738: Developmental Biology R-HSA-168256: Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-449147: Signaling by Interleukins R-HSA-381340: Transcriptional regulation of white adipocyte differentiation |
Summary | |
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Symbol | CEBPD |
Name | CCAAT/enhancer binding protein (C/EBP), delta |
Aliases | CELF; C/EBP-delta; NF-IL6-beta; c/EBP delta; nuclear factor NF-IL6-beta; CCAAT/enhancer-binding protein delt ...... |
Chromosomal Location | 8p11.2-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CEBPD and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CEBPD and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CEBPD |
Name | CCAAT/enhancer binding protein (C/EBP), delta |
Aliases | CELF; C/EBP-delta; NF-IL6-beta; c/EBP delta; nuclear factor NF-IL6-beta; CCAAT/enhancer-binding protein delt ...... |
Chromosomal Location | 8p11.2-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CEBPD in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CEBPD |
Name | CCAAT/enhancer binding protein (C/EBP), delta |
Aliases | CELF; C/EBP-delta; NF-IL6-beta; c/EBP delta; nuclear factor NF-IL6-beta; CCAAT/enhancer-binding protein delt ...... |
Chromosomal Location | 8p11.2-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CEBPD in various data sets.
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Points in the above scatter plot represent the mutation difference of CEBPD in various data sets.
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Summary | |
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Symbol | CEBPD |
Name | CCAAT/enhancer binding protein (C/EBP), delta |
Aliases | CELF; C/EBP-delta; NF-IL6-beta; c/EBP delta; nuclear factor NF-IL6-beta; CCAAT/enhancer-binding protein delt ...... |
Chromosomal Location | 8p11.2-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CEBPD. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CEBPD |
Name | CCAAT/enhancer binding protein (C/EBP), delta |
Aliases | CELF; C/EBP-delta; NF-IL6-beta; c/EBP delta; nuclear factor NF-IL6-beta; CCAAT/enhancer-binding protein delt ...... |
Chromosomal Location | 8p11.2-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CEBPD. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CEBPD. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CEBPD |
Name | CCAAT/enhancer binding protein (C/EBP), delta |
Aliases | CELF; C/EBP-delta; NF-IL6-beta; c/EBP delta; nuclear factor NF-IL6-beta; CCAAT/enhancer-binding protein delt ...... |
Chromosomal Location | 8p11.2-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CEBPD. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CEBPD |
Name | CCAAT/enhancer binding protein (C/EBP), delta |
Aliases | CELF; C/EBP-delta; NF-IL6-beta; c/EBP delta; nuclear factor NF-IL6-beta; CCAAT/enhancer-binding protein delt ...... |
Chromosomal Location | 8p11.2-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CEBPD expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CEBPD |
Name | CCAAT/enhancer binding protein (C/EBP), delta |
Aliases | CELF; C/EBP-delta; NF-IL6-beta; c/EBP delta; nuclear factor NF-IL6-beta; CCAAT/enhancer-binding protein delt ...... |
Chromosomal Location | 8p11.2-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CEBPD and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CEBPD |
Name | CCAAT/enhancer binding protein (C/EBP), delta |
Aliases | CELF; C/EBP-delta; NF-IL6-beta; c/EBP delta; nuclear factor NF-IL6-beta; CCAAT/enhancer-binding protein delt ...... |
Chromosomal Location | 8p11.2-p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CEBPD collected from DrugBank database. |
There is no record. |