Summary | |
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Symbol | CEBPG |
Name | CCAAT/enhancer binding protein (C/EBP), gamma |
Aliases | GPE1BP; IG/EBP-1; c/EBP gamma; CCAAT/enhancer-binding protein gamma |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF07716 Basic region leucine zipper |
Function |
Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter. |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0001889 liver development GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0002228 natural killer cell mediated immunity GO:0002262 myeloid cell homeostasis GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002521 leukocyte differentiation GO:0006282 regulation of DNA repair GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030183 B cell differentiation GO:0030218 erythrocyte differentiation GO:0032609 interferon-gamma production GO:0032649 regulation of interferon-gamma production GO:0032729 positive regulation of interferon-gamma production GO:0034101 erythrocyte homeostasis GO:0042035 regulation of cytokine biosynthetic process GO:0042089 cytokine biosynthetic process GO:0042095 interferon-gamma biosynthetic process GO:0042107 cytokine metabolic process GO:0042108 positive regulation of cytokine biosynthetic process GO:0042113 B cell activation GO:0042267 natural killer cell mediated cytotoxicity GO:0043353 enucleate erythrocyte differentiation GO:0043388 positive regulation of DNA binding GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0045072 regulation of interferon-gamma biosynthetic process GO:0045078 positive regulation of interferon-gamma biosynthetic process GO:0045739 positive regulation of DNA repair GO:0048732 gland development GO:0048872 homeostasis of number of cells GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051101 regulation of DNA binding GO:0061008 hepaticobiliary system development GO:2001020 regulation of response to DNA damage stimulus GO:2001022 positive regulation of response to DNA damage stimulus |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0008134 transcription factor binding GO:0008301 DNA binding, bending GO:0044374 sequence-specific DNA binding, bending GO:0044377 RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending GO:0046982 protein heterodimerization activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | CEBPG |
Name | CCAAT/enhancer binding protein (C/EBP), gamma |
Aliases | GPE1BP; IG/EBP-1; c/EBP gamma; CCAAT/enhancer-binding protein gamma |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CEBPG and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CEBPG |
Name | CCAAT/enhancer binding protein (C/EBP), gamma |
Aliases | GPE1BP; IG/EBP-1; c/EBP gamma; CCAAT/enhancer-binding protein gamma |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CEBPG in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | CEBPG |
Name | CCAAT/enhancer binding protein (C/EBP), gamma |
Aliases | GPE1BP; IG/EBP-1; c/EBP gamma; CCAAT/enhancer-binding protein gamma |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CEBPG in various data sets.
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Points in the above scatter plot represent the mutation difference of CEBPG in various data sets.
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Summary | |
---|---|
Symbol | CEBPG |
Name | CCAAT/enhancer binding protein (C/EBP), gamma |
Aliases | GPE1BP; IG/EBP-1; c/EBP gamma; CCAAT/enhancer-binding protein gamma |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CEBPG. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CEBPG |
Name | CCAAT/enhancer binding protein (C/EBP), gamma |
Aliases | GPE1BP; IG/EBP-1; c/EBP gamma; CCAAT/enhancer-binding protein gamma |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CEBPG. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CEBPG. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CEBPG |
Name | CCAAT/enhancer binding protein (C/EBP), gamma |
Aliases | GPE1BP; IG/EBP-1; c/EBP gamma; CCAAT/enhancer-binding protein gamma |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CEBPG. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CEBPG |
Name | CCAAT/enhancer binding protein (C/EBP), gamma |
Aliases | GPE1BP; IG/EBP-1; c/EBP gamma; CCAAT/enhancer-binding protein gamma |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CEBPG expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CEBPG |
Name | CCAAT/enhancer binding protein (C/EBP), gamma |
Aliases | GPE1BP; IG/EBP-1; c/EBP gamma; CCAAT/enhancer-binding protein gamma |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CEBPG and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CEBPG |
Name | CCAAT/enhancer binding protein (C/EBP), gamma |
Aliases | GPE1BP; IG/EBP-1; c/EBP gamma; CCAAT/enhancer-binding protein gamma |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CEBPG collected from DrugBank database. |
There is no record. |