Summary | |
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Symbol | CELSR1 |
Name | cadherin, EGF LAG seven-pass G-type receptor 1 |
Aliases | HFMI2; FMI2; CDHF9; ADGRC1; flamingo homolog 2 (Drosophila); adhesion G protein-coupled receptor C1; cadheri ...... |
Chromosomal Location | 22q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00002 7 transmembrane receptor (Secretin family) PF00028 Cadherin domain PF00008 EGF-like domain PF16489 GPCR-Autoproteolysis INducing (GAIN) domain PF01825 GPCR proteolysis site PF02793 Hormone receptor domain PF00053 Laminin EGF domain PF02210 Laminin G domain |
Function |
Receptor that may have an important role in cell/cell signaling during nervous system formation. |
Biological Process |
GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0001763 morphogenesis of a branching structure GO:0001764 neuron migration GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0001942 hair follicle development GO:0003002 regionalization GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007164 establishment of tissue polarity GO:0007265 Ras protein signal transduction GO:0007266 Rho protein signal transduction GO:0007389 pattern specification process GO:0007423 sensory organ development GO:0007626 locomotory behavior GO:0008105 asymmetric protein localization GO:0008544 epidermis development GO:0009952 anterior/posterior pattern specification GO:0014020 primary neural tube formation GO:0016055 Wnt signaling pathway GO:0016331 morphogenesis of embryonic epithelium GO:0021915 neural tube development GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0030323 respiratory tube development GO:0030324 lung development GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035567 non-canonical Wnt signaling pathway GO:0042249 establishment of planar polarity of embryonic epithelium GO:0042303 molting cycle GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0042633 hair cycle GO:0043583 ear development GO:0043588 skin development GO:0045176 apical protein localization GO:0045995 regulation of embryonic development GO:0048104 establishment of body hair or bristle planar orientation GO:0048105 establishment of body hair planar orientation GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048754 branching morphogenesis of an epithelial tube GO:0048839 inner ear development GO:0051493 regulation of cytoskeleton organization GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0060425 lung morphogenesis GO:0060441 epithelial tube branching involved in lung morphogenesis GO:0060448 dichotomous subdivision of terminal units involved in lung branching GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis GO:0060489 planar dichotomous subdivision of terminal units involved in lung branching morphogenesis GO:0060490 lateral sprouting involved in lung morphogenesis GO:0060541 respiratory system development GO:0060562 epithelial tube morphogenesis GO:0060600 dichotomous subdivision of an epithelial terminal unit GO:0060601 lateral sprouting from an epithelium GO:0060606 tube closure GO:0061138 morphogenesis of a branching epithelium GO:0072175 epithelial tube formation GO:0090175 regulation of establishment of planar polarity GO:0090177 establishment of planar polarity involved in neural tube closure GO:0090178 regulation of establishment of planar polarity involved in neural tube closure GO:0090179 planar cell polarity pathway involved in neural tube closure GO:0090251 protein localization involved in establishment of planar polarity GO:0090596 sensory organ morphogenesis GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098773 skin epidermis development GO:0198738 cell-cell signaling by wnt GO:1905276 regulation of epithelial tube formation GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | CELSR1 |
Name | cadherin, EGF LAG seven-pass G-type receptor 1 |
Aliases | HFMI2; FMI2; CDHF9; ADGRC1; flamingo homolog 2 (Drosophila); adhesion G protein-coupled receptor C1; cadheri ...... |
Chromosomal Location | 22q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CELSR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CELSR1 |
Name | cadherin, EGF LAG seven-pass G-type receptor 1 |
Aliases | HFMI2; FMI2; CDHF9; ADGRC1; flamingo homolog 2 (Drosophila); adhesion G protein-coupled receptor C1; cadheri ...... |
Chromosomal Location | 22q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CELSR1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CELSR1 |
Name | cadherin, EGF LAG seven-pass G-type receptor 1 |
Aliases | HFMI2; FMI2; CDHF9; ADGRC1; flamingo homolog 2 (Drosophila); adhesion G protein-coupled receptor C1; cadheri ...... |
Chromosomal Location | 22q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CELSR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of CELSR1 in various data sets.
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Summary | |
---|---|
Symbol | CELSR1 |
Name | cadherin, EGF LAG seven-pass G-type receptor 1 |
Aliases | HFMI2; FMI2; CDHF9; ADGRC1; flamingo homolog 2 (Drosophila); adhesion G protein-coupled receptor C1; cadheri ...... |
Chromosomal Location | 22q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CELSR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CELSR1 |
Name | cadherin, EGF LAG seven-pass G-type receptor 1 |
Aliases | HFMI2; FMI2; CDHF9; ADGRC1; flamingo homolog 2 (Drosophila); adhesion G protein-coupled receptor C1; cadheri ...... |
Chromosomal Location | 22q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CELSR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CELSR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CELSR1 |
Name | cadherin, EGF LAG seven-pass G-type receptor 1 |
Aliases | HFMI2; FMI2; CDHF9; ADGRC1; flamingo homolog 2 (Drosophila); adhesion G protein-coupled receptor C1; cadheri ...... |
Chromosomal Location | 22q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CELSR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CELSR1 |
Name | cadherin, EGF LAG seven-pass G-type receptor 1 |
Aliases | HFMI2; FMI2; CDHF9; ADGRC1; flamingo homolog 2 (Drosophila); adhesion G protein-coupled receptor C1; cadheri ...... |
Chromosomal Location | 22q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CELSR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CELSR1 |
Name | cadherin, EGF LAG seven-pass G-type receptor 1 |
Aliases | HFMI2; FMI2; CDHF9; ADGRC1; flamingo homolog 2 (Drosophila); adhesion G protein-coupled receptor C1; cadheri ...... |
Chromosomal Location | 22q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CELSR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CELSR1 |
Name | cadherin, EGF LAG seven-pass G-type receptor 1 |
Aliases | HFMI2; FMI2; CDHF9; ADGRC1; flamingo homolog 2 (Drosophila); adhesion G protein-coupled receptor C1; cadheri ...... |
Chromosomal Location | 22q13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CELSR1 collected from DrugBank database. |
There is no record. |