Summary | |
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Symbol | CENPQ |
Name | centromere protein Q |
Aliases | FLJ10545; CENP-Q; C6orf139; chromosome 6 open reading frame 139 |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Chromosome, centromere Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. |
Domain |
PF13094 CENP-Q |
Function |
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). |
Biological Process |
GO:0000819 sister chromatid segregation GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0006336 DNA replication-independent nucleosome assembly GO:0006338 chromatin remodeling GO:0007059 chromosome segregation GO:0007062 sister chromatid cohesion GO:0031055 chromatin remodeling at centromere GO:0031497 chromatin assembly GO:0034080 CENP-A containing nucleosome assembly GO:0034501 protein localization to kinetochore GO:0034502 protein localization to chromosome GO:0034508 centromere complex assembly GO:0034724 DNA replication-independent nucleosome organization GO:0034728 nucleosome organization GO:0043044 ATP-dependent chromatin remodeling GO:0043486 histone exchange GO:0050000 chromosome localization GO:0051303 establishment of chromosome localization GO:0051310 metaphase plate congression GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0061641 CENP-A containing chromatin organization GO:0065004 protein-DNA complex assembly GO:0071103 DNA conformation change GO:0071459 protein localization to chromosome, centromeric region GO:0071824 protein-DNA complex subunit organization GO:0098813 nuclear chromosome segregation GO:1903829 positive regulation of cellular protein localization GO:1905340 regulation of protein localization to kinetochore GO:1905342 positive regulation of protein localization to kinetochore |
Molecular Function | - |
Cellular Component |
GO:0000775 chromosome, centromeric region GO:0015629 actin cytoskeleton GO:0098687 chromosomal region |
KEGG | - |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-73886: Chromosome Maintenance R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-68886: M Phase R-HSA-68882: Mitotic Anaphase R-HSA-2555396: Mitotic Metaphase and Anaphase R-HSA-68877: Mitotic Prometaphase R-HSA-774815: Nucleosome assembly R-HSA-195258: RHO GTPase Effectors R-HSA-5663220: RHO GTPases Activate Formins R-HSA-2500257: Resolution of Sister Chromatid Cohesion R-HSA-2467813: Separation of Sister Chromatids R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases |
Summary | |
---|---|
Symbol | CENPQ |
Name | centromere protein Q |
Aliases | FLJ10545; CENP-Q; C6orf139; chromosome 6 open reading frame 139 |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CENPQ and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CENPQ |
Name | centromere protein Q |
Aliases | FLJ10545; CENP-Q; C6orf139; chromosome 6 open reading frame 139 |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CENPQ in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | CENPQ |
Name | centromere protein Q |
Aliases | FLJ10545; CENP-Q; C6orf139; chromosome 6 open reading frame 139 |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CENPQ in various data sets.
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Points in the above scatter plot represent the mutation difference of CENPQ in various data sets.
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Summary | |
---|---|
Symbol | CENPQ |
Name | centromere protein Q |
Aliases | FLJ10545; CENP-Q; C6orf139; chromosome 6 open reading frame 139 |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CENPQ. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CENPQ |
Name | centromere protein Q |
Aliases | FLJ10545; CENP-Q; C6orf139; chromosome 6 open reading frame 139 |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CENPQ. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CENPQ. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CENPQ |
Name | centromere protein Q |
Aliases | FLJ10545; CENP-Q; C6orf139; chromosome 6 open reading frame 139 |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CENPQ. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CENPQ |
Name | centromere protein Q |
Aliases | FLJ10545; CENP-Q; C6orf139; chromosome 6 open reading frame 139 |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CENPQ expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CENPQ |
Name | centromere protein Q |
Aliases | FLJ10545; CENP-Q; C6orf139; chromosome 6 open reading frame 139 |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CENPQ and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |