Summary | |
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Symbol | CETN1 |
Name | centrin, EF-hand protein, 1 |
Aliases | CEN1; CETN; caltractin; Caltractin isoform 2; Centrin-1 |
Chromosomal Location | 18p11.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Centrosome of interphase and mitotic cells. |
Domain |
PF13499 EF-hand domain pair PF13833 EF-hand domain pair |
Function |
Plays a fundamental role in microtubule-organizing center structure and function (PubMed:8175926). Plays a role in sperm cilia formation (By similarity). |
Biological Process |
GO:0007067 mitotic nuclear division GO:0009266 response to temperature stimulus GO:0009408 response to heat GO:0034605 cellular response to heat |
Molecular Function |
GO:0008017 microtubule binding GO:0015631 tubulin binding GO:0031683 G-protein beta/gamma-subunit complex binding GO:0032795 heterotrimeric G-protein binding |
Cellular Component |
GO:0000922 spindle pole GO:0005813 centrosome GO:0005814 centriole GO:0005819 spindle GO:0005929 cilium GO:0031513 nonmotile primary cilium GO:0032391 photoreceptor connecting cilium GO:0044450 microtubule organizing center part GO:0072372 primary cilium |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | CETN1 |
Name | centrin, EF-hand protein, 1 |
Aliases | CEN1; CETN; caltractin; Caltractin isoform 2; Centrin-1 |
Chromosomal Location | 18p11.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CETN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CETN1 |
Name | centrin, EF-hand protein, 1 |
Aliases | CEN1; CETN; caltractin; Caltractin isoform 2; Centrin-1 |
Chromosomal Location | 18p11.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CETN1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CETN1 |
Name | centrin, EF-hand protein, 1 |
Aliases | CEN1; CETN; caltractin; Caltractin isoform 2; Centrin-1 |
Chromosomal Location | 18p11.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CETN1 in various data sets.
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Points in the above scatter plot represent the mutation difference of CETN1 in various data sets.
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Summary | |
---|---|
Symbol | CETN1 |
Name | centrin, EF-hand protein, 1 |
Aliases | CEN1; CETN; caltractin; Caltractin isoform 2; Centrin-1 |
Chromosomal Location | 18p11.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CETN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CETN1 |
Name | centrin, EF-hand protein, 1 |
Aliases | CEN1; CETN; caltractin; Caltractin isoform 2; Centrin-1 |
Chromosomal Location | 18p11.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CETN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CETN1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CETN1 |
Name | centrin, EF-hand protein, 1 |
Aliases | CEN1; CETN; caltractin; Caltractin isoform 2; Centrin-1 |
Chromosomal Location | 18p11.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CETN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CETN1 |
Name | centrin, EF-hand protein, 1 |
Aliases | CEN1; CETN; caltractin; Caltractin isoform 2; Centrin-1 |
Chromosomal Location | 18p11.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CETN1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CETN1 |
Name | centrin, EF-hand protein, 1 |
Aliases | CEN1; CETN; caltractin; Caltractin isoform 2; Centrin-1 |
Chromosomal Location | 18p11.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CETN1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |