Summary | |
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Symbol | CGA |
Name | glycoprotein hormones, alpha polypeptide |
Aliases | GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ...... |
Chromosomal Location | 6q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00236 Glycoprotein hormone |
Function |
- |
Biological Process |
GO:0010817 regulation of hormone levels GO:0016485 protein processing GO:0016486 peptide hormone processing GO:0030335 positive regulation of cell migration GO:0040017 positive regulation of locomotion GO:0042445 hormone metabolic process GO:0051272 positive regulation of cellular component movement GO:0051604 protein maturation GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0005179 hormone activity |
Cellular Component |
GO:0005796 Golgi lumen |
KEGG |
hsa04080 Neuroactive ligand-receptor interaction hsa04912 GnRH signaling pathway hsa04913 Ovarian steroidogenesis hsa04917 Prolactin signaling pathway hsa04918 Thyroid hormone synthesis |
Reactome |
R-HSA-209776: Amine-derived hormones R-HSA-193048: Androgen biosynthesis R-HSA-446203: Asparagine N-linked glycosylation R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418555: G alpha (s) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-209822: Glycoprotein hormones R-HSA-375281: Hormone ligand-binding receptors R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-392499: Metabolism of proteins R-HSA-196071: Metabolism of steroid hormones R-HSA-193993: Mineralocorticoid biosynthesis R-HSA-975576: N-glycan antennae elongation in the medial/trans-Golgi R-HSA-209952: Peptide hormone biosynthesis R-HSA-2980736: Peptide hormone metabolism R-HSA-597592: Post-translational protein modification R-HSA-975578: Reactions specific to the complex N-glycan synthesis pathway R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-209943: Steroid hormones R-HSA-8866910: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-209968: Thyroxine biosynthesis R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-948021: Transport to the Golgi and subsequent modification |
Summary | |
---|---|
Symbol | CGA |
Name | glycoprotein hormones, alpha polypeptide |
Aliases | GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ...... |
Chromosomal Location | 6q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CGA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CGA and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CGA |
Name | glycoprotein hormones, alpha polypeptide |
Aliases | GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ...... |
Chromosomal Location | 6q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CGA in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CGA |
Name | glycoprotein hormones, alpha polypeptide |
Aliases | GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ...... |
Chromosomal Location | 6q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CGA in various data sets.
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There is no record. |
Summary | |
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Symbol | CGA |
Name | glycoprotein hormones, alpha polypeptide |
Aliases | GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ...... |
Chromosomal Location | 6q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CGA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CGA |
Name | glycoprotein hormones, alpha polypeptide |
Aliases | GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ...... |
Chromosomal Location | 6q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CGA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CGA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CGA |
Name | glycoprotein hormones, alpha polypeptide |
Aliases | GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ...... |
Chromosomal Location | 6q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CGA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CGA |
Name | glycoprotein hormones, alpha polypeptide |
Aliases | GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ...... |
Chromosomal Location | 6q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CGA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CGA |
Name | glycoprotein hormones, alpha polypeptide |
Aliases | GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ...... |
Chromosomal Location | 6q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CGA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CGA |
Name | glycoprotein hormones, alpha polypeptide |
Aliases | GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ...... |
Chromosomal Location | 6q14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CGA collected from DrugBank database. |
There is no record. |