Summary | |
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Symbol | CGN |
Name | cingulin |
Aliases | KIAA1319 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell junction, tight junction Note=Localizes to the apical junction complex composed of tight and adherens junctions. |
Domain |
PF01576 Myosin tail |
Function |
Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. |
Biological Process |
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus |
Molecular Function |
GO:0003774 motor activity GO:0003779 actin binding GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005913 cell-cell adherens junction GO:0005923 bicellular tight junction GO:0015629 actin cytoskeleton GO:0016459 myosin complex GO:0043296 apical junction complex GO:0070160 occluding junction |
KEGG |
hsa04530 Tight junction |
Reactome |
R-HSA-162582: Signal Transduction R-HSA-170834: Signaling by TGF-beta Receptor Complex R-HSA-2173791: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
Summary | |
---|---|
Symbol | CGN |
Name | cingulin |
Aliases | KIAA1319 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CGN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CGN |
Name | cingulin |
Aliases | KIAA1319 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CGN in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | CGN |
Name | cingulin |
Aliases | KIAA1319 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CGN in various data sets.
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Points in the above scatter plot represent the mutation difference of CGN in various data sets.
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Summary | |
---|---|
Symbol | CGN |
Name | cingulin |
Aliases | KIAA1319 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CGN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CGN |
Name | cingulin |
Aliases | KIAA1319 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CGN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CGN. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CGN |
Name | cingulin |
Aliases | KIAA1319 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CGN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CGN |
Name | cingulin |
Aliases | KIAA1319 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CGN expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CGN |
Name | cingulin |
Aliases | KIAA1319 |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CGN and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |