TISIDB

Summary
Symbol	CHAMP1
Name	chromosome alignment maintaining phosphoprotein 1
Aliases	chromosome alignment-maintaining phosphoprotein; C13orf8; ZNF828; chromosome 13 open reading frame 8; zinc f ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus Chromosome Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle
Domain	-
Function	Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore.

> Gene Ontology [ TOP ]
Biological Process	GO:0000070 mitotic sister chromatid segregation GO:0000819 sister chromatid segregation GO:0007059 chromosome segregation GO:0007067 mitotic nuclear division GO:0007080 mitotic metaphase plate congression GO:0008608 attachment of spindle microtubules to kinetochore GO:0031134 sister chromatid biorientation GO:0034501 protein localization to kinetochore GO:0034502 protein localization to chromosome GO:0035372 protein localization to microtubule GO:0044380 protein localization to cytoskeleton GO:0050000 chromosome localization GO:0051303 establishment of chromosome localization GO:0051310 metaphase plate congression GO:0051315 attachment of mitotic spindle microtubules to kinetochore GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0071459 protein localization to chromosome, centromeric region GO:0072698 protein localization to microtubule cytoskeleton GO:0098813 nuclear chromosome segregation
Molecular Function	-
Cellular Component	GO:0000775 chromosome, centromeric region GO:0000776 kinetochore GO:0000777 condensed chromosome kinetochore GO:0000779 condensed chromosome, centromeric region GO:0000793 condensed chromosome GO:0005819 spindle GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	CHAMP1
Name	chromosome alignment maintaining phosphoprotein 1
Aliases	chromosome alignment-maintaining phosphoprotein; C13orf8; ZNF828; chromosome 13 open reading frame 8; zinc f ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between CHAMP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	CHAMP1
Name	chromosome alignment maintaining phosphoprotein 1
Aliases	chromosome alignment-maintaining phosphoprotein; C13orf8; ZNF828; chromosome 13 open reading frame 8; zinc f ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of CHAMP1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	CHAMP1
Name	chromosome alignment maintaining phosphoprotein 1
Aliases	chromosome alignment-maintaining phosphoprotein; C13orf8; ZNF828; chromosome 13 open reading frame 8; zinc f ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of CHAMP1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.644	0.0308
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	1.063	0.513
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.333	0.798
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.369	0.129
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.617	0.763
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.056	0.983
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.033	0.923
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.071	0.963
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.038	0.982
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.41	0.671
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.835	0.561
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.165	0.0447

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of CHAMP1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	7.4	0.0709
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	7.4	0.096
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	9.5	9.5	0.492
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	CHAMP1
Name	chromosome alignment maintaining phosphoprotein 1
Aliases	chromosome alignment-maintaining phosphoprotein; C13orf8; ZNF828; chromosome 13 open reading frame 8; zinc f ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CHAMP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	CHAMP1
Name	chromosome alignment maintaining phosphoprotein 1
Aliases	chromosome alignment-maintaining phosphoprotein; C13orf8; ZNF828; chromosome 13 open reading frame 8; zinc f ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CHAMP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CHAMP1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	CHAMP1
Name	chromosome alignment maintaining phosphoprotein 1
Aliases	chromosome alignment-maintaining phosphoprotein; C13orf8; ZNF828; chromosome 13 open reading frame 8; zinc f ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CHAMP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	CHAMP1
Name	chromosome alignment maintaining phosphoprotein 1
Aliases	chromosome alignment-maintaining phosphoprotein; C13orf8; ZNF828; chromosome 13 open reading frame 8; zinc f ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of CHAMP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	CHAMP1
Name	chromosome alignment maintaining phosphoprotein 1
Aliases	chromosome alignment-maintaining phosphoprotein; C13orf8; ZNF828; chromosome 13 open reading frame 8; zinc f ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between CHAMP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	CHAMP1
Name	chromosome alignment maintaining phosphoprotein 1
Aliases	chromosome alignment-maintaining phosphoprotein; C13orf8; ZNF828; chromosome 13 open reading frame 8; zinc f ......
Chromosomal Location	13q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting CHAMP1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse CHAMP1