Browse CHD3

Summary
SymbolCHD3
Namechromodomain helicase DNA binding protein 3
Aliases Mi-2a; ZFH; Mi2-ALPHA; ATP-dependent helicase CHD3; CHD-3; hZFH; mi-2 autoantigen 240 kDa protein; zinc-fing ......
Chromosomal Location17p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Associates with centrosomes in interphase and mitosis.
Domain PF08074 CHDCT2 (NUC038) domain
PF08073 CHDNT (NUC034) domain
PF00385 Chromo (CHRromatin Organisation MOdifier) domain
PF06461 Domain of Unknown Function (DUF1086)
PF06465 Domain of Unknown Function (DUF1087)
PF00271 Helicase conserved C-terminal domain
PF00628 PHD-finger
PF00176 SNF2 family N-terminal domain
Function

Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0006333 chromatin assembly or disassembly
GO:0006476 protein deacetylation
GO:0007051 spindle organization
GO:0016570 histone modification
GO:0016575 histone deacetylation
GO:0031023 microtubule organizing center organization
GO:0032392 DNA geometric change
GO:0032508 DNA duplex unwinding
GO:0035601 protein deacylation
GO:0051297 centrosome organization
GO:0071103 DNA conformation change
GO:0072331 signal transduction by p53 class mediator
GO:0098732 macromolecule deacylation
GO:1901796 regulation of signal transduction by p53 class mediator
Molecular Function GO:0003678 DNA helicase activity
GO:0004003 ATP-dependent DNA helicase activity
GO:0004386 helicase activity
GO:0004407 histone deacetylase activity
GO:0008026 ATP-dependent helicase activity
GO:0008094 DNA-dependent ATPase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0016887 ATPase activity
GO:0019213 deacetylase activity
GO:0033558 protein deacetylase activity
GO:0042623 ATPase activity, coupled
GO:0070035 purine NTP-dependent helicase activity
Cellular Component GO:0000118 histone deacetylase complex
GO:0005813 centrosome
GO:0016581 NuRD complex
GO:0017053 transcriptional repressor complex
GO:0045111 intermediate filament cytoskeleton
GO:0070603 SWI/SNF superfamily-type complex
GO:0090545 CHD-type complex
GO:0090568 nuclear transcriptional repressor complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3214815: HDACs deacetylate histones
R-HSA-5250913: Positive epigenetic regulation of rRNA expression
R-HSA-73854: RNA Polymerase I Promoter Clearance
R-HSA-73864: RNA Polymerase I Transcription
R-HSA-73762: RNA Polymerase I Transcription Initiation
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804758: Regulation of TP53 Activity through Acetylation
R-HSA-3700989: Transcriptional Regulation by TP53
Summary
SymbolCHD3
Namechromodomain helicase DNA binding protein 3
Aliases Mi-2a; ZFH; Mi2-ALPHA; ATP-dependent helicase CHD3; CHD-3; hZFH; mi-2 autoantigen 240 kDa protein; zinc-fing ......
Chromosomal Location17p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CHD3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCHD3
Namechromodomain helicase DNA binding protein 3
Aliases Mi-2a; ZFH; Mi2-ALPHA; ATP-dependent helicase CHD3; CHD-3; hZFH; mi-2 autoantigen 240 kDa protein; zinc-fing ......
Chromosomal Location17p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CHD3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCHD3
Namechromodomain helicase DNA binding protein 3
Aliases Mi-2a; ZFH; Mi2-ALPHA; ATP-dependent helicase CHD3; CHD-3; hZFH; mi-2 autoantigen 240 kDa protein; zinc-fing ......
Chromosomal Location17p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CHD3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1330.56
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3080.87
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4530.746
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0350.887
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2730.928
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2610.948
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.270.56
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2830.885
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2160.923
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.0020.508
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2530.581
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0090.91
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CHD3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.15.91.21
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414257.117.90.405
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.8113.80.73
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.813.61.21
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91633.3033.30.0365
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59400400.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.97.40.51
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.514.3-1.81
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCHD3
Namechromodomain helicase DNA binding protein 3
Aliases Mi-2a; ZFH; Mi2-ALPHA; ATP-dependent helicase CHD3; CHD-3; hZFH; mi-2 autoantigen 240 kDa protein; zinc-fing ......
Chromosomal Location17p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CHD3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCHD3
Namechromodomain helicase DNA binding protein 3
Aliases Mi-2a; ZFH; Mi2-ALPHA; ATP-dependent helicase CHD3; CHD-3; hZFH; mi-2 autoantigen 240 kDa protein; zinc-fing ......
Chromosomal Location17p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CHD3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CHD3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCHD3
Namechromodomain helicase DNA binding protein 3
Aliases Mi-2a; ZFH; Mi2-ALPHA; ATP-dependent helicase CHD3; CHD-3; hZFH; mi-2 autoantigen 240 kDa protein; zinc-fing ......
Chromosomal Location17p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CHD3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCHD3
Namechromodomain helicase DNA binding protein 3
Aliases Mi-2a; ZFH; Mi2-ALPHA; ATP-dependent helicase CHD3; CHD-3; hZFH; mi-2 autoantigen 240 kDa protein; zinc-fing ......
Chromosomal Location17p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CHD3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCHD3
Namechromodomain helicase DNA binding protein 3
Aliases Mi-2a; ZFH; Mi2-ALPHA; ATP-dependent helicase CHD3; CHD-3; hZFH; mi-2 autoantigen 240 kDa protein; zinc-fing ......
Chromosomal Location17p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CHD3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCHD3
Namechromodomain helicase DNA binding protein 3
Aliases Mi-2a; ZFH; Mi2-ALPHA; ATP-dependent helicase CHD3; CHD-3; hZFH; mi-2 autoantigen 240 kDa protein; zinc-fing ......
Chromosomal Location17p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CHD3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.