Summary | |
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Symbol | CHD8 |
Name | chromodomain helicase DNA binding protein 8 |
Aliases | KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Note=Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites. |
Domain |
PF07533 BRK domain PF00385 Chromo (CHRromatin Organisation MOdifier) domain PF00271 Helicase conserved C-terminal domain PF00176 SNF2 family N-terminal domain |
Function |
DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. |
Biological Process |
GO:0001701 in utero embryonic development GO:0006338 chromatin remodeling GO:0006359 regulation of transcription from RNA polymerase III promoter GO:0006383 transcription from RNA polymerase III promoter GO:0016055 Wnt signaling pathway GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0032392 DNA geometric change GO:0032508 DNA duplex unwinding GO:0043044 ATP-dependent chromatin remodeling GO:0044346 fibroblast apoptotic process GO:0045945 positive regulation of transcription from RNA polymerase III promoter GO:0048565 digestive tract development GO:0055123 digestive system development GO:0060070 canonical Wnt signaling pathway GO:0060828 regulation of canonical Wnt signaling pathway GO:0071103 DNA conformation change GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0198738 cell-cell signaling by wnt GO:2000269 regulation of fibroblast apoptotic process GO:2000270 negative regulation of fibroblast apoptotic process |
Molecular Function |
GO:0002039 p53 binding GO:0003678 DNA helicase activity GO:0003682 chromatin binding GO:0004386 helicase activity GO:0008013 beta-catenin binding GO:0008094 DNA-dependent ATPase activity GO:0016887 ATPase activity GO:0035064 methylated histone binding GO:0042393 histone binding GO:0042623 ATPase activity, coupled GO:0070016 armadillo repeat domain binding |
Cellular Component |
GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0044665 MLL1/2 complex GO:0071339 MLL1 complex |
KEGG |
hsa04310 Wnt signaling pathway |
Reactome |
R-HSA-3769402: Deactivation of the beta-catenin transactivating complex R-HSA-162582: Signal Transduction R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT |
Summary | |
---|---|
Symbol | CHD8 |
Name | chromodomain helicase DNA binding protein 8 |
Aliases | KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CHD8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CHD8 |
Name | chromodomain helicase DNA binding protein 8 |
Aliases | KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CHD8 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | CHD8 |
Name | chromodomain helicase DNA binding protein 8 |
Aliases | KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CHD8 in various data sets.
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Points in the above scatter plot represent the mutation difference of CHD8 in various data sets.
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Summary | |
---|---|
Symbol | CHD8 |
Name | chromodomain helicase DNA binding protein 8 |
Aliases | KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CHD8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CHD8 |
Name | chromodomain helicase DNA binding protein 8 |
Aliases | KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CHD8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CHD8. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CHD8 |
Name | chromodomain helicase DNA binding protein 8 |
Aliases | KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CHD8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CHD8 |
Name | chromodomain helicase DNA binding protein 8 |
Aliases | KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CHD8 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CHD8 |
Name | chromodomain helicase DNA binding protein 8 |
Aliases | KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CHD8 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CHD8 |
Name | chromodomain helicase DNA binding protein 8 |
Aliases | KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CHD8 collected from DrugBank database. |
There is no record. |