Summary | |
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Symbol | CHI3L1 |
Name | chitinase 3-like 1 (cartilage glycoprotein-39) |
Aliases | YKL40; ASRT7; CGP-39; GP-39; HC-gp39; HCGP-3P; YKL-40; YYL-40; hCGP-39; 39 kDa synovial protein; cartilage g ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space Cytoplasm Cytoplasm, perinuclear region Endoplasmic reticulum |
Domain |
PF00704 Glycosyl hydrolases family 18 |
Function |
Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. |
Biological Process |
GO:0001501 skeletal system development GO:0001525 angiogenesis GO:0007250 activation of NF-kappaB-inducing kinase activity GO:0009306 protein secretion GO:0009612 response to mechanical stimulus GO:0010799 regulation of peptidyl-threonine phosphorylation GO:0010800 positive regulation of peptidyl-threonine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018210 peptidyl-threonine modification GO:0030323 respiratory tube development GO:0030324 lung development GO:0032147 activation of protein kinase activity GO:0032637 interleukin-8 production GO:0033674 positive regulation of kinase activity GO:0034612 response to tumor necrosis factor GO:0038061 NIK/NF-kappaB signaling GO:0043410 positive regulation of MAPK cascade GO:0043491 protein kinase B signaling GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0045860 positive regulation of protein kinase activity GO:0048514 blood vessel morphogenesis GO:0050663 cytokine secretion GO:0051216 cartilage development GO:0051896 regulation of protein kinase B signaling GO:0051897 positive regulation of protein kinase B signaling GO:0060541 respiratory system development GO:0061448 connective tissue development GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070555 response to interleukin-1 GO:0070741 response to interleukin-6 GO:0071347 cellular response to interleukin-1 GO:0071356 cellular response to tumor necrosis factor GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072606 interleukin-8 secretion GO:1901222 regulation of NIK/NF-kappaB signaling GO:1901224 positive regulation of NIK/NF-kappaB signaling GO:1901342 regulation of vasculature development GO:1904018 positive regulation of vasculature development |
Molecular Function |
GO:0005201 extracellular matrix structural constituent GO:0008061 chitin binding GO:0030246 carbohydrate binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix |
KEGG | - |
Reactome |
R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation |
Summary | |
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Symbol | CHI3L1 |
Name | chitinase 3-like 1 (cartilage glycoprotein-39) |
Aliases | YKL40; ASRT7; CGP-39; GP-39; HC-gp39; HCGP-3P; YKL-40; YYL-40; hCGP-39; 39 kDa synovial protein; cartilage g ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CHI3L1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CHI3L1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CHI3L1 |
Name | chitinase 3-like 1 (cartilage glycoprotein-39) |
Aliases | YKL40; ASRT7; CGP-39; GP-39; HC-gp39; HCGP-3P; YKL-40; YYL-40; hCGP-39; 39 kDa synovial protein; cartilage g ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CHI3L1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CHI3L1 |
Name | chitinase 3-like 1 (cartilage glycoprotein-39) |
Aliases | YKL40; ASRT7; CGP-39; GP-39; HC-gp39; HCGP-3P; YKL-40; YYL-40; hCGP-39; 39 kDa synovial protein; cartilage g ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CHI3L1 in various data sets.
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Points in the above scatter plot represent the mutation difference of CHI3L1 in various data sets.
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Summary | |
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Symbol | CHI3L1 |
Name | chitinase 3-like 1 (cartilage glycoprotein-39) |
Aliases | YKL40; ASRT7; CGP-39; GP-39; HC-gp39; HCGP-3P; YKL-40; YYL-40; hCGP-39; 39 kDa synovial protein; cartilage g ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CHI3L1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CHI3L1 |
Name | chitinase 3-like 1 (cartilage glycoprotein-39) |
Aliases | YKL40; ASRT7; CGP-39; GP-39; HC-gp39; HCGP-3P; YKL-40; YYL-40; hCGP-39; 39 kDa synovial protein; cartilage g ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CHI3L1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CHI3L1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CHI3L1 |
Name | chitinase 3-like 1 (cartilage glycoprotein-39) |
Aliases | YKL40; ASRT7; CGP-39; GP-39; HC-gp39; HCGP-3P; YKL-40; YYL-40; hCGP-39; 39 kDa synovial protein; cartilage g ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CHI3L1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CHI3L1 |
Name | chitinase 3-like 1 (cartilage glycoprotein-39) |
Aliases | YKL40; ASRT7; CGP-39; GP-39; HC-gp39; HCGP-3P; YKL-40; YYL-40; hCGP-39; 39 kDa synovial protein; cartilage g ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CHI3L1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CHI3L1 |
Name | chitinase 3-like 1 (cartilage glycoprotein-39) |
Aliases | YKL40; ASRT7; CGP-39; GP-39; HC-gp39; HCGP-3P; YKL-40; YYL-40; hCGP-39; 39 kDa synovial protein; cartilage g ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CHI3L1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CHI3L1 |
Name | chitinase 3-like 1 (cartilage glycoprotein-39) |
Aliases | YKL40; ASRT7; CGP-39; GP-39; HC-gp39; HCGP-3P; YKL-40; YYL-40; hCGP-39; 39 kDa synovial protein; cartilage g ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CHI3L1 collected from DrugBank database. |
There is no record. |