Summary | |
---|---|
Symbol | CHMP4A |
Name | charged multivesicular body protein 4A |
Aliases | HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasmic vesicle membrane. Late endosome membrane Peripheral membrane protein Note=Membrane-associated. Localizes to large vesicle-like structures. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body. |
Domain |
PF03357 Snf7 |
Function |
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). |
Biological Process |
GO:0000045 autophagosome assembly GO:0000070 mitotic sister chromatid segregation GO:0000819 sister chromatid segregation GO:0000920 cell separation after cytokinesis GO:0006612 protein targeting to membrane GO:0006620 posttranslational protein targeting to membrane GO:0006900 membrane budding GO:0006914 autophagy GO:0006997 nucleus organization GO:0007009 plasma membrane organization GO:0007032 endosome organization GO:0007033 vacuole organization GO:0007034 vacuolar transport GO:0007059 chromosome segregation GO:0007067 mitotic nuclear division GO:0007080 mitotic metaphase plate congression GO:0010324 membrane invagination GO:0010506 regulation of autophagy GO:0010507 negative regulation of autophagy GO:0010639 negative regulation of organelle organization GO:0016050 vesicle organization GO:0016197 endosomal transport GO:0016236 macroautophagy GO:0016241 regulation of macroautophagy GO:0016242 negative regulation of macroautophagy GO:0019058 viral life cycle GO:0019068 virion assembly GO:0036257 multivesicular body organization GO:0036258 multivesicular body assembly GO:0039702 viral budding via host ESCRT complex GO:0044088 regulation of vacuole organization GO:0044803 multi-organism membrane organization GO:0045047 protein targeting to ER GO:0046755 viral budding GO:0050000 chromosome localization GO:0051258 protein polymerization GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051303 establishment of chromosome localization GO:0051310 metaphase plate congression GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0070972 protein localization to endoplasmic reticulum GO:0070997 neuron death GO:0072599 establishment of protein localization to endoplasmic reticulum GO:0072657 protein localization to membrane GO:0090150 establishment of protein localization to membrane GO:0097320 membrane tubulation GO:0098813 nuclear chromosome segregation GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1902115 regulation of organelle assembly GO:1902116 negative regulation of organelle assembly GO:1902590 multi-organism organelle organization GO:1902592 multi-organism membrane budding GO:1902902 negative regulation of autophagosome assembly GO:1905037 autophagosome organization GO:2000785 regulation of autophagosome assembly |
Molecular Function |
GO:0051117 ATPase binding |
Cellular Component |
GO:0000815 ESCRT III complex GO:0005770 late endosome GO:0009898 cytoplasmic side of plasma membrane GO:0010008 endosome membrane GO:0030117 membrane coat GO:0030496 midbody GO:0030659 cytoplasmic vesicle membrane GO:0031902 late endosome membrane GO:0036452 ESCRT complex GO:0044440 endosomal part GO:0048475 coated membrane GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane |
KEGG |
hsa04144 Endocytosis |
Reactome |
R-HSA-162588: Budding and maturation of HIV virion R-HSA-2262752: Cellular responses to stress R-HSA-1643685: Disease R-HSA-917729: Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-162906: HIV Infection R-HSA-162587: HIV Life Cycle R-HSA-5663205: Infectious disease R-HSA-162599: Late Phase of HIV Life Cycle R-HSA-1632852: Macroautophagy R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | CHMP4A |
Name | charged multivesicular body protein 4A |
Aliases | HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CHMP4A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CHMP4A |
Name | charged multivesicular body protein 4A |
Aliases | HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of CHMP4A in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | CHMP4A |
Name | charged multivesicular body protein 4A |
Aliases | HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CHMP4A in various data sets.
|
There is no record. |
Summary | |
---|---|
Symbol | CHMP4A |
Name | charged multivesicular body protein 4A |
Aliases | HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CHMP4A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CHMP4A |
Name | charged multivesicular body protein 4A |
Aliases | HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CHMP4A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CHMP4A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CHMP4A |
Name | charged multivesicular body protein 4A |
Aliases | HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CHMP4A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CHMP4A |
Name | charged multivesicular body protein 4A |
Aliases | HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CHMP4A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CHMP4A |
Name | charged multivesicular body protein 4A |
Aliases | HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CHMP4A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CHMP4A |
Name | charged multivesicular body protein 4A |
Aliases | HSPC134; VPS32A; C14orf123; chromosome 14 open reading frame 123; chromatin modifying protein 4A; CHMP4; SHA ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CHMP4A collected from DrugBank database. |
There is no record. |