Summary | |
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Symbol | CHN1 |
Name | chimerin 1 |
Aliases | ARHGAP2; n-chimerin; Chimerin 1 (GTPase-activating protein, rho, 2); chimaerin 1; DURS2; Duane retraction sy ...... |
Chromosomal Location | 2q31-q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) PF00620 RhoGAP domain PF00017 SH2 domain |
Function |
GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. |
Biological Process |
GO:0007409 axonogenesis GO:0007411 axon guidance GO:0008045 motor neuron axon guidance GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010975 regulation of neuron projection development GO:0022604 regulation of cell morphogenesis GO:0048013 ephrin receptor signaling pathway GO:0048667 cell morphogenesis involved in neuron differentiation GO:0050770 regulation of axonogenesis GO:0051056 regulation of small GTPase mediated signal transduction GO:0061564 axon development GO:0097485 neuron projection guidance |
Molecular Function |
GO:0005070 SH3/SH2 adaptor activity GO:0005096 GTPase activator activity GO:0008047 enzyme activator activity GO:0030674 protein binding, bridging GO:0030695 GTPase regulator activity GO:0035591 signaling adaptor activity GO:0046875 ephrin receptor binding GO:0060090 binding, bridging GO:0060589 nucleoside-triphosphatase regulator activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-194840: Rho GTPase cycle R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases |
Summary | |
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Symbol | CHN1 |
Name | chimerin 1 |
Aliases | ARHGAP2; n-chimerin; Chimerin 1 (GTPase-activating protein, rho, 2); chimaerin 1; DURS2; Duane retraction sy ...... |
Chromosomal Location | 2q31-q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CHN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | CHN1 |
Name | chimerin 1 |
Aliases | ARHGAP2; n-chimerin; Chimerin 1 (GTPase-activating protein, rho, 2); chimaerin 1; DURS2; Duane retraction sy ...... |
Chromosomal Location | 2q31-q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CHN1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CHN1 |
Name | chimerin 1 |
Aliases | ARHGAP2; n-chimerin; Chimerin 1 (GTPase-activating protein, rho, 2); chimaerin 1; DURS2; Duane retraction sy ...... |
Chromosomal Location | 2q31-q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CHN1 in various data sets.
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Points in the above scatter plot represent the mutation difference of CHN1 in various data sets.
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Summary | |
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Symbol | CHN1 |
Name | chimerin 1 |
Aliases | ARHGAP2; n-chimerin; Chimerin 1 (GTPase-activating protein, rho, 2); chimaerin 1; DURS2; Duane retraction sy ...... |
Chromosomal Location | 2q31-q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CHN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CHN1 |
Name | chimerin 1 |
Aliases | ARHGAP2; n-chimerin; Chimerin 1 (GTPase-activating protein, rho, 2); chimaerin 1; DURS2; Duane retraction sy ...... |
Chromosomal Location | 2q31-q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CHN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CHN1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CHN1 |
Name | chimerin 1 |
Aliases | ARHGAP2; n-chimerin; Chimerin 1 (GTPase-activating protein, rho, 2); chimaerin 1; DURS2; Duane retraction sy ...... |
Chromosomal Location | 2q31-q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CHN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CHN1 |
Name | chimerin 1 |
Aliases | ARHGAP2; n-chimerin; Chimerin 1 (GTPase-activating protein, rho, 2); chimaerin 1; DURS2; Duane retraction sy ...... |
Chromosomal Location | 2q31-q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CHN1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CHN1 |
Name | chimerin 1 |
Aliases | ARHGAP2; n-chimerin; Chimerin 1 (GTPase-activating protein, rho, 2); chimaerin 1; DURS2; Duane retraction sy ...... |
Chromosomal Location | 2q31-q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CHN1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CHN1 |
Name | chimerin 1 |
Aliases | ARHGAP2; n-chimerin; Chimerin 1 (GTPase-activating protein, rho, 2); chimaerin 1; DURS2; Duane retraction sy ...... |
Chromosomal Location | 2q31-q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CHN1 collected from DrugBank database. |
There is no record. |