Summary | |
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Symbol | CHRAC1 |
Name | chromatin accessibility complex 1 |
Aliases | CHRAC15; YCL1; histone-fold protein CHRAC15; CHARC1; CHARC15; CHRAC-1; CHRAC-155; DNA polymerase epsilon sub ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00808 Histone-like transcription factor (CBF/NF-Y) and archaeal histone |
Function |
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. |
Biological Process |
GO:0006338 chromatin remodeling GO:0071897 DNA biosynthetic process |
Molecular Function |
GO:0003887 DNA-directed DNA polymerase activity GO:0016779 nucleotidyltransferase activity GO:0034061 DNA polymerase activity GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0000109 nucleotide-excision repair complex GO:0005657 replication fork GO:0008622 epsilon DNA polymerase complex GO:0008623 CHRAC GO:0030894 replisome GO:0031010 ISWI-type complex GO:0032993 protein-DNA complex GO:0042575 DNA polymerase complex GO:0043596 nuclear replication fork GO:0043601 nuclear replisome GO:0044454 nuclear chromosome part GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0070603 SWI/SNF superfamily-type complex GO:1990391 DNA repair complex |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | CHRAC1 |
Name | chromatin accessibility complex 1 |
Aliases | CHRAC15; YCL1; histone-fold protein CHRAC15; CHARC1; CHARC15; CHRAC-1; CHRAC-155; DNA polymerase epsilon sub ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CHRAC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CHRAC1 |
Name | chromatin accessibility complex 1 |
Aliases | CHRAC15; YCL1; histone-fold protein CHRAC15; CHARC1; CHARC15; CHRAC-1; CHRAC-155; DNA polymerase epsilon sub ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CHRAC1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CHRAC1 |
Name | chromatin accessibility complex 1 |
Aliases | CHRAC15; YCL1; histone-fold protein CHRAC15; CHARC1; CHARC15; CHRAC-1; CHRAC-155; DNA polymerase epsilon sub ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CHRAC1 in various data sets.
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Points in the above scatter plot represent the mutation difference of CHRAC1 in various data sets.
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Summary | |
---|---|
Symbol | CHRAC1 |
Name | chromatin accessibility complex 1 |
Aliases | CHRAC15; YCL1; histone-fold protein CHRAC15; CHARC1; CHARC15; CHRAC-1; CHRAC-155; DNA polymerase epsilon sub ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CHRAC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CHRAC1 |
Name | chromatin accessibility complex 1 |
Aliases | CHRAC15; YCL1; histone-fold protein CHRAC15; CHARC1; CHARC15; CHRAC-1; CHRAC-155; DNA polymerase epsilon sub ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CHRAC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CHRAC1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CHRAC1 |
Name | chromatin accessibility complex 1 |
Aliases | CHRAC15; YCL1; histone-fold protein CHRAC15; CHARC1; CHARC15; CHRAC-1; CHRAC-155; DNA polymerase epsilon sub ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CHRAC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CHRAC1 |
Name | chromatin accessibility complex 1 |
Aliases | CHRAC15; YCL1; histone-fold protein CHRAC15; CHARC1; CHARC15; CHRAC-1; CHRAC-155; DNA polymerase epsilon sub ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CHRAC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CHRAC1 |
Name | chromatin accessibility complex 1 |
Aliases | CHRAC15; YCL1; histone-fold protein CHRAC15; CHARC1; CHARC15; CHRAC-1; CHRAC-155; DNA polymerase epsilon sub ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CHRAC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CHRAC1 |
Name | chromatin accessibility complex 1 |
Aliases | CHRAC15; YCL1; histone-fold protein CHRAC15; CHARC1; CHARC15; CHRAC-1; CHRAC-155; DNA polymerase epsilon sub ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CHRAC1 collected from DrugBank database. |
There is no record. |