Summary | |
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Symbol | CHRNB2 |
Name | cholinergic receptor, nicotinic, beta 2 (neuronal) |
Aliases | acetylcholine receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (n ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
Domain |
PF02931 Neurotransmitter-gated ion-channel ligand binding domain PF02932 Neurotransmitter-gated ion-channel transmembrane region |
Function |
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. |
Biological Process |
GO:0001508 action potential GO:0001661 conditioned taste aversion GO:0001666 response to hypoxia GO:0001963 synaptic transmission, dopaminergic GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0003012 muscle system process GO:0003014 renal system process GO:0006584 catecholamine metabolic process GO:0006816 calcium ion transport GO:0006936 muscle contraction GO:0006939 smooth muscle contraction GO:0007270 neuron-neuron synaptic transmission GO:0007271 synaptic transmission, cholinergic GO:0007274 neuromuscular synaptic transmission GO:0007409 axonogenesis GO:0007416 synapse assembly GO:0007588 excretion GO:0007601 visual perception GO:0007605 sensory perception of sound GO:0007611 learning or memory GO:0007612 learning GO:0007613 memory GO:0007622 rhythmic behavior GO:0007623 circadian rhythm GO:0007626 locomotory behavior GO:0007631 feeding behavior GO:0007632 visual behavior GO:0008306 associative learning GO:0008542 visual learning GO:0009308 amine metabolic process GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0009712 catechol-containing compound metabolic process GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010975 regulation of neuron projection development GO:0014046 dopamine secretion GO:0014059 regulation of dopamine secretion GO:0015837 amine transport GO:0015844 monoamine transport GO:0015850 organic hydroxy compound transport GO:0015872 dopamine transport GO:0016358 dendrite development GO:0018958 phenol-containing compound metabolic process GO:0019233 sensory perception of pain GO:0021536 diencephalon development GO:0021545 cranial nerve development GO:0021554 optic nerve development GO:0021562 vestibulocochlear nerve development GO:0021602 cranial nerve morphogenesis GO:0021631 optic nerve morphogenesis GO:0021675 nerve development GO:0021771 lateral geniculate nucleus development GO:0021794 thalamus development GO:0021952 central nervous system projection neuron axonogenesis GO:0021953 central nervous system neuron differentiation GO:0021954 central nervous system neuron development GO:0021955 central nervous system neuron axonogenesis GO:0022410 circadian sleep/wake cycle process GO:0022604 regulation of cell morphogenesis GO:0030431 sleep GO:0030534 adult behavior GO:0030888 regulation of B cell proliferation GO:0030890 positive regulation of B cell proliferation GO:0030900 forebrain development GO:0032225 regulation of synaptic transmission, dopaminergic GO:0032226 positive regulation of synaptic transmission, dopaminergic GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033238 regulation of cellular amine metabolic process GO:0033603 positive regulation of dopamine secretion GO:0033605 positive regulation of catecholamine secretion GO:0035094 response to nicotine GO:0035095 behavioral response to nicotine GO:0035176 social behavior GO:0036293 response to decreased oxygen levels GO:0042053 regulation of dopamine metabolic process GO:0042069 regulation of catecholamine metabolic process GO:0042100 B cell proliferation GO:0042113 B cell activation GO:0042220 response to cocaine GO:0042320 regulation of circadian sleep/wake cycle, REM sleep GO:0042391 regulation of membrane potential GO:0042417 dopamine metabolic process GO:0042745 circadian sleep/wake cycle GO:0042747 circadian sleep/wake cycle, REM sleep GO:0042748 circadian sleep/wake cycle, non-REM sleep GO:0042749 regulation of circadian sleep/wake cycle GO:0042752 regulation of circadian rhythm GO:0043279 response to alkaloid GO:0044106 cellular amine metabolic process GO:0044708 single-organism behavior GO:0045187 regulation of circadian sleep/wake cycle, sleep GO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep GO:0045471 response to ethanol GO:0045759 negative regulation of action potential GO:0046651 lymphocyte proliferation GO:0048511 rhythmic process GO:0048512 circadian behavior GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048813 dendrite morphogenesis GO:0048814 regulation of dendrite morphogenesis GO:0048857 neural nucleus development GO:0050432 catecholamine secretion GO:0050433 regulation of catecholamine secretion GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050773 regulation of dendrite development GO:0050795 regulation of behavior GO:0050802 circadian sleep/wake cycle, sleep GO:0050803 regulation of synapse structure or activity GO:0050804 modulation of synaptic transmission GO:0050806 positive regulation of synaptic transmission GO:0050807 regulation of synapse organization GO:0050808 synapse organization GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050871 positive regulation of B cell activation GO:0050890 cognition GO:0050953 sensory perception of light stimulus GO:0050954 sensory perception of mechanical stimulus GO:0051047 positive regulation of secretion GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051259 protein oligomerization GO:0051291 protein heterooligomerization GO:0051703 intraspecies interaction between organisms GO:0051705 multi-organism behavior GO:0051899 membrane depolarization GO:0051937 catecholamine transport GO:0051952 regulation of amine transport GO:0051954 positive regulation of amine transport GO:0051963 regulation of synapse assembly GO:0060073 micturition GO:0060084 synaptic transmission involved in micturition GO:0061564 axon development GO:0070482 response to oxygen levels GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0070838 divalent metal ion transport GO:0072511 divalent inorganic cation transport GO:0097305 response to alcohol GO:0098900 regulation of action potential GO:1901615 organic hydroxy compound metabolic process GO:1903532 positive regulation of secretion by cell |
Molecular Function |
GO:0004889 acetylcholine-activated cation-selective channel activity GO:0005216 ion channel activity GO:0005230 extracellular ligand-gated ion channel activity GO:0005231 excitatory extracellular ligand-gated ion channel activity GO:0005261 cation channel activity GO:0008144 drug binding GO:0015267 channel activity GO:0015276 ligand-gated ion channel activity GO:0015464 acetylcholine receptor activity GO:0022803 passive transmembrane transporter activity GO:0022834 ligand-gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity GO:0030594 neurotransmitter receptor activity GO:0042165 neurotransmitter binding GO:0042166 acetylcholine binding GO:0046982 protein heterodimerization activity GO:0070405 ammonium ion binding |
Cellular Component |
GO:0005892 acetylcholine-gated channel complex GO:0009897 external side of plasma membrane GO:0034702 ion channel complex GO:0043235 receptor complex GO:0045211 postsynaptic membrane GO:0097060 synaptic membrane GO:0098552 side of membrane GO:0098794 postsynapse GO:0098802 plasma membrane receptor complex GO:1902495 transmembrane transporter complex GO:1990351 transporter complex |
KEGG |
hsa04080 Neuroactive ligand-receptor interaction hsa04725 Cholinergic synapse |
Reactome |
R-HSA-181431: Acetylcholine Binding And Downstream Events R-HSA-629602: Activation of Nicotinic Acetylcholine Receptors R-HSA-629597: Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629594: Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629587: Highly sodium permeable acetylcholine nicotinic receptors R-HSA-112316: Neuronal System R-HSA-112314: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-622327: Postsynaptic nicotinic acetylcholine receptors R-HSA-622323: Presynaptic nicotinic acetylcholine receptors R-HSA-112315: Transmission across Chemical Synapses |
Summary | |
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Symbol | CHRNB2 |
Name | cholinergic receptor, nicotinic, beta 2 (neuronal) |
Aliases | acetylcholine receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (n ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CHRNB2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | CHRNB2 |
Name | cholinergic receptor, nicotinic, beta 2 (neuronal) |
Aliases | acetylcholine receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (n ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CHRNB2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CHRNB2 |
Name | cholinergic receptor, nicotinic, beta 2 (neuronal) |
Aliases | acetylcholine receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (n ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CHRNB2 in various data sets.
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Points in the above scatter plot represent the mutation difference of CHRNB2 in various data sets.
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Summary | |
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Symbol | CHRNB2 |
Name | cholinergic receptor, nicotinic, beta 2 (neuronal) |
Aliases | acetylcholine receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (n ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CHRNB2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CHRNB2 |
Name | cholinergic receptor, nicotinic, beta 2 (neuronal) |
Aliases | acetylcholine receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (n ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CHRNB2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CHRNB2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CHRNB2 |
Name | cholinergic receptor, nicotinic, beta 2 (neuronal) |
Aliases | acetylcholine receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (n ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CHRNB2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CHRNB2 |
Name | cholinergic receptor, nicotinic, beta 2 (neuronal) |
Aliases | acetylcholine receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (n ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CHRNB2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CHRNB2 |
Name | cholinergic receptor, nicotinic, beta 2 (neuronal) |
Aliases | acetylcholine receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (n ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CHRNB2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CHRNB2 |
Name | cholinergic receptor, nicotinic, beta 2 (neuronal) |
Aliases | acetylcholine receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (n ...... |
Chromosomal Location | 1q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CHRNB2 collected from DrugBank database. |
Details on drugs targeting CHRNB2.
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