Summary | |
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Symbol | CHST6 |
Name | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
Aliases | MCDC1; C-GlcNAc6ST; GST4-beta; N-acetylglucosamine 6-O-sulfotransferase 5; corneal N-acetylglucosamine 6-sul ...... |
Chromosomal Location | 16q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus membrane Single-pass type II membrane protein |
Domain |
PF00685 Sulfotransferase domain |
Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N-acetyllactosamine structures. |
Biological Process |
GO:0006022 aminoglycan metabolic process GO:0006023 aminoglycan biosynthetic process GO:0006024 glycosaminoglycan biosynthetic process GO:0006040 amino sugar metabolic process GO:0006044 N-acetylglucosamine metabolic process GO:0006790 sulfur compound metabolic process GO:0018146 keratan sulfate biosynthetic process GO:0030203 glycosaminoglycan metabolic process GO:0042339 keratan sulfate metabolic process GO:0044272 sulfur compound biosynthetic process GO:1901071 glucosamine-containing compound metabolic process GO:1903510 mucopolysaccharide metabolic process |
Molecular Function |
GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity GO:0008146 sulfotransferase activity GO:0016782 transferase activity, transferring sulfur-containing groups |
Cellular Component | - |
KEGG |
hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate |
Reactome |
R-HSA-1630316: Glycosaminoglycan metabolism R-HSA-2022854: Keratan sulfate biosynthesis R-HSA-1638074: Keratan sulfate/keratin metabolism R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates |
Summary | |
---|---|
Symbol | CHST6 |
Name | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
Aliases | MCDC1; C-GlcNAc6ST; GST4-beta; N-acetylglucosamine 6-O-sulfotransferase 5; corneal N-acetylglucosamine 6-sul ...... |
Chromosomal Location | 16q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CHST6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CHST6 |
Name | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
Aliases | MCDC1; C-GlcNAc6ST; GST4-beta; N-acetylglucosamine 6-O-sulfotransferase 5; corneal N-acetylglucosamine 6-sul ...... |
Chromosomal Location | 16q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CHST6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CHST6 |
Name | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
Aliases | MCDC1; C-GlcNAc6ST; GST4-beta; N-acetylglucosamine 6-O-sulfotransferase 5; corneal N-acetylglucosamine 6-sul ...... |
Chromosomal Location | 16q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CHST6 in various data sets.
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Points in the above scatter plot represent the mutation difference of CHST6 in various data sets.
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Summary | |
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Symbol | CHST6 |
Name | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
Aliases | MCDC1; C-GlcNAc6ST; GST4-beta; N-acetylglucosamine 6-O-sulfotransferase 5; corneal N-acetylglucosamine 6-sul ...... |
Chromosomal Location | 16q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CHST6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CHST6 |
Name | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
Aliases | MCDC1; C-GlcNAc6ST; GST4-beta; N-acetylglucosamine 6-O-sulfotransferase 5; corneal N-acetylglucosamine 6-sul ...... |
Chromosomal Location | 16q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CHST6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CHST6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CHST6 |
Name | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
Aliases | MCDC1; C-GlcNAc6ST; GST4-beta; N-acetylglucosamine 6-O-sulfotransferase 5; corneal N-acetylglucosamine 6-sul ...... |
Chromosomal Location | 16q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CHST6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CHST6 |
Name | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
Aliases | MCDC1; C-GlcNAc6ST; GST4-beta; N-acetylglucosamine 6-O-sulfotransferase 5; corneal N-acetylglucosamine 6-sul ...... |
Chromosomal Location | 16q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CHST6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CHST6 |
Name | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
Aliases | MCDC1; C-GlcNAc6ST; GST4-beta; N-acetylglucosamine 6-O-sulfotransferase 5; corneal N-acetylglucosamine 6-sul ...... |
Chromosomal Location | 16q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CHST6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CHST6 |
Name | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
Aliases | MCDC1; C-GlcNAc6ST; GST4-beta; N-acetylglucosamine 6-O-sulfotransferase 5; corneal N-acetylglucosamine 6-sul ...... |
Chromosomal Location | 16q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CHST6 collected from DrugBank database. |
There is no record. |