Summary | |
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Symbol | CIC |
Name | capicua transcriptional repressor |
Aliases | KIAA0306; capicua (Drosophila) homolog; capicua homolog (Drosophila) |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00505 HMG (high mobility group) box |
Function |
Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. |
Biological Process |
GO:0030323 respiratory tube development GO:0030324 lung development GO:0048286 lung alveolus development GO:0060541 respiratory system development |
Molecular Function |
GO:0003682 chromatin binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | CIC |
Name | capicua transcriptional repressor |
Aliases | KIAA0306; capicua (Drosophila) homolog; capicua homolog (Drosophila) |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CIC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CIC |
Name | capicua transcriptional repressor |
Aliases | KIAA0306; capicua (Drosophila) homolog; capicua homolog (Drosophila) |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CIC in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CIC |
Name | capicua transcriptional repressor |
Aliases | KIAA0306; capicua (Drosophila) homolog; capicua homolog (Drosophila) |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CIC in various data sets.
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Points in the above scatter plot represent the mutation difference of CIC in various data sets.
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Summary | |
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Symbol | CIC |
Name | capicua transcriptional repressor |
Aliases | KIAA0306; capicua (Drosophila) homolog; capicua homolog (Drosophila) |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CIC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CIC |
Name | capicua transcriptional repressor |
Aliases | KIAA0306; capicua (Drosophila) homolog; capicua homolog (Drosophila) |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CIC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CIC. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CIC |
Name | capicua transcriptional repressor |
Aliases | KIAA0306; capicua (Drosophila) homolog; capicua homolog (Drosophila) |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CIC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CIC |
Name | capicua transcriptional repressor |
Aliases | KIAA0306; capicua (Drosophila) homolog; capicua homolog (Drosophila) |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CIC expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CIC |
Name | capicua transcriptional repressor |
Aliases | KIAA0306; capicua (Drosophila) homolog; capicua homolog (Drosophila) |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CIC and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |