Summary | |
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Symbol | CIDEC |
Name | cell death-inducing DFFA-like effector c |
Aliases | CIDE-3; FLJ20871; Fsp27; CIDE3; FPLD5; fat specific protein 27; Fat-specific protein FSP27 homolog; Cell dea ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Endoplasmic reticulum. Lipid droplet. Note=Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites. |
Domain |
PF02017 CIDE-N domain |
Function |
Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression. |
Biological Process |
GO:0034389 lipid particle organization GO:0097194 execution phase of apoptosis |
Molecular Function | - |
Cellular Component |
GO:0005811 lipid particle |
KEGG | - |
Reactome |
R-HSA-174800: Chylomicron-mediated lipid transport R-HSA-73923: Lipid digestion, mobilization, and transport R-HSA-174824: Lipoprotein metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins |
Summary | |
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Symbol | CIDEC |
Name | cell death-inducing DFFA-like effector c |
Aliases | CIDE-3; FLJ20871; Fsp27; CIDE3; FPLD5; fat specific protein 27; Fat-specific protein FSP27 homolog; Cell dea ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CIDEC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CIDEC |
Name | cell death-inducing DFFA-like effector c |
Aliases | CIDE-3; FLJ20871; Fsp27; CIDE3; FPLD5; fat specific protein 27; Fat-specific protein FSP27 homolog; Cell dea ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CIDEC in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CIDEC |
Name | cell death-inducing DFFA-like effector c |
Aliases | CIDE-3; FLJ20871; Fsp27; CIDE3; FPLD5; fat specific protein 27; Fat-specific protein FSP27 homolog; Cell dea ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CIDEC in various data sets.
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Points in the above scatter plot represent the mutation difference of CIDEC in various data sets.
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Summary | |
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Symbol | CIDEC |
Name | cell death-inducing DFFA-like effector c |
Aliases | CIDE-3; FLJ20871; Fsp27; CIDE3; FPLD5; fat specific protein 27; Fat-specific protein FSP27 homolog; Cell dea ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CIDEC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CIDEC |
Name | cell death-inducing DFFA-like effector c |
Aliases | CIDE-3; FLJ20871; Fsp27; CIDE3; FPLD5; fat specific protein 27; Fat-specific protein FSP27 homolog; Cell dea ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CIDEC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CIDEC. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CIDEC |
Name | cell death-inducing DFFA-like effector c |
Aliases | CIDE-3; FLJ20871; Fsp27; CIDE3; FPLD5; fat specific protein 27; Fat-specific protein FSP27 homolog; Cell dea ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CIDEC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CIDEC |
Name | cell death-inducing DFFA-like effector c |
Aliases | CIDE-3; FLJ20871; Fsp27; CIDE3; FPLD5; fat specific protein 27; Fat-specific protein FSP27 homolog; Cell dea ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CIDEC expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CIDEC |
Name | cell death-inducing DFFA-like effector c |
Aliases | CIDE-3; FLJ20871; Fsp27; CIDE3; FPLD5; fat specific protein 27; Fat-specific protein FSP27 homolog; Cell dea ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CIDEC and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CIDEC |
Name | cell death-inducing DFFA-like effector c |
Aliases | CIDE-3; FLJ20871; Fsp27; CIDE3; FPLD5; fat specific protein 27; Fat-specific protein FSP27 homolog; Cell dea ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CIDEC collected from DrugBank database. |
There is no record. |