Summary | |
---|---|
Symbol | CIRBP |
Name | cold inducible RNA binding protein |
Aliases | CIRP; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; cold inducible RNA-binding prote ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus, nucleoplasm Cytoplasm Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity). |
Domain |
PF00076 RNA recognition motif. (a.k.a. RRM |
Function |
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. |
Biological Process |
GO:0006417 regulation of translation GO:0009266 response to temperature stimulus GO:0009314 response to radiation GO:0009409 response to cold GO:0009411 response to UV GO:0009416 response to light stimulus GO:0010608 posttranscriptional regulation of gene expression GO:0017148 negative regulation of translation GO:0022613 ribonucleoprotein complex biogenesis GO:0022618 ribonucleoprotein complex assembly GO:0034063 stress granule assembly GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0034250 positive regulation of cellular amide metabolic process GO:0043487 regulation of RNA stability GO:0043488 regulation of mRNA stability GO:0043489 RNA stabilization GO:0045727 positive regulation of translation GO:0048255 mRNA stabilization GO:0071826 ribonucleoprotein complex subunit organization |
Molecular Function |
GO:0003729 mRNA binding GO:0003730 mRNA 3'-UTR binding GO:0019843 rRNA binding GO:0030371 translation repressor activity GO:0045182 translation regulator activity GO:0070181 small ribosomal subunit rRNA binding |
Cellular Component |
GO:0010494 cytoplasmic stress granule GO:0035770 ribonucleoprotein granule GO:0036464 cytoplasmic ribonucleoprotein granule |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | CIRBP |
Name | cold inducible RNA binding protein |
Aliases | CIRP; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; cold inducible RNA-binding prote ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CIRBP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CIRBP and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | CIRBP |
Name | cold inducible RNA binding protein |
Aliases | CIRP; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; cold inducible RNA-binding prote ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of CIRBP in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | CIRBP |
Name | cold inducible RNA binding protein |
Aliases | CIRP; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; cold inducible RNA-binding prote ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CIRBP in various data sets.
|
Points in the above scatter plot represent the mutation difference of CIRBP in various data sets.
|
Summary | |
---|---|
Symbol | CIRBP |
Name | cold inducible RNA binding protein |
Aliases | CIRP; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; cold inducible RNA-binding prote ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CIRBP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CIRBP |
Name | cold inducible RNA binding protein |
Aliases | CIRP; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; cold inducible RNA-binding prote ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CIRBP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CIRBP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CIRBP |
Name | cold inducible RNA binding protein |
Aliases | CIRP; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; cold inducible RNA-binding prote ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CIRBP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CIRBP |
Name | cold inducible RNA binding protein |
Aliases | CIRP; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; cold inducible RNA-binding prote ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CIRBP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CIRBP |
Name | cold inducible RNA binding protein |
Aliases | CIRP; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; cold inducible RNA-binding prote ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CIRBP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CIRBP |
Name | cold inducible RNA binding protein |
Aliases | CIRP; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; cold inducible RNA-binding prote ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CIRBP collected from DrugBank database. |
There is no record. |