Browse CKS1B

Summary
SymbolCKS1B
NameCDC28 protein kinase regulatory subunit 1B
Aliases ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF01111 Cyclin-dependent kinase regulatory subunit
Function

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

> Gene Ontology
 
Biological Process GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007346 regulation of mitotic cell cycle
GO:0033674 positive regulation of kinase activity
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045787 positive regulation of cell cycle
GO:0045860 positive regulation of protein kinase activity
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:1904029 regulation of cyclin-dependent protein kinase activity
GO:1904031 positive regulation of cyclin-dependent protein kinase activity
Molecular Function GO:0008047 enzyme activator activity
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019207 kinase regulator activity
GO:0019209 kinase activator activity
GO:0019887 protein kinase regulator activity
GO:0030295 protein kinase activator activity
GO:0032182 ubiquitin-like protein binding
GO:0042393 histone binding
GO:0043130 ubiquitin binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity
Cellular Component GO:0000151 ubiquitin ligase complex
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0019005 SCF ubiquitin ligase complex
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:1902554 serine/threonine protein kinase complex
GO:1902911 protein kinase complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-69656: Cyclin A
R-HSA-69231: Cyclin D associated events in G1
R-HSA-69202: Cyclin E associated events during G1/S transition
R-HSA-69236: G1 Phase
R-HSA-69206: G1/S Transition
R-HSA-453279: Mitotic G1-G1/S phases
R-HSA-69242: S Phase
R-HSA-187577: SCF(Skp2)-mediated degradation of p27/p21
Summary
SymbolCKS1B
NameCDC28 protein kinase regulatory subunit 1B
Aliases ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CKS1B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CKS1B and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
25597412Non-Small Cell Lung CarcinomaInhibit immunity (T cell function)Our discoveries suggest that the miR-197/CKS1B/STAT3-mediated network can drive tumor PD-L1 expression as a biomarker of this cascade, and miR-197 replacement therapy may be a potential treatment strategy for chemoresistant NSCLC.
Summary
SymbolCKS1B
NameCDC28 protein kinase regulatory subunit 1B
Aliases ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CKS1B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.34; FDR: 0.00722 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCKS1B
NameCDC28 protein kinase regulatory subunit 1B
Aliases ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CKS1B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.4280.127
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.4790.871
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3990.862
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2610.445
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5410.585
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0950.939
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0620.88
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4170.795
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.6360.713
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.5510.786
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.5310.864
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.460.00177
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CKS1B in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCKS1B
NameCDC28 protein kinase regulatory subunit 1B
Aliases ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CKS1B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCKS1B
NameCDC28 protein kinase regulatory subunit 1B
Aliases ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CKS1B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CKS1B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCKS1B
NameCDC28 protein kinase regulatory subunit 1B
Aliases ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CKS1B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCKS1B
NameCDC28 protein kinase regulatory subunit 1B
Aliases ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CKS1B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCKS1B
NameCDC28 protein kinase regulatory subunit 1B
Aliases ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CKS1B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCKS1B
NameCDC28 protein kinase regulatory subunit 1B
Aliases ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CKS1B collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CKS1B.
ID Name Drug Type Targets #Targets
DB00472FluoxetineSmall MoleculeCKS1B, HTR2C, KCNH2, SLC6A44
DB02681Meta VanadateSmall MoleculeCKS1B1