Summary | |
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Symbol | CKS1B |
Name | CDC28 protein kinase regulatory subunit 1B |
Aliases | ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF01111 Cyclin-dependent kinase regulatory subunit |
Function |
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. |
Biological Process |
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0007346 regulation of mitotic cell cycle GO:0033674 positive regulation of kinase activity GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045787 positive regulation of cell cycle GO:0045860 positive regulation of protein kinase activity GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:1904029 regulation of cyclin-dependent protein kinase activity GO:1904031 positive regulation of cyclin-dependent protein kinase activity |
Molecular Function |
GO:0008047 enzyme activator activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity GO:0019207 kinase regulator activity GO:0019209 kinase activator activity GO:0019887 protein kinase regulator activity GO:0030295 protein kinase activator activity GO:0032182 ubiquitin-like protein binding GO:0042393 histone binding GO:0043130 ubiquitin binding GO:0043539 protein serine/threonine kinase activator activity GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity |
Cellular Component |
GO:0000151 ubiquitin ligase complex GO:0000307 cyclin-dependent protein kinase holoenzyme complex GO:0019005 SCF ubiquitin ligase complex GO:0031461 cullin-RING ubiquitin ligase complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:1902554 serine/threonine protein kinase complex GO:1902911 protein kinase complex |
KEGG | - |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-69656: Cyclin A R-HSA-69231: Cyclin D associated events in G1 R-HSA-69202: Cyclin E associated events during G1/S transition R-HSA-69236: G1 Phase R-HSA-69206: G1/S Transition R-HSA-453279: Mitotic G1-G1/S phases R-HSA-69242: S Phase R-HSA-187577: SCF(Skp2)-mediated degradation of p27/p21 |
Summary | |
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Symbol | CKS1B |
Name | CDC28 protein kinase regulatory subunit 1B |
Aliases | ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CKS1B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CKS1B and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CKS1B |
Name | CDC28 protein kinase regulatory subunit 1B |
Aliases | ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CKS1B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CKS1B |
Name | CDC28 protein kinase regulatory subunit 1B |
Aliases | ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CKS1B in various data sets.
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Points in the above scatter plot represent the mutation difference of CKS1B in various data sets.
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Summary | |
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Symbol | CKS1B |
Name | CDC28 protein kinase regulatory subunit 1B |
Aliases | ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CKS1B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CKS1B |
Name | CDC28 protein kinase regulatory subunit 1B |
Aliases | ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CKS1B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CKS1B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CKS1B |
Name | CDC28 protein kinase regulatory subunit 1B |
Aliases | ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CKS1B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CKS1B |
Name | CDC28 protein kinase regulatory subunit 1B |
Aliases | ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CKS1B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CKS1B |
Name | CDC28 protein kinase regulatory subunit 1B |
Aliases | ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CKS1B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CKS1B |
Name | CDC28 protein kinase regulatory subunit 1B |
Aliases | ckshs1; CDC28 protein kinase 1B; PNAS-16; PNAS-18; CDC2-associated protein CKS1; CKS-1; PNAS-143; cell divis ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CKS1B collected from DrugBank database. |
Details on drugs targeting CKS1B.
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