Summary | |
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Symbol | CLDN10 |
Name | claudin 10 |
Aliases | OSP-L; CPETRL3; OSP-like protein; Claudin-10 |
Chromosomal Location | 13q31-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell junction, tight junction Cell membrane Multi-pass membrane protein |
Domain |
PF00822 PMP-22/EMP/MP20/Claudin family |
Function |
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function (PubMed:19383724, PubMed:28771254, PubMed:28686597). |
Biological Process |
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules |
Molecular Function | - |
Cellular Component |
GO:0005923 bicellular tight junction GO:0043296 apical junction complex GO:0070160 occluding junction |
KEGG |
hsa04514 Cell adhesion molecules (CAMs) hsa04530 Tight junction hsa04670 Leukocyte transendothelial migration |
Reactome |
R-HSA-446728: Cell junction organization R-HSA-1500931: Cell-Cell communication R-HSA-421270: Cell-cell junction organization R-HSA-420029: Tight junction interactions |
Summary | |
---|---|
Symbol | CLDN10 |
Name | claudin 10 |
Aliases | OSP-L; CPETRL3; OSP-like protein; Claudin-10 |
Chromosomal Location | 13q31-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CLDN10 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CLDN10 |
Name | claudin 10 |
Aliases | OSP-L; CPETRL3; OSP-like protein; Claudin-10 |
Chromosomal Location | 13q31-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CLDN10 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | CLDN10 |
Name | claudin 10 |
Aliases | OSP-L; CPETRL3; OSP-like protein; Claudin-10 |
Chromosomal Location | 13q31-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CLDN10 in various data sets.
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Points in the above scatter plot represent the mutation difference of CLDN10 in various data sets.
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Summary | |
---|---|
Symbol | CLDN10 |
Name | claudin 10 |
Aliases | OSP-L; CPETRL3; OSP-like protein; Claudin-10 |
Chromosomal Location | 13q31-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CLDN10. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CLDN10 |
Name | claudin 10 |
Aliases | OSP-L; CPETRL3; OSP-like protein; Claudin-10 |
Chromosomal Location | 13q31-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CLDN10. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CLDN10. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CLDN10 |
Name | claudin 10 |
Aliases | OSP-L; CPETRL3; OSP-like protein; Claudin-10 |
Chromosomal Location | 13q31-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CLDN10. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CLDN10 |
Name | claudin 10 |
Aliases | OSP-L; CPETRL3; OSP-like protein; Claudin-10 |
Chromosomal Location | 13q31-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CLDN10 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CLDN10 |
Name | claudin 10 |
Aliases | OSP-L; CPETRL3; OSP-like protein; Claudin-10 |
Chromosomal Location | 13q31-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CLDN10 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |