Summary | |
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Symbol | CLEC4G |
Name | C-type lectin domain family 4, member G |
Aliases | UNQ431; LSECtin; C-type lectin superfamily 4, member G; DTTR431; LP2698; liver and lymph node sinusoidal end ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type II membrane protein |
Domain |
PF00059 Lectin C-type domain |
Function |
Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro. ; FUNCTION: (Microbial infection) Acts as a receptor for Japanese encephalitis virus. ; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus. ; FUNCTION: (Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV. ; FUNCTION: (Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088). |
Biological Process |
GO:0002250 adaptive immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002704 negative regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002707 negative regulation of lymphocyte mediated immunity GO:0002709 regulation of T cell mediated immunity GO:0002710 negative regulation of T cell mediated immunity GO:0002819 regulation of adaptive immune response GO:0002820 negative regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0019058 viral life cycle GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0030260 entry into host cell GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032945 negative regulation of mononuclear cell proliferation GO:0042098 T cell proliferation GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042130 negative regulation of T cell proliferation GO:0044409 entry into host GO:0046651 lymphocyte proliferation GO:0046718 viral entry into host cell GO:0050670 regulation of lymphocyte proliferation GO:0050672 negative regulation of lymphocyte proliferation GO:0050777 negative regulation of immune response GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051701 interaction with host GO:0051806 entry into cell of other organism involved in symbiotic interaction GO:0051828 entry into other organism involved in symbiotic interaction GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070664 negative regulation of leukocyte proliferation GO:0071593 lymphocyte aggregation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion |
Molecular Function |
GO:0001618 virus receptor activity GO:0001871 pattern binding GO:0030246 carbohydrate binding GO:0030247 polysaccharide binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | CLEC4G |
Name | C-type lectin domain family 4, member G |
Aliases | UNQ431; LSECtin; C-type lectin superfamily 4, member G; DTTR431; LP2698; liver and lymph node sinusoidal end ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CLEC4G and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CLEC4G and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CLEC4G |
Name | C-type lectin domain family 4, member G |
Aliases | UNQ431; LSECtin; C-type lectin superfamily 4, member G; DTTR431; LP2698; liver and lymph node sinusoidal end ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CLEC4G in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CLEC4G |
Name | C-type lectin domain family 4, member G |
Aliases | UNQ431; LSECtin; C-type lectin superfamily 4, member G; DTTR431; LP2698; liver and lymph node sinusoidal end ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CLEC4G in various data sets.
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Points in the above scatter plot represent the mutation difference of CLEC4G in various data sets.
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Summary | |
---|---|
Symbol | CLEC4G |
Name | C-type lectin domain family 4, member G |
Aliases | UNQ431; LSECtin; C-type lectin superfamily 4, member G; DTTR431; LP2698; liver and lymph node sinusoidal end ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CLEC4G. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CLEC4G |
Name | C-type lectin domain family 4, member G |
Aliases | UNQ431; LSECtin; C-type lectin superfamily 4, member G; DTTR431; LP2698; liver and lymph node sinusoidal end ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CLEC4G. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CLEC4G. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CLEC4G |
Name | C-type lectin domain family 4, member G |
Aliases | UNQ431; LSECtin; C-type lectin superfamily 4, member G; DTTR431; LP2698; liver and lymph node sinusoidal end ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CLEC4G. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CLEC4G |
Name | C-type lectin domain family 4, member G |
Aliases | UNQ431; LSECtin; C-type lectin superfamily 4, member G; DTTR431; LP2698; liver and lymph node sinusoidal end ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CLEC4G expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CLEC4G |
Name | C-type lectin domain family 4, member G |
Aliases | UNQ431; LSECtin; C-type lectin superfamily 4, member G; DTTR431; LP2698; liver and lymph node sinusoidal end ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CLEC4G and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CLEC4G |
Name | C-type lectin domain family 4, member G |
Aliases | UNQ431; LSECtin; C-type lectin superfamily 4, member G; DTTR431; LP2698; liver and lymph node sinusoidal end ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CLEC4G collected from DrugBank database. |
There is no record. |