Summary | |
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Symbol | CLEC4M |
Name | C-type lectin domain family 4, member M |
Aliases | HP10347; DC-SIGNR; LSIGN; DCSIGNR; DC-SIGN2; CD209L; CD299; CD299 antigen; L-SIGN; CD209 antigen-like protei ...... |
Chromosomal Location | 19p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cell membrane Single-pass type II membrane protein ; SUBCELLULAR LOCATION: Isoform 2: Cell membrane Single-pass type II membrane protein ; SUBCELLULAR LOCATION: Isoform 3: Cell membrane Single-pass type II membrane protein ; SUBCELLULAR LOCATION: Isoform 5: Secreted ; SUBCELLULAR LOCATION: Isoform 6: Secreted ; SUBCELLULAR LOCATION: Isoform 7: Secreted ; SUBCELLULAR LOCATION: Isoform 10: Secreted |
Domain |
PF00059 Lectin C-type domain |
Function |
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Ebolavirus. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Hepatitis C virus. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for HIV-1. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Influenzavirus. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for SARS coronavirus. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for West-nile virus. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. ; FUNCTION: (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein. ; FUNCTION: (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule. |
Biological Process |
GO:0002250 adaptive immune response GO:0007159 leukocyte cell-cell adhesion GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008037 cell recognition GO:0009988 cell-cell recognition GO:0015833 peptide transport GO:0019048 modulation by virus of host morphology or physiology GO:0019058 viral life cycle GO:0019062 virion attachment to host cell GO:0019079 viral genome replication GO:0019882 antigen processing and presentation GO:0030193 regulation of blood coagulation GO:0030260 entry into host cell GO:0035821 modification of morphology or physiology of other organism GO:0042886 amide transport GO:0044003 modification by symbiont of host morphology or physiology GO:0044406 adhesion of symbiont to host GO:0044409 entry into host GO:0044650 adhesion of symbiont to host cell GO:0044766 multi-organism transport GO:0046718 viral entry into host cell GO:0046794 transport of virus GO:0046968 peptide antigen transport GO:0048002 antigen processing and presentation of peptide antigen GO:0050817 coagulation GO:0050818 regulation of coagulation GO:0050878 regulation of body fluid levels GO:0051701 interaction with host GO:0051806 entry into cell of other organism involved in symbiotic interaction GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051828 entry into other organism involved in symbiotic interaction GO:0061041 regulation of wound healing GO:0075733 intracellular transport of virus GO:1900046 regulation of hemostasis GO:1902579 multi-organism localization GO:1902581 multi-organism cellular localization GO:1902583 multi-organism intracellular transport GO:1903034 regulation of response to wounding |
Molecular Function |
GO:0001618 virus receptor activity GO:0003823 antigen binding GO:0005537 mannose binding GO:0030246 carbohydrate binding GO:0030369 ICAM-3 receptor activity GO:0033218 amide binding GO:0042277 peptide binding GO:0042605 peptide antigen binding GO:0046790 virion binding GO:0048029 monosaccharide binding GO:0048306 calcium-dependent protein binding |
Cellular Component | - |
KEGG |
hsa04145 Phagosome |
Reactome | - |
Summary | |
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Symbol | CLEC4M |
Name | C-type lectin domain family 4, member M |
Aliases | HP10347; DC-SIGNR; LSIGN; DCSIGNR; DC-SIGN2; CD209L; CD299; CD299 antigen; L-SIGN; CD209 antigen-like protei ...... |
Chromosomal Location | 19p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CLEC4M and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CLEC4M |
Name | C-type lectin domain family 4, member M |
Aliases | HP10347; DC-SIGNR; LSIGN; DCSIGNR; DC-SIGN2; CD209L; CD299; CD299 antigen; L-SIGN; CD209 antigen-like protei ...... |
Chromosomal Location | 19p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CLEC4M in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CLEC4M |
Name | C-type lectin domain family 4, member M |
Aliases | HP10347; DC-SIGNR; LSIGN; DCSIGNR; DC-SIGN2; CD209L; CD299; CD299 antigen; L-SIGN; CD209 antigen-like protei ...... |
Chromosomal Location | 19p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CLEC4M in various data sets.
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Points in the above scatter plot represent the mutation difference of CLEC4M in various data sets.
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Summary | |
---|---|
Symbol | CLEC4M |
Name | C-type lectin domain family 4, member M |
Aliases | HP10347; DC-SIGNR; LSIGN; DCSIGNR; DC-SIGN2; CD209L; CD299; CD299 antigen; L-SIGN; CD209 antigen-like protei ...... |
Chromosomal Location | 19p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CLEC4M. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CLEC4M |
Name | C-type lectin domain family 4, member M |
Aliases | HP10347; DC-SIGNR; LSIGN; DCSIGNR; DC-SIGN2; CD209L; CD299; CD299 antigen; L-SIGN; CD209 antigen-like protei ...... |
Chromosomal Location | 19p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CLEC4M. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CLEC4M. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CLEC4M |
Name | C-type lectin domain family 4, member M |
Aliases | HP10347; DC-SIGNR; LSIGN; DCSIGNR; DC-SIGN2; CD209L; CD299; CD299 antigen; L-SIGN; CD209 antigen-like protei ...... |
Chromosomal Location | 19p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CLEC4M. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CLEC4M |
Name | C-type lectin domain family 4, member M |
Aliases | HP10347; DC-SIGNR; LSIGN; DCSIGNR; DC-SIGN2; CD209L; CD299; CD299 antigen; L-SIGN; CD209 antigen-like protei ...... |
Chromosomal Location | 19p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CLEC4M expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CLEC4M |
Name | C-type lectin domain family 4, member M |
Aliases | HP10347; DC-SIGNR; LSIGN; DCSIGNR; DC-SIGN2; CD209L; CD299; CD299 antigen; L-SIGN; CD209 antigen-like protei ...... |
Chromosomal Location | 19p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CLEC4M and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CLEC4M |
Name | C-type lectin domain family 4, member M |
Aliases | HP10347; DC-SIGNR; LSIGN; DCSIGNR; DC-SIGN2; CD209L; CD299; CD299 antigen; L-SIGN; CD209 antigen-like protei ...... |
Chromosomal Location | 19p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CLEC4M collected from DrugBank database. |
There is no record. |