TISIDB

Summary
Symbol	CLIC5
Name	chloride intracellular channel 5
Aliases	DFNB103; MST130; MSTP130; Chloride intracellular channel protein 5
Chromosomal Location	6p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Isoform 1: Cytoplasm, cell cortex Cytoplasm, cytoskeleton Membrane Single-pass membrane protein Note=Associates with the cortical actin cytoskeleton. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). ; SUBCELLULAR LOCATION: Isoform 2: Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Single-pass membrane protein. Note=Colocalized with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). Colocalized with podocalyxin in renal glomeruli.
Domain	PF13417 Glutathione S-transferase
Function	Required for normal hearing (PubMed:24781754). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:15184393, PubMed:18028448, PubMed:20335315).

> Gene Ontology [ TOP ]
Biological Process	GO:0002021 response to dietary excess GO:0002024 diet induced thermogenesis GO:0002064 epithelial cell development GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0002066 columnar/cuboidal epithelial cell development GO:0002093 auditory receptor cell morphogenesis GO:0006820 anion transport GO:0006821 chloride transport GO:0007423 sensory organ development GO:0007565 female pregnancy GO:0007605 sensory perception of sound GO:0008544 epidermis development GO:0009913 epidermal cell differentiation GO:0009991 response to extracellular stimulus GO:0015698 inorganic anion transport GO:0031667 response to nutrient levels GO:0034762 regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0035315 hair cell differentiation GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0042490 mechanoreceptor differentiation GO:0042491 auditory receptor cell differentiation GO:0043583 ear development GO:0044236 multicellular organism metabolic process GO:0044706 multi-multicellular organism process GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048839 inner ear development GO:0050885 neuromuscular process controlling balance GO:0050905 neuromuscular process GO:0050954 sensory perception of mechanical stimulus GO:0060088 auditory receptor cell stereocilium organization GO:0060113 inner ear receptor cell differentiation GO:0060117 auditory receptor cell development GO:0060119 inner ear receptor cell development GO:0060122 inner ear receptor stereocilium organization GO:0060563 neuroepithelial cell differentiation GO:0090596 sensory organ morphogenesis GO:0098656 anion transmembrane transport GO:0098661 inorganic anion transmembrane transport GO:1902476 chloride transmembrane transport GO:1990845 adaptive thermogenesis
Molecular Function	GO:0005216 ion channel activity GO:0005244 voltage-gated ion channel activity GO:0005253 anion channel activity GO:0005254 chloride channel activity GO:0008509 anion transmembrane transporter activity GO:0015103 inorganic anion transmembrane transporter activity GO:0015108 chloride transmembrane transporter activity GO:0015267 channel activity GO:0022803 passive transmembrane transporter activity GO:0022832 voltage-gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity
Cellular Component	GO:0005938 cell cortex GO:0015629 actin cytoskeleton GO:0032420 stereocilium GO:0032421 stereocilium bundle GO:0034702 ion channel complex GO:0034707 chloride channel complex GO:0098858 actin-based cell projection GO:0098862 cluster of actin-based cell projections GO:0099568 cytoplasmic region GO:1902495 transmembrane transporter complex GO:1990351 transporter complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	CLIC5
Name	chloride intracellular channel 5
Aliases	DFNB103; MST130; MSTP130; Chloride intracellular channel protein 5
Chromosomal Location	6p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between CLIC5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	CLIC5
Name	chloride intracellular channel 5
Aliases	DFNB103; MST130; MSTP130; Chloride intracellular channel protein 5
Chromosomal Location	6p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of CLIC5 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	CLIC5
Name	chloride intracellular channel 5
Aliases	DFNB103; MST130; MSTP130; Chloride intracellular channel protein 5
Chromosomal Location	6p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of CLIC5 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.506	0.0574
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.776	0.106
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.304	0.448
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.968	0.0491
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.838	0.559
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	1.132	0.512
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0	1
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.502	0.593
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.543	0.588
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.082	0.891
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.964	0.203
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.022	0.927

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of CLIC5 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	4.1	3.3	0.61
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	7.1	-7.1	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	3.4	4	0.587
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	9.5	0	9.5	0.492
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	CLIC5
Name	chloride intracellular channel 5
Aliases	DFNB103; MST130; MSTP130; Chloride intracellular channel protein 5
Chromosomal Location	6p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CLIC5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	CLIC5
Name	chloride intracellular channel 5
Aliases	DFNB103; MST130; MSTP130; Chloride intracellular channel protein 5
Chromosomal Location	6p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CLIC5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CLIC5. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	CLIC5
Name	chloride intracellular channel 5
Aliases	DFNB103; MST130; MSTP130; Chloride intracellular channel protein 5
Chromosomal Location	6p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CLIC5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	CLIC5
Name	chloride intracellular channel 5
Aliases	DFNB103; MST130; MSTP130; Chloride intracellular channel protein 5
Chromosomal Location	6p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of CLIC5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	CLIC5
Name	chloride intracellular channel 5
Aliases	DFNB103; MST130; MSTP130; Chloride intracellular channel protein 5
Chromosomal Location	6p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between CLIC5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	CLIC5
Name	chloride intracellular channel 5
Aliases	DFNB103; MST130; MSTP130; Chloride intracellular channel protein 5
Chromosomal Location	6p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting CLIC5 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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