Browse CLSTN2

Summary
SymbolCLSTN2
Namecalsyntenin 2
Aliases CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass type I membrane protein Endoplasmic reticulum membrane. Golgi apparatus membrane. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization.
Domain PF00028 Cadherin domain
Function

May modulate calcium-mediated postsynaptic signals.

> Gene Ontology
 
Biological Process GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007416 synapse assembly
GO:0044089 positive regulation of cellular component biogenesis
GO:0050803 regulation of synapse structure or activity
GO:0050804 modulation of synaptic transmission
GO:0050806 positive regulation of synaptic transmission
GO:0050807 regulation of synapse organization
GO:0050808 synapse organization
GO:0051962 positive regulation of nervous system development
GO:0051963 regulation of synapse assembly
GO:0051965 positive regulation of synapse assembly
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
Molecular Function -
Cellular Component GO:0045211 postsynaptic membrane
GO:0097060 synaptic membrane
GO:0098794 postsynapse
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolCLSTN2
Namecalsyntenin 2
Aliases CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CLSTN2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCLSTN2
Namecalsyntenin 2
Aliases CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CLSTN2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCLSTN2
Namecalsyntenin 2
Aliases CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CLSTN2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1790.413
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1570.734
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4240.258
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0180.967
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0250.986
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0150.994
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0990.891
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.6590.528
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.7250.502
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4370.533
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0340.258
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2280.317
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CLSTN2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141728.6028.60.0318
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103400400.497
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.12.78.40.12
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.13.47.70.176
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211723.85.917.90.197
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131130.89.121.70.327
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382713.23.79.50.388
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.2018.20.274
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCLSTN2
Namecalsyntenin 2
Aliases CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CLSTN2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCLSTN2
Namecalsyntenin 2
Aliases CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CLSTN2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CLSTN2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCLSTN2
Namecalsyntenin 2
Aliases CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CLSTN2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCLSTN2
Namecalsyntenin 2
Aliases CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CLSTN2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCLSTN2
Namecalsyntenin 2
Aliases CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CLSTN2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCLSTN2
Namecalsyntenin 2
Aliases CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CLSTN2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.