Summary | |
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Symbol | CLSTN2 |
Name | calsyntenin 2 |
Aliases | CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Endoplasmic reticulum membrane. Golgi apparatus membrane. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. |
Domain |
PF00028 Cadherin domain |
Function |
May modulate calcium-mediated postsynaptic signals. |
Biological Process |
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007416 synapse assembly GO:0044089 positive regulation of cellular component biogenesis GO:0050803 regulation of synapse structure or activity GO:0050804 modulation of synaptic transmission GO:0050806 positive regulation of synaptic transmission GO:0050807 regulation of synapse organization GO:0050808 synapse organization GO:0051962 positive regulation of nervous system development GO:0051963 regulation of synapse assembly GO:0051965 positive regulation of synapse assembly GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules |
Molecular Function | - |
Cellular Component |
GO:0045211 postsynaptic membrane GO:0097060 synaptic membrane GO:0098794 postsynapse |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | CLSTN2 |
Name | calsyntenin 2 |
Aliases | CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CLSTN2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CLSTN2 |
Name | calsyntenin 2 |
Aliases | CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CLSTN2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CLSTN2 |
Name | calsyntenin 2 |
Aliases | CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CLSTN2 in various data sets.
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Points in the above scatter plot represent the mutation difference of CLSTN2 in various data sets.
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Summary | |
---|---|
Symbol | CLSTN2 |
Name | calsyntenin 2 |
Aliases | CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CLSTN2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CLSTN2 |
Name | calsyntenin 2 |
Aliases | CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CLSTN2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CLSTN2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CLSTN2 |
Name | calsyntenin 2 |
Aliases | CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CLSTN2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CLSTN2 |
Name | calsyntenin 2 |
Aliases | CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CLSTN2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CLSTN2 |
Name | calsyntenin 2 |
Aliases | CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CLSTN2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CLSTN2 |
Name | calsyntenin 2 |
Aliases | CSTN2; CS2; FLJ39113; CDHR13; cadherin-related family member 13; ALC-GAMMA; alcagamma; alcadein gamma; alcad ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CLSTN2 collected from DrugBank database. |
There is no record. |