Summary | |
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Symbol | CLU |
Name | clusterin |
Aliases | SGP-2; SP-40; TRPM-2; KUB1; CLU2; complement lysis inhibitor; sulfated glycoprotein 2; testosterone-represse ...... |
Chromosomal Location | 8p21-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Secreted. Note=Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress.; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Cytoplasmic vesicle, secretory vesicle, chromaffin granule Note=Isoforms lacking the N-terminal signal sequence have been shown to be cytoplasmic and/or nuclear. Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Detected at the mitochondrion membrane upon induction of apoptosis. |
Domain |
PF01093 Clusterin |
Function |
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation. |
Biological Process |
GO:0001774 microglial cell activation GO:0001819 positive regulation of cytokine production GO:0001836 release of cytochrome c from mitochondria GO:0002250 adaptive immune response GO:0002274 myeloid leukocyte activation GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002455 humoral immune response mediated by circulating immunoglobulin GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002576 platelet degranulation GO:0006457 protein folding GO:0006809 nitric oxide biosynthetic process GO:0006869 lipid transport GO:0006887 exocytosis GO:0006956 complement activation GO:0006958 complement activation, classical pathway GO:0006959 humoral immune response GO:0007009 plasma membrane organization GO:0007272 ensheathment of neurons GO:0008366 axon ensheathment GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008637 apoptotic mitochondrial changes GO:0009615 response to virus GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0010001 glial cell differentiation GO:0010498 proteasomal protein catabolic process GO:0010876 lipid localization GO:0014003 oligodendrocyte development GO:0014009 glial cell proliferation GO:0015850 organic hydroxy compound transport GO:0015918 sterol transport GO:0016064 immunoglobulin mediated immune response GO:0017038 protein import GO:0019724 B cell mediated immunity GO:0021782 glial cell development GO:0022010 central nervous system myelination GO:0023041 neuronal signal transduction GO:0030301 cholesterol transport GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031333 negative regulation of protein complex assembly GO:0031396 regulation of protein ubiquitination GO:0031398 positive regulation of protein ubiquitination GO:0031647 regulation of protein stability GO:0032286 central nervous system myelin maintenance GO:0032291 axon ensheathment in central nervous system GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032459 regulation of protein oligomerization GO:0032460 negative regulation of protein oligomerization GO:0032462 regulation of protein homooligomerization GO:0032463 negative regulation of protein homooligomerization GO:0032640 tumor necrosis factor production GO:0032680 regulation of tumor necrosis factor production GO:0032760 positive regulation of tumor necrosis factor production GO:0033674 positive regulation of kinase activity GO:0034205 beta-amyloid formation GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0034250 positive regulation of cellular amide metabolic process GO:0035966 response to topologically incorrect protein GO:0042063 gliogenesis GO:0042116 macrophage activation GO:0042176 regulation of protein catabolic process GO:0042552 myelination GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042982 amyloid precursor protein metabolic process GO:0042987 amyloid precursor protein catabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043217 myelin maintenance GO:0043254 regulation of protein complex assembly GO:0043691 reverse cholesterol transport GO:0044089 positive regulation of cellular component biogenesis GO:0045055 regulated exocytosis GO:0045428 regulation of nitric oxide biosynthetic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045732 positive regulation of protein catabolic process GO:0045860 positive regulation of protein kinase activity GO:0045862 positive regulation of proteolysis GO:0046209 nitric oxide metabolic process GO:0048709 oligodendrocyte differentiation GO:0050435 beta-amyloid metabolic process GO:0050821 protein stabilization GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051131 chaperone-mediated protein complex assembly GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051788 response to misfolded protein GO:0061077 chaperone-mediated protein folding GO:0061136 regulation of proteasomal protein catabolic process GO:0061517 macrophage proliferation GO:0061518 microglial cell proliferation GO:0070661 leukocyte proliferation GO:0070841 inclusion body assembly GO:0070997 neuron death GO:0071706 tumor necrosis factor superfamily cytokine production GO:0072376 protein activation cascade GO:0072593 reactive oxygen species metabolic process GO:0090083 regulation of inclusion body assembly GO:0090261 positive regulation of inclusion body assembly GO:0097193 intrinsic apoptotic signaling pathway GO:0097242 beta-amyloid clearance GO:1900221 regulation of beta-amyloid clearance GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1901800 positive regulation of proteasomal protein catabolic process GO:1902003 regulation of beta-amyloid formation GO:1902004 positive regulation of beta-amyloid formation GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902430 negative regulation of beta-amyloid formation GO:1902532 negative regulation of intracellular signal transduction GO:1902847 regulation of neuronal signal transduction GO:1902947 regulation of tau-protein kinase activity GO:1902949 positive regulation of tau-protein kinase activity GO:1902988 neurofibrillary tangle assembly GO:1902991 regulation of amyloid precursor protein catabolic process GO:1902992 negative regulation of amyloid precursor protein catabolic process GO:1902993 positive regulation of amyloid precursor protein catabolic process GO:1902996 regulation of neurofibrillary tangle assembly GO:1902998 positive regulation of neurofibrillary tangle assembly GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903322 positive regulation of protein modification by small protein conjugation or removal GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:1904407 positive regulation of nitric oxide metabolic process GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus GO:2001057 reactive nitrogen species metabolic process GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0031625 ubiquitin protein ligase binding GO:0044389 ubiquitin-like protein ligase binding GO:0051087 chaperone binding GO:0051787 misfolded protein binding |
Cellular Component |
GO:0016234 inclusion body GO:0030141 secretory granule GO:0030425 dendrite GO:0031091 platelet alpha granule GO:0031093 platelet alpha granule lumen GO:0031983 vesicle lumen GO:0032994 protein-lipid complex GO:0034358 plasma lipoprotein particle GO:0034364 high-density lipoprotein particle GO:0034366 spherical high-density lipoprotein particle GO:0034774 secretory granule lumen GO:0042583 chromaffin granule GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0072562 blood microparticle GO:0097418 neurofibrillary tangle GO:0097440 apical dendrite GO:0099503 secretory vesicle GO:1990777 lipoprotein particle |
KEGG |
hsa04610 Complement and coagulation cascades |
Reactome |
R-HSA-6803157: Antimicrobial peptides R-HSA-166658: Complement cascade R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-114608: Platelet degranulation R-HSA-76005: Response to elevated platelet cytosolic Ca2+ R-HSA-166665: Terminal pathway of complement |
Summary | |
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Symbol | CLU |
Name | clusterin |
Aliases | SGP-2; SP-40; TRPM-2; KUB1; CLU2; complement lysis inhibitor; sulfated glycoprotein 2; testosterone-represse ...... |
Chromosomal Location | 8p21-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CLU and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | CLU |
Name | clusterin |
Aliases | SGP-2; SP-40; TRPM-2; KUB1; CLU2; complement lysis inhibitor; sulfated glycoprotein 2; testosterone-represse ...... |
Chromosomal Location | 8p21-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CLU in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CLU |
Name | clusterin |
Aliases | SGP-2; SP-40; TRPM-2; KUB1; CLU2; complement lysis inhibitor; sulfated glycoprotein 2; testosterone-represse ...... |
Chromosomal Location | 8p21-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CLU in various data sets.
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Points in the above scatter plot represent the mutation difference of CLU in various data sets.
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Summary | |
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Symbol | CLU |
Name | clusterin |
Aliases | SGP-2; SP-40; TRPM-2; KUB1; CLU2; complement lysis inhibitor; sulfated glycoprotein 2; testosterone-represse ...... |
Chromosomal Location | 8p21-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CLU. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CLU |
Name | clusterin |
Aliases | SGP-2; SP-40; TRPM-2; KUB1; CLU2; complement lysis inhibitor; sulfated glycoprotein 2; testosterone-represse ...... |
Chromosomal Location | 8p21-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CLU. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CLU. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CLU |
Name | clusterin |
Aliases | SGP-2; SP-40; TRPM-2; KUB1; CLU2; complement lysis inhibitor; sulfated glycoprotein 2; testosterone-represse ...... |
Chromosomal Location | 8p21-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CLU. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CLU |
Name | clusterin |
Aliases | SGP-2; SP-40; TRPM-2; KUB1; CLU2; complement lysis inhibitor; sulfated glycoprotein 2; testosterone-represse ...... |
Chromosomal Location | 8p21-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CLU expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CLU |
Name | clusterin |
Aliases | SGP-2; SP-40; TRPM-2; KUB1; CLU2; complement lysis inhibitor; sulfated glycoprotein 2; testosterone-represse ...... |
Chromosomal Location | 8p21-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CLU and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CLU |
Name | clusterin |
Aliases | SGP-2; SP-40; TRPM-2; KUB1; CLU2; complement lysis inhibitor; sulfated glycoprotein 2; testosterone-represse ...... |
Chromosomal Location | 8p21-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CLU collected from DrugBank database. |
Details on drugs targeting CLU.
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