Browse CLYBL

Summary
SymbolCLYBL
Namecitrate lyase beta like
Aliases CLB; beta-methylmalate synthase; malate synthase; Citrate lyase beta-like; Citrate lyase subunit beta-like p ......
Chromosomal Location13q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion
Domain PF03328 HpcH/HpaI aldolase/citrate lyase family
Function

Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341). Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (PubMed:24334609, PubMed:29056341). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (PubMed:24334609, PubMed:29056341). Also has very weak citramalate synthase activity in vitro (PubMed:24334609, PubMed:29056341).

> Gene Ontology
 
Biological Process -
Molecular Function GO:0000287 magnesium ion binding
GO:0004474 malate synthase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolCLYBL
Namecitrate lyase beta like
Aliases CLB; beta-methylmalate synthase; malate synthase; Citrate lyase beta-like; Citrate lyase subunit beta-like p ......
Chromosomal Location13q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CLYBL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCLYBL
Namecitrate lyase beta like
Aliases CLB; beta-methylmalate synthase; malate synthase; Citrate lyase beta-like; Citrate lyase subunit beta-like p ......
Chromosomal Location13q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CLYBL in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCLYBL
Namecitrate lyase beta like
Aliases CLB; beta-methylmalate synthase; malate synthase; Citrate lyase beta-like; Citrate lyase subunit beta-like p ......
Chromosomal Location13q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CLYBL in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.9080.0492
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.7780.556
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.0020.328
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2740.448
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0850.935
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.5160.672
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1710.554
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0630.942
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3490.735
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.8920.534
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.6880.74
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1180.307
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CLYBL in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCLYBL
Namecitrate lyase beta like
Aliases CLB; beta-methylmalate synthase; malate synthase; Citrate lyase beta-like; Citrate lyase subunit beta-like p ......
Chromosomal Location13q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CLYBL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCLYBL
Namecitrate lyase beta like
Aliases CLB; beta-methylmalate synthase; malate synthase; Citrate lyase beta-like; Citrate lyase subunit beta-like p ......
Chromosomal Location13q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CLYBL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CLYBL.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCLYBL
Namecitrate lyase beta like
Aliases CLB; beta-methylmalate synthase; malate synthase; Citrate lyase beta-like; Citrate lyase subunit beta-like p ......
Chromosomal Location13q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CLYBL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCLYBL
Namecitrate lyase beta like
Aliases CLB; beta-methylmalate synthase; malate synthase; Citrate lyase beta-like; Citrate lyase subunit beta-like p ......
Chromosomal Location13q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CLYBL expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCLYBL
Namecitrate lyase beta like
Aliases CLB; beta-methylmalate synthase; malate synthase; Citrate lyase beta-like; Citrate lyase subunit beta-like p ......
Chromosomal Location13q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CLYBL and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCLYBL
Namecitrate lyase beta like
Aliases CLB; beta-methylmalate synthase; malate synthase; Citrate lyase beta-like; Citrate lyase subunit beta-like p ......
Chromosomal Location13q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CLYBL collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.