Summary | |
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Symbol | CMPK2 |
Name | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
Aliases | TYKi; UMP-CMPK2; cytidylate kinase 2; TMPK2; mitochondrial UMP-CMP kinase; thymidine monophosphate kinase 2; ...... |
Chromosomal Location | 2p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion |
Domain | - |
Function |
May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. |
Biological Process |
GO:0002237 response to molecule of bacterial origin GO:0006165 nucleoside diphosphate phosphorylation GO:0006220 pyrimidine nucleotide metabolic process GO:0006221 pyrimidine nucleotide biosynthetic process GO:0006227 dUDP biosynthetic process GO:0006233 dTDP biosynthetic process GO:0006235 dTTP biosynthetic process GO:0009132 nucleoside diphosphate metabolic process GO:0009133 nucleoside diphosphate biosynthetic process GO:0009138 pyrimidine nucleoside diphosphate metabolic process GO:0009139 pyrimidine nucleoside diphosphate biosynthetic process GO:0009141 nucleoside triphosphate metabolic process GO:0009142 nucleoside triphosphate biosynthetic process GO:0009147 pyrimidine nucleoside triphosphate metabolic process GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009186 deoxyribonucleoside diphosphate metabolic process GO:0009189 deoxyribonucleoside diphosphate biosynthetic process GO:0009196 pyrimidine deoxyribonucleoside diphosphate metabolic process GO:0009197 pyrimidine deoxyribonucleoside diphosphate biosynthetic process GO:0009200 deoxyribonucleoside triphosphate metabolic process GO:0009202 deoxyribonucleoside triphosphate biosynthetic process GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process GO:0009212 pyrimidine deoxyribonucleoside triphosphate biosynthetic process GO:0009219 pyrimidine deoxyribonucleotide metabolic process GO:0009221 pyrimidine deoxyribonucleotide biosynthetic process GO:0009262 deoxyribonucleotide metabolic process GO:0009263 deoxyribonucleotide biosynthetic process GO:0009265 2'-deoxyribonucleotide biosynthetic process GO:0009394 2'-deoxyribonucleotide metabolic process GO:0019692 deoxyribose phosphate metabolic process GO:0032496 response to lipopolysaccharide GO:0046072 dTDP metabolic process GO:0046075 dTTP metabolic process GO:0046077 dUDP metabolic process GO:0046385 deoxyribose phosphate biosynthetic process GO:0046939 nucleotide phosphorylation GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071396 cellular response to lipid GO:0072527 pyrimidine-containing compound metabolic process GO:0072528 pyrimidine-containing compound biosynthetic process GO:1901293 nucleoside phosphate biosynthetic process |
Molecular Function |
GO:0004127 cytidylate kinase activity GO:0004550 nucleoside diphosphate kinase activity GO:0004798 thymidylate kinase activity GO:0009041 uridylate kinase activity GO:0016776 phosphotransferase activity, phosphate group as acceptor GO:0019201 nucleotide kinase activity GO:0019205 nucleobase-containing compound kinase activity GO:0033862 UMP kinase activity |
Cellular Component | - |
KEGG |
hsa00240 Pyrimidine metabolism hsa01100 Metabolic pathways |
Reactome | - |
Summary | |
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Symbol | CMPK2 |
Name | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
Aliases | TYKi; UMP-CMPK2; cytidylate kinase 2; TMPK2; mitochondrial UMP-CMP kinase; thymidine monophosphate kinase 2; ...... |
Chromosomal Location | 2p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CMPK2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CMPK2 |
Name | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
Aliases | TYKi; UMP-CMPK2; cytidylate kinase 2; TMPK2; mitochondrial UMP-CMP kinase; thymidine monophosphate kinase 2; ...... |
Chromosomal Location | 2p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CMPK2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CMPK2 |
Name | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
Aliases | TYKi; UMP-CMPK2; cytidylate kinase 2; TMPK2; mitochondrial UMP-CMP kinase; thymidine monophosphate kinase 2; ...... |
Chromosomal Location | 2p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CMPK2 in various data sets.
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Points in the above scatter plot represent the mutation difference of CMPK2 in various data sets.
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Summary | |
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Symbol | CMPK2 |
Name | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
Aliases | TYKi; UMP-CMPK2; cytidylate kinase 2; TMPK2; mitochondrial UMP-CMP kinase; thymidine monophosphate kinase 2; ...... |
Chromosomal Location | 2p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CMPK2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CMPK2 |
Name | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
Aliases | TYKi; UMP-CMPK2; cytidylate kinase 2; TMPK2; mitochondrial UMP-CMP kinase; thymidine monophosphate kinase 2; ...... |
Chromosomal Location | 2p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CMPK2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CMPK2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CMPK2 |
Name | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
Aliases | TYKi; UMP-CMPK2; cytidylate kinase 2; TMPK2; mitochondrial UMP-CMP kinase; thymidine monophosphate kinase 2; ...... |
Chromosomal Location | 2p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CMPK2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CMPK2 |
Name | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
Aliases | TYKi; UMP-CMPK2; cytidylate kinase 2; TMPK2; mitochondrial UMP-CMP kinase; thymidine monophosphate kinase 2; ...... |
Chromosomal Location | 2p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CMPK2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CMPK2 |
Name | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
Aliases | TYKi; UMP-CMPK2; cytidylate kinase 2; TMPK2; mitochondrial UMP-CMP kinase; thymidine monophosphate kinase 2; ...... |
Chromosomal Location | 2p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CMPK2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CMPK2 |
Name | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
Aliases | TYKi; UMP-CMPK2; cytidylate kinase 2; TMPK2; mitochondrial UMP-CMP kinase; thymidine monophosphate kinase 2; ...... |
Chromosomal Location | 2p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CMPK2 collected from DrugBank database. |
There is no record. |